A5071483631- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- MRI in cancer diagnosis
- Fetal and Pediatric Neurological Disorders
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Hearing Loss and Rehabilitation
- Multisensory perception and integration
- Neuroscience and Music Perception
- Visual perception and processing mechanisms
- Neural dynamics and brain function
- Bone and Joint Diseases
- Phonetics and Phonology Research
- Obsessive-Compulsive Spectrum Disorders
- Neurobiology of Language and Bilingualism
- NMR spectroscopy and applications
- Medical Image Segmentation Techniques
- Optical Coherence Tomography Applications
- Vestibular and auditory disorders
- Neurological disorders and treatments
- Advanced Fluorescence Microscopy Techniques
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Retinal Imaging and Analysis
Center for Neuro-Oncology
2022-2025
Massachusetts General Hospital
2018-2025
Athinoula A. Martinos Center for Biomedical Imaging
2018-2025
Harvard University
2019-2025
McLean Hospital
2024
Cardiff University
2021
Harvard University Press
2021
Walter Reed National Military Medical Center
2021
Murdoch Children's Research Institute
2021
Boston University
2019
Consciousness is composed of arousal (i.e., wakefulness) and awareness. Substantial progress has been made in mapping the cortical networks that underlie awareness human brain, but knowledge about subcortical sustain humans incomplete. Here, we aimed to map connectivity a proposed network sustains wakefulness analogous default mode (DMN) shown contribute We integrated data from ex vivo diffusion magnetic resonance imaging (MRI) three brains, obtained at autopsy neurologically normal...
Abstract Diffusion MRI tractography allows in-vivo characterization of white matter architecture, including the localization and description brain fibre bundles. However, some primary bundles are still only partially reconstructed, or not reconstructed at all. The acoustic radiation (AR) represents a sensory pathway that has been largely omitted in many studies because its location anatomical features make it challenging to reconstruct. In this study, we investigated effects acquisition...
The development of scanners with ultra-high gradient strength, spearheaded by the Human Connectome Project, has led to dramatic improvements in spatial, angular, and diffusion resolution that is feasible for vivo MRI acquisitions. improved quality data can be exploited achieve higher accuracy inference both microstructural macrostructural anatomy. However, such high-quality only acquired on a handful Connectom worldwide, while remaining prohibitive clinical settings because constraints...
Limitations in the accuracy of brain pathways reconstructed by diffusion MRI (dMRI) tractography have received considerable attention. While technical advances spearheaded Human Connectome Project (HCP) led to significant improvements dMRI data quality, it remains unclear how these should be analyzed maximize accuracy. Over a period two years, we engaged community IronTract Challenge, which aims answer this question leveraging unique dataset. Macaque brains that both tracer injections and ex...
United States (US) Special Operations Forces (SOF) are frequently exposed to explosive blasts in training and combat, but the effects of repeated blast exposure (RBE) on SOF brain health incompletely understood. Furthermore, there is no diagnostic test detect injury from RBE. As a result, personnel may experience cognitive, physical, psychological symptoms for which cause never identified, they return or combat during period vulnerability. In 30 active-duty US SOF, we assessed relationship...
The human thalamus is a highly connected brain structure, which key for the control of numerous functions and involved in several neurological disorders. Recently, neuroimaging studies have increasingly focused on volume connectivity specific nuclei comprising this rather than looking at as whole. However, accurate identification cytoarchitectonically designed histological standard vivo structural MRI hampered by lack image contrast that can be used to distinguish from each other surrounding...
In humans, the occipital middle-temporal region (hMT + /V5) specializes in processing of visual motion, while planum temporale (hPT) auditory motion processing. It has been hypothesized that these regions might communicate directly to achieve fast and optimal exchange multisensory information. Here we investigated, for first time humans (male female), presence direct white matter connections between motion-selective using a combined fMRI diffusion MRI approach. We found evidence supporting...
Emerging evidence suggests that repeated blast exposure (RBE) is associated with brain injury in military personnel. United States (U.S.) Special Operations Forces (SOF) personnel experience high rates of during training and combat, but the effects low-level RBE on structure function SOF have not been comprehensively characterized. Further, pathophysiological link between RBE-related injuries cognitive, behavioral, physical symptoms has fully elucidated. We present a protocol for an...
Abstract Axon diameter and myelin thickness affect the conduction velocity of action potentials in nervous system. Imaging them non-invasively with MRI-based methods is thus valuable for studying brain microstructure function. Electron microscopy studies suggest that axon are closely related to each other. However, relationship between estimates these microstructural measures, known be relative indices, have not been investigated across mainly due methodological limitations. In recent years,...
Abstract Anatomic tracing is the gold standard tool for delineating brain connections and validating more recently developed imaging approaches such as diffusion MRI tractography. A key step in analysis of data from tracer experiments careful, manual charting fiber trajectories on histological sections. This a very time-consuming process, which limits amount annotated that are available validation studies. Thus, there need to accelerate this process by developing method computer-assisted...
Abstract Functional neuroimaging studies in neurotypical subjects correlate sentence comprehension to a left fronto-temporo-parietal network. Recent voxel-based lesion-symptom mapping (VLSM) of aphasia confirm the link between and posterior region including angular gyrus, supra-marginal gyrus postero-superior division temporal lobe but support pre-frontal involvement inconsistently. However, these focus on thematic role assignment without considering morphosyntactic processes. Hence,...
Brainstem white matter bundles are essential conduits for neural signaling involved in modulation of vital functions ranging from homeostasis to human consciousness. Their architecture forms the anatomic basis brainstem connectomics, subcortical mesoscale circuit models, and deep brain navigation tools. However, their small size complex morphology compared cerebral structures makes mapping segmentation challenging neuroimaging. This results a near absence automated tracing methods. We...
Consciousness is comprised of arousal (i.e., wakefulness) and awareness. Substantial progress has been made in mapping the cortical networks that modulate awareness human brain, but knowledge about subcortical sustain lacking. We integrated data from ex vivo diffusion MRI, immunohistochemistry, 7 Tesla functional MRI to map connectivity a network we postulate sustains wakefulness resting, conscious analogous default mode (DMN) believed self-awareness. identified nodes proposed ascending...
While many useful microstructural indices, as well orientation distribution functions, can be obtained from multi-shell dMRI data, there is growing interest in exploring the richer set of features that extracted full ensemble average propagator (EAP). The EAP readily computed diffusion spectrum imaging (DSI) at cost a very lengthy acquisition. Compressed sensing (CS) has been used to make DSI more practical by reducing its acquisition time. CS applied (CS-DSI) attempts reconstruct...
In vivo diffusion-weighted magnetic resonance imaging is limited in signal-to-noise-ratio (SNR) and acquisition time, which constrains spatial resolution to the macroscale regime. Ex imaging, allows for arbitrarily long scan times, critical exploring human brain structure mesoscale regime without loss of SNR. Standard head array coils designed patients are sub-optimal ex whole specimens. The goal this work was design construct a 48-channel coil high-resolution high b-value on 3T Connectome...