A5093089378- Traumatic Brain Injury and Neurovascular Disturbances
- Disaster Response and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Resilience and Mental Health
- Cardiac Arrest and Resuscitation
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Ethics in Clinical Research
- Traumatic Brain Injury Research
- Heart Rate Variability and Autonomic Control
- Advanced Neuroimaging Techniques and Applications
- Fibromyalgia and Chronic Fatigue Syndrome Research
Center for Neuro-Oncology
2024-2025
Massachusetts General Hospital
2024-2025
Harvard University
2024-2025
United States (US) Special Operations Forces (SOF) are frequently exposed to explosive blasts in training and combat, but the effects of repeated blast exposure (RBE) on SOF brain health incompletely understood. Furthermore, there is no diagnostic test detect injury from RBE. As a result, personnel may experience cognitive, physical, psychological symptoms for which cause never identified, they return or combat during period vulnerability. In 30 active-duty US SOF, we assessed relationship...
The Beirut Port Explosion of 4 August 2020 posed significant medical challenges for relief teams and caused diverse blast injuries to individuals in the area. Several days after explosion occurred, a Special Operations Forces (SOF) medic provided care Servicemember who developed neurologic symptoms that led his evacuation out Lebanon. These efforts underscore need vigilant post-blast monitoring consideration long-term consequences.
Emerging evidence from autopsy studies indicates that interface astroglial scarring (IAS) at the gray-white matter junction is a pathological signature of repeated blast brain injury in military personnel. However, there currently no
United States Special Operations Forces (SOF) personnel are frequently exposed to explosive blasts in training and combat. However, the effects of repeated blast exposure on human brain incompletely understood. Moreover, there is currently no diagnostic test detect injury (rBBI). In this "Human Performance Optimization" article, we discuss how development implementation a reliable for rBBI has potential promote SOF health, combat readiness, quality life.
Abstract United States Special Operations Forces (SOF) experience neurobehavioral symptoms that can adversely affect training and combat operations. Understanding the neurobiological basis for these may guide prevention treatment. In 29 male active-duty SOF with mean (SD) 17(4) years of service, we tested whether self-reported apathy, disinhibition, executive dysfunction measured by Frontal Systems Behavior Scale, were related to functional magnetic resonance imaging positron emission...
Abstract Emerging evidence from autopsy studies indicates that interface astroglial scarring (IAS) at the grey-white matter junction is a pathological signature of repeated blast brain injury in military personnel. However, there currently no neuroimaging test detects IAS, which major barrier to diagnosis, prevention, and treatment. In 27 active-duty United States Special Operations Forces personnel with high levels cumulative exposure, we performed translocator protein (TSPO) positron...
Structured acquisition and analysis of individual-level health data in the context biomedical research can yield novel results with potential clinical or personal relevance to participants. While approaches returning study participants civilian contexts has received some attention, unique ethical considerations informing sharing military results, particularly studies involving active-duty Special Operations Forces (SOF) personnel, have been underexplored. As number enrolling personnel grows,...