Modern modelling techniques may potentially provide more accurate predictions of binary outcomes than classical techniques. We aimed to study the predictive performance different in relation effective sample size ("data hungriness").We performed simulation studies based on three clinical cohorts: 1282 patients with head and neck cancer (with 46.9% 5 year survival), 1731 traumatic brain injury (22.3% 6 month mortality) 3181 minor (7.6% CT scan abnormalities). compared relatively modern...

Background: Delirium in hip fractured patients is a frequent complication. Dementia an important risk factor for delirium and common frail elderly. This study aimed to extend the previous knowledge on factors consequences. Special attention was given with dementia delirium. Methods: retrospective cohort performed Amphia Hospital, Breda, Netherlands. A full electronic patient file system (Hyperspace Version IU4: Epic, Inc., Verona, WI, USA) used assess data between January 2014 September...

To evaluate risk factors for postoperative delirium in a cohort of elderly hip-surgery patients and to validate medical stratification model.Prospective study.Medical school-affiliated general hospital Alkmaar, the Netherlands.Six hundred three aged 70 older screened delirium.Predefined were assessed on admission. One point was assigned each four present, resulting groups: low, intermediate, high risk. Baseline screening assessment included Mini-Mental State Examination, standardized Snellen...

<i>Background/Aims:</i> We obtained reference data for testicular volume measured by ultrasound in asymptomatic boys aged 0.5–18 years. In addition, we assessed the validity of Prader orchidometer per age group correlating it with measurement ultrasound. <i>Methods:</i> The study only included healthy two scrotal testes at birth and time examination. For each boy both was orchidometer. Testicular volumes were from 1 to 18 boys’ ages rounded down last birthday if had...

<i>Objective:</i> To study the outcome of delirium in elderly hip surgery patients. <i>Design:</i> Prospective matched controlled cohort study. Hip patients (n = 112) aged 70 years and older, who participated a clinical trial haloperidol prophylaxis for delirium, were followed an average 30 months after discharge. Patients with diagnosis dementia or mild cognitive impairment (MCI) identified using psychiatric interviews. Proportions dementia/MCI compared across had...

This is a discussion of issues in risk prediction based on the following papers: "Probability estimation with machine learning methods for dichotomous and multicategory outcome: Theory" by Jochen Kruppa, Yufeng Liu, Gérard Biau, Michael Kohler, Inke R. König, James D. Malley, Andreas Ziegler; Applications" Hans-Christian Diener, Theresa Holste, Christian Weimar, Ziegler.

The number of viral pathogens associated with pediatric acute respiratory tract infection (ARI) has grown since the introduction reverse transcription real-time polymerase chain reaction (RT-PCR) assays. Multiple viruses are detected during a single ARI episode in approximately quarter all cases. clinical relevance these multiple detections is unclear, as role individual virus. We therefore investigated correlation between data and RT-PCR results children single- ARI. Data from were...

<h3>Background</h3> Rectal measurement is considered a gold standard in many healthcare systems for body temperature children. Although this method has several disadvantages, an ideal alternative thermometer not yet been introduced. However tympanic and infrared skin thermometers are potential alternatives. <h3>Methods</h3> A prospective cohort study was performed including 100 children between 0 18 years of age admitted to the general paediatric ward Spaarne Hospital The Netherlands January...

Background: delirium after hip-surgery is associated with poor outcome. Few studies examined the mortality risk in elderly patients 1 year or more. Aim of this study was to examine hazard at 2-year follow-up, controlling for baseline factors and interaction effects. Methods: a secondary analysis based on data from controlled clinical trial evaluating efficacy haloperidol prophylaxis conducted large medical school-affiliated general hospital Alkmaar, The Netherlands. Randomised non-randomised...

Objective To determine whether prolonged urinary bladder catheterisation after vaginal prolapse surgery is advantageous. Design Randomised controlled trial. Setting A large training hospital in the Netherlands. Population Patients undergoing anterior colporrhaphy. Methods One hundred patients were included. randomised into two groups. In one group ( n = 50), a transurethral catheter was place for four days post‐operatively and removed on fifth post‐operative day. other not morning surgery....

OBJECTIVES: To examine the effects of general anesthesia on risk incident postoperative delirium in older adults undergoing hip surgery. DESIGN: Secondary analysis haloperidol prophylaxis for clinical trial data. Predefined factors were assessed prior to Primary outcome was delirium. Study compared across patient groups who received either or regional anesthesia, and individuals receiving various perioperative medications (benzodiazepines, anticholinergics, opioids), using multivariable...

Mitotic Activity Index (MAI) is an important independent prognostic factor and integral part of the breast cancer grading system. Thus, correct estimation this prognostically relevant feature essential for guiding treatment decision assessing patient prognosis. The aim study was to validate use high resolution Whole Slide Images (WSI) in estimating MAI specimens.MAI evaluated 100 consecutive specimens by three observers on two occasions, microscopically WSI with a wash out period 4 months....

For patients with haematological malignancies, information on disease, prognosis, treatment and impact quality of life is the utmost importance. To gain insight into perceived need for in relation to sociodemographic clinical parameters, comorbidity, (QoL) satisfaction, we compiled a questionnaire based existing validated questionnaires. A total 458 diagnosed malignancy participated. The was moderate high (40-70%). Multivariate regression analyses showed that higher related younger age,...

To assess gender differences in ankylosing spondylitis (AS) patients relation to tumor necrosis factor alpha inhibitor (TNFi) drug survival and occurrence of adverse events daily practice a large peripheral hospital.Retrospective data were collected from AS treated with etanercept, infliximab adalimumab between January 2004 2014. Kaplan-Meier curves conducted describe the time.Overall, 122 (60.7% male) included over 10-year time period, mean treatment period 51 months (1-127 months). In...

ObjectiveTo predict mortality with the Tilburg Frailty Indicator (TFI) in a sample of community-dwelling older people, using follow-up 7 years.DesignLongitudinal.Setting and Participants479 Dutch people aged 75 years or older.MeasurementsThe TFI, self-report questionnaire, was used to collect data about total, physical, psychological, social frailty. The municipality Roosendaal (a town Netherlands) provided dates.ResultsTotal, psychological frailty predicted mortality, unadjusted hazard...

A haematological malignancy is a serious, life-altering disease and may be characterised as an uncontrollable unpredictable stress situation. In dealing with potentially threatening information, individuals generally utilise two main cognitive coping styles: monitoring (the tendency to seek threat-relevant information) blunting (avoiding information seeking distraction). The aim of this study was obtain insight into the association between style (a) need for (b) satisfaction (c) involvement...

Objective: To investigate acute medical complications of alcohol intoxication among adolescents presenting to Reinier de Graaf Hospital, a major nonacademic hospital in Delft, the Netherlands. Methods: The frequency reduced consciousness, hypothermia, electrolyte disturbances, hypoglycemia, and acidosis along with was retrospectively studied records patients aged 11 17 years admitted between January 1, 2000, April 30, 2010. Results: Reduced consciousness (45%) hypothermia (43.1%) were most...