A5062206583- Atherosclerosis and Cardiovascular Diseases
- Gene Regulatory Network Analysis
- Scientific Computing and Data Management
- Lipoproteins and Cardiovascular Health
- Chemokine receptors and signaling
- Cell Adhesion Molecules Research
- Immune cells in cancer
- Simulation Techniques and Applications
- Cardiac Fibrosis and Remodeling
- Pancreatic and Hepatic Oncology Research
- Evolution and Genetic Dynamics
- Metabolomics and Mass Spectrometry Studies
- Mathematical Biology Tumor Growth
- Distributed and Parallel Computing Systems
- Single-cell and spatial transcriptomics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Health and Mental Health
- Pancreatitis Pathology and Treatment
- Signaling Pathways in Disease
- Physical Activity and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Biomedical Text Mining and Ontologies
- Neurogenesis and neuroplasticity mechanisms
Maastricht University
2012-2024
Maastricht University Medical Centre
2021-2022
University of Fribourg
2022
National Research Council
2022
European Organization for Nuclear Research
2015-2021
Azienda Ospedaliera G. Brotzu
2020
IRCCS Istituto Auxologico Italiano
2013
Ludwig-Maximilians-Universität München
2011-2012
University of Würzburg
2012
RWTH Aachen University
2012
Inflammation has been closely linked to auto-immunogenic processes in atherosclerosis. Plasmacytoid dendritic cells (pDCs) are specialized produce type-I interferons response pathogenic single-stranded nucleic acids, but can also sense self-DNA released from dying or neutrophil extracellular traps complexed the antimicrobial peptide Cramp/LL37 autoimmune disease. However, exact role of pDCs atherosclerosis remains elusive.Here we demonstrate that be detected murine and human atherosclerotic...
Unlike conventional dendritic cells, plasmacytoid DCs (PDC) are poor in antigen presentation and critical for type I interferon response. Though proposed to be present human atherosclerotic lesions, their role atherosclerosis remains elusive.To investigate the of PDC atherosclerosis.We show that scarcely lesions almost absent mouse plaques. Surprisingly, depletion by 120G8 mAb administration was seen promote plaque T-cell accumulation exacerbate lesion development progression LDLr⁻/⁻ mice....
In the setting of a six-month, open-label clinical trial, 141 consecutively enrolled, hypertensive, overweight patients were randomized to oral ingestion psyllium powder or guar gum 3.5 gr t.i.d., be taken 20 min before main two meals, standard diet. Both fibers improved significantly BMI, FPG, FPI, HOMA Index, HbA1c, LDL-C, and ApoB. Psyllium supplementation only exerted significant improvement in plasma TG concentration, SBP DBP. our study, six-month with fiber, but not fiber nor diet,...
Abstract Motivation Agent-based modeling is an indispensable tool for studying complex biological systems. However, existing simulation platforms do not always take full advantage of modern hardware and often have a field-specific software design. Results We present novel platform called BioDynaMo that alleviates both these problems. features modular high-performance engine. demonstrate can be used to simulate use cases in: neuroscience, oncology epidemiology. For each case, we validate our...
Recent clinical studies suggest that inflammatory mediators have huge potential in individualized therapy and efficacy screening can be utilized as biomarkers for a plethora of pathological conditions. The standard approach detecting measuring these is via blood samples. Nevertheless, there no scientific report providing solid evidence on the most suitable compartment will give optimal mediator measurement, or regarding diurnal variation circulating mediators. In this study, we present...
Low serum salivary amylase levels have been associated with a range of metabolic abnormalities, including obesity and insulin resistance. We recently suggested that low copy number at the AMY1 gene, lower enzyme levels, also increases susceptibility to obesity. To advance our understanding effect variation on metabolism, we compared metabolomic signatures high- low-copy carriers. analyzed, using mass spectrometry nuclear magnetic resonance (NMR), sera healthy normal-weight women carrying...
Abstract Motivation Agent-based modeling is an indispensable tool for studying complex biological systems. However, existing simulators do not always take full advantage of modern hardware and often have a field-specific software design. Results We present novel simulation platform called BioDynaMo that alleviates both these problems. features general-purpose high-performance engine. demonstrate can be used to simulate use cases in: neuroscience, oncology, epidemiology. For each case we...
This paper develops a three-dimensional in silico hybrid model of cancer, which describes the multi-variate phenotypic behaviour tumour and host cells. The encompasses role cell migration adhesion, influence extracellular matrix, effects oxygen nutrient availability, signalling triggered by chemical cues growth factors. proposed modelling framework combines successfully advantages continuum-based discrete methods, namely finite element agent-based method respectively. is thus used to...
Recent evidences suggest that modulation of vascular structure by matrix metalloproteinases (MMPs) could be a main determinant acute cardiovascular events in high-risk subjects. The authors consecutively selected 46 subjects affected familial combined hyperlipidemia (FCH), 44 metabolic syndrome (MS), FCH and MS, 40 healthy All these were firstly diagnosed not treated with lipid-lowering, antihypertensive, or antidiabetic drugs. A 12-h fasting blood sample was obtained from each patient,...
Intestinal ischemia-reperfusion injury is a serious and life-threatening condition. A better understanding of molecular mechanisms related to intestinal in human beings imperative find therapeutic targets improve patient outcome.First, the vivo dynamic modulation mucosal gene expression ischemia-reperfusion-injured small intestine was studied. Based on functional enrichment analysis changing transcriptome, one predominantly regulated pathways selected for further investigation an vitro...
Whether acute alcoholic pancreatitis occurs in a normal pancreas or that has already been altered by chronic is unclear. Our objective to clarify the relation between and histologic study of group patients having first attack pancreatitis.From January 1989 December 1999, 138 with pancreatitis, whom 28 had were seen us; 21 latter patients, it was attack. Of these 21, 6 underwent surgery for necrotic pancreatitis. In all adequate pancreatic biopsies obtained during surgery. Tissue samples...
CC chemokine ligands (CCLs) are elevated during acute coronary syndrome (ACS) and correlate with secondary events. Their involvement in plaque inflammation led us to investigate whether CCL3-5-18 linked the extent of artery disease (CAD) prognostic for primary events follow-up.We measured serum concentrations 712 patients chest discomfort referred cardiac CT angiography. Obstructive CAD was defined as ≥50 % stenosis. The by calcium score segment (number segments any CAD, range 0-16)....
We propose a mixed methods approach to digital ethnographic research. Treating online conversational environments as communities that ethnographers engage with in traditional fieldwork, we represent those conversations and the codes made by researchers thereon network form. call these networks “semantic social networks” (SSNs), they incorporate information on interaction their meaning perceived informants group use from science visualize data. present an application of this method large...
Idiopathic pancreatic hyperenzymemia is a new syndrome that characterized by chronic increase of serum enzymes in the absence disease. The aim this study was to assess whether mutations cystic fibrosis transmembrane conductance regulator (CFTR) gene may have role etiology hyperenzymemia.Seventy subjects with idiopathic hyperenzymemia, 44 men and 26 women (mean age, 48 years; range, 8-74 years), were studied. Thirteen these 70 had familial form syndrome. mutation analysis CFTR carried out...
Current research in the field of computational biology often involves simulations on high-performance computer clusters. It is crucial that code such efficient and correctly reflects model specifications. In this paper, we present an optimization strategy for agent-based biological dynamics using Intel Xeon Phi coprocessors, demonstrated by a prize-winning entry "Intel Modern Code Developer Challenge" competition. These optimizations allow simulating various mechanisms, particular simulation...