Cornelis H.C. Dejong
A5066911208- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Clinical Nutrition and Gastroenterology
- Diet and metabolism studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Colorectal Cancer Treatments and Studies
- Liver Disease and Transplantation
- Metabolism and Genetic Disorders
- Organ Transplantation Techniques and Outcomes
- Substance Abuse Treatment and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Obsessive-Compulsive Spectrum Disorders
- Eating Disorders and Behaviors
- Impact of Technology on Adolescents
- Enhanced Recovery After Surgery
- Muscle metabolism and nutrition
- Intestinal Malrotation and Obstruction Disorders
- Cardiac Ischemia and Reperfusion
- Abdominal vascular conditions and treatments
- Personality Disorders and Psychopathology
- Amino Acid Enzymes and Metabolism
Maastricht University
2014-2024
Radboud University Nijmegen
2008-2024
RWTH Aachen University
2017-2024
Universitätsklinikum Aachen
2017-2023
Maastricht University Medical Centre
1999-2023
University Medical Center Groningen
2023
Amsterdam University Medical Centers
2021
University of Amsterdam
1993-2021
St. Antonius Ziekenhuis
2014-2021
Erasmus MC
2021
Necrotizing pancreatitis with infected necrotic tissue is associated a high rate of complications and death. Standard treatment open necrosectomy. The outcome may be improved by minimally invasive step-up approach.In this multicenter study, we randomly assigned 88 patients necrotizing suspected or confirmed to undergo primary necrosectomy approach treatment. consisted percutaneous drainage followed, if necessary, retroperitoneal end point was composite major (new-onset multiple-organ failure...
Splanchnic hypoperfusion is common in various pathophysiological conditions and often considered to lead gut dysfunction. While it known that physiological situations such as physical exercise also result splanchnic hypoperfusion, the consequences of flow redistribution at expense abdominal organs remained be determined. This study focuses on effects gut, relationship between intestinal injury permeability during healthy men.Healthy men cycled for 60 minutes 70% maximum workload capacity....
Early enteral feeding through a nasoenteric tube is often used in patients with severe acute pancreatitis to prevent gut-derived infections, but evidence support this strategy limited. We conducted multicenter, randomized trial comparing early an oral diet at 72 hours after presentation the emergency department pancreatitis.
Infected necrotizing pancreatitis is a potentially lethal disease that treated with the use of step-up approach, catheter drainage often delayed until infected necrosis encapsulated. Whether outcomes could be improved by earlier unknown.
Glucagon-like peptide 1 (GLP-1) is a hormone released from enteroendocrine L cells. Although first described as glucoregulatory incretin hormone, GLP-1 also suppresses inflammation and promotes mucosal integrity. Here, we demonstrate that plasma levels are rapidly increased by lipopolysaccharide (LPS) administration in mice via Toll-like receptor 4 (TLR4)-dependent mechanism. Experimental manipulation of gut barrier integrity after dextran sodium sulfate treatment, or ischemia/reperfusion...
Previous randomized trials, including the Transluminal Endoscopic Step-Up Approach Versus Minimally Invasive Surgical in Patients With Infected Pancreatic Necrosis (TENSION) trial, demonstrated that endoscopic step-up approach might be preferred over surgical patients with infected necrotizing pancreatitis based on favorable short-term outcomes. We compared long-term clinical outcomes of both approaches after a period at least 5 years.In this follow-up study, we reevaluated all data 83 (of...
PURPOSE To compare outcomes after laparoscopic versus open major liver resection (hemihepatectomy) mainly for primary or metastatic cancer. The outcome measure was time to functional recovery. Secondary included morbidity, quality of life (QoL), and those with cancer, margin status adjuvant systemic therapy. PATIENTS AND METHODS This a multicenter, randomized controlled, patient-blinded, superiority trial on adult patients undergoing hemihepatectomy. Patients were recruited from 16 hospitals...
In Brief Objectives: To determine the relation between intestinal barrier dysfunction, bacterial translocation, and clinical outcome in patients with predicted severe acute pancreatitis influence of probiotics on these processes. Summary Background data: Randomized, placebo-controlled, multicenter trial probiotic prophylaxis (Ecologic 641) (PROPATRIA). Methods: Excretion fatty acid binding protein (IFABP, a parameter for enterocyte damage), recovery polyethylene glycols (PEGs, permeability),...
Glutamine plays an important role in nitrogen homeostasis and intestinal substrate supply. It has been suggested that glutamine is a precursor for arginine through intestinal-renal pathway involving inter-organ transport of citrulline. The importance metabolism endogenous synthesis humans, however, remained unaddressed. aim this study was to investigate the conversion citrulline effect liver on splanchnic humans. Eight patients undergoing upper gastrointestinal surgery received primed...
Infected necrotising pancreatitis is a potentially lethal disease that nearly always requires intervention. Traditionally, primary open necrosectomy has been the treatment of choice. In recent years, surgical step-up approach, consisting percutaneous catheter drainage followed, if necessary, by (minimally invasive) become standard care. A promising minimally invasive alternative endoscopic transluminal approach. This approach consists necrosectomy. We hypothesise less superior to in terms...
The guidelines for metastatic colorectal cancer crudely state that the best local treatment should be selected from a ‘toolbox’ of techniques according to patient- and treatment-related factors. We created an interdisciplinary, consensus-based algorithm with specific resectability ablatability criteria liver metastases (CRLM). To pursue consensus, members multidisciplinary COLLISION COLDFIRE trial expert panel employed RAND appropriateness method (RAM). Statements regarding patient, disease,...
Objective Lumen-apposing metal stents (LAMS) are believed to clinically improve endoscopic transluminal drainage of infected necrosis when compared with double-pigtail plastic stents. However, comparative data from prospective studies very limited. Design Patients necrotising pancreatitis, who underwent an step-up approach LAMS within a multicentre cohort study were the 51 patients in randomised TENSION trial had been assigned The clinical protocol was otherwise identical for both groups....