Daphne Roos
A5004980871- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Surgical Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Colorectal Cancer Screening and Detection
- Neuroendocrine Tumor Research Advances
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Appendicitis Diagnosis and Management
- Enhanced Recovery After Surgery
- Surgical site infection prevention
- Colorectal and Anal Carcinomas
- Surgical Simulation and Training
- Economic and Financial Impacts of Cancer
- Management of metastatic bone disease
- Biliary and Gastrointestinal Fistulas
- Airway Management and Intubation Techniques
- Ectopic Pregnancy Diagnosis and Management
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Cell Adhesion Molecules Research
Reinier de Graaf Hospital
2015-2024
Maastricht University
2016-2024
University Medical Center Utrecht
2016-2021
Jeroen Bosch Ziekenhuis
2019
OLVG
2009-2016
Radboud University Medical Center
2016
Leiden University Medical Center
2016
Radboud University Nijmegen
2016
Klinikum Mutterhaus der Borromäerinnen
2015
St. Antonius Ziekenhuis
2013
To assess whether laparoscopic cholecystectomy is superior to percutaneous catheter drainage in high risk patients with acute calculous cholecystitis.Multicentre, randomised controlled, superiority trial.11 hospitals the Netherlands, February 2011 January 2016.142 cholecystitis were randomly allocated (n=66) or (n=68). High was defined as an physiological assessment and chronic health evaluation II (APACHE II) score of 7 more.The primary endpoints death within one year occurrence major...
Objective: Our aim was to determine the prognostic significance of systemic-immune-inflammation index (SIII) in patients with resectable pancreatic cancer, using cancer-specific survival as primary outcome. Background: Pancreatic cancer is associated a dysfunctional immune system and poor prognosis. We examined SIII ductal adenocarcinoma (PDAC) effects bilirubin on this index. Methods: retrospectively assessed all resections performed between 2004 2015 at 4 tertiary referral centers identify...
Background: Textbook outcome (TO) is a multidimensional measure for quality assurance, reflecting the “ideal” surgical outcome. Methods: Post-hoc analysis of patients who underwent pancreatoduodenectomy (PD) or distal pancreatectomy (DP) all indications between 2014 and 2017, queried from nationwide prospective Dutch Pancreatic Cancer Audit. An international survey was conducted among 24 experts 10 countries to reach consensus on requirements TO in pancreatic surgery. Univariable...
Objective: To study the feasibility and impact of a nationwide training program in minimally invasive distal pancreatectomy (MIDP). Summary Background Data: Superior outcomes MIDP compared with open have been reported. In Netherlands (2005 to 2013) only 10% pancreatectomies were fashion 85% surgeons welcomed training. The is unknown. Methods: From 2014 2015, 32 pancreatic from 17 centers participated MIDP, including detailed technique description, video training, proctoring on-site. Outcomes...
We conducted a multicentre phase II trial to investigate feasibility and antitumor activity of sequential FOLFIRINOX Stereotactic Body Radiotherapy (SBRT) in patients with locally advanced pancreatic cancer (LAPC), (LAPC-1 trial).Patients biopsy-proven LAPC treated four hospitals the Netherlands between December 2014 June 2017. Patients received 8 cycles followed by SBRT (5 fractions/8 Gy) if no tumour progression after treatment was observed. Primary outcome 1-year overall survival (OS)....
Abstract Background The causal pathway between complications after pancreatic cancer resection and impaired long-term survival remains unknown. aim of this study was to investigate the impact on disease-free interval overall survival, with adjuvant chemotherapy as a mediator. Methods This observational included all patients undergoing in Netherlands (2014–2017). Clinical data were extracted from prospective Dutch Pancreatic Cancer Audit. Recurrence collected additionally. In mediation...
Abstract The fate of E-selectin expressed on TNF-activated monolayers HUVEC was investigated by confocal laser scanning microscopy. Cytokine-activated endothelial cells internalized mAb to in a very rapid, energy-dependent fashion. By contrast, against ICAM-1 and VCAM-1 remained surface bound. recovered intracellular compartments with tubular morphology, some which appeared be interconnected. Cathepsin B, ubiquitously lysosomal protease, found co-localize these structures. Functional...
Observational cohort studies have suggested that minimally invasive distal pancreatectomy (MIDP) is associated with better short-term outcomes compared open (ODP), such as less intraoperative blood loss, lower morbidity, shorter length of hospital stay, and reduced total costs. Confounding by indication has probably influenced these findings, given case-matched failed to confirm the superiority MIDP. This accentuates need for multicenter randomized controlled trials, which are currently...
The prognostic value of four proposed modifications to the 8th American Joint Committee on Cancer (AJCC) TNM staging system has yet be evaluated. This study aimed validate five modifications.Patients who underwent pancreatic ductal adenocarcinoma resection (2014-2016), as registered in prospective Dutch Pancreatic Audit, were included. Stratification and prognostication systems assessed using Kaplan-Meier curves, Cox proportional hazard analyses, C-indices. A new modification was composed...
Abstract Background Pancreatic resection is a major abdominal operation with 50% risk of postoperative complications. A common complication pancreatic fistula, which may have severe clinical consequences such as bleeding, organ failure and death. The objective this study to investigate whether implementation an algorithm for early detection minimally invasive management fistula improve outcomes after resection. Methods This nationwide stepped-wedge, cluster-randomized, superiority trial,...
BackgroundThis study aimed to identify predictors for early and very disease recurrence in patients undergoing resection of pancreatic ductal adenocarcinoma (PDAC) with without neoadjuvant therapy.MethodsIncluded were who underwent PDAC (2014–2016). Multivariable multinomial regression was performed preoperative manifestation within 3, 6 12 months after resection.Results836 a median follow-up 37 (interquartile range [IQR] 30–48) overall survival 18 (IQR 10-32) analyzed. 670 (80%) developed...
Abstract Background The number of elderly patients with pancreatic cancer is growing, however clinical data on the short-term outcomes, rate adjuvant chemotherapy, and survival in these are limited we therefore performed a nationwide analysis. Methods Data from prospective Dutch Pancreatic Cancer Audit were analyzed, including all undergoing resection between January 2014 December 2016. Patients classified into two age groups: <75 ≥75 years. Major complications (Clavien–Dindo grade 3 or...
Objective: To evaluate the performance of published fistula risk models by external validation, and to identify independent factors for postoperative pancreatic (POPF). Background: Multiple have been developed predict POPF after pancreatoduodenectomy. External validation in high-quality prospective cohorts is, however, lacking or only performed individual models. Methods: A post hoc analysis data from stepped-wedge cluster cluster-randomized Care After Pancreatic Resection According an...
Summary The purpose of this study was to prospectively examine the effectiveness and tolerability a simple radiotherapy technique for palliation symptomatic liver metastases. Twenty‐eight patients with metastases were enrolled from seven centres, received targeted (partial or whole) irradiation consisting 10 Gy in two fractions over 2 days. Symptoms at baseline hepatic pain (27 patients), abdominal distension (19), night sweats (12), nausea (18) vomiting (eight). Twenty‐two (76%) had failed...
Abstract Background Following several landmark trials, laparoscopic rectal resection has reached standard clinical practice. Current literature is undecided on the advantages of robotic and little known its learning curve. This study aimed to compare outcomes first 100 resections approach in a teaching hospital experienced colorectal surgery. Methods A retrospective analysis was conducted prospective cohort all consecutive between January 2012 September 2019 at single center. All cases were...
Abstract Background Venous resection of the superior mesenteric or portal vein is increasingly performed in pancreatic cancer surgery, whereas results studies on short- and long-term outcomes are contradictory. The aim this study was to evaluate impact type venous pancreatoduodenectomy for postoperative morbidity overall survival. Methods This nationwide retrospective cohort included all patients who underwent 18 centres (2013–2017). Results A total 1311 were included, whom 17 per cent wedge...