Daan J. Lips
A5065157263- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Screening and Detection
- Surgical Simulation and Training
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Esophageal and GI Pathology
- Colorectal Cancer Treatments and Studies
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
- Gastrointestinal Tumor Research and Treatment
- Anatomy and Medical Technology
- Colorectal and Anal Carcinomas
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Cardiac, Anesthesia and Surgical Outcomes
- Metastasis and carcinoma case studies
- Liver Disease Diagnosis and Treatment
- Intestinal and Peritoneal Adhesions
- MRI in cancer diagnosis
Medisch Spectrum Twente
2018-2025
Yahoo (United Kingdom)
2023
University Medical Center Utrecht
2006-2023
Meander Medisch Centrum
2023
Erasmus MC Cancer Institute
2022
University of Groningen
2022
Jeroen Bosch Ziekenhuis
2009-2021
Erasmus MC
2021
MSD (Netherlands)
2021
OLVG
2016
The aim of this study was to develop an alternative fistula risk score (a-FRS) for postoperative pancreatic (POPF) after pancreatoduodenectomy, without blood loss as a predictor.Blood loss, one the predictors original-FRS, not significant factor during 2 recent external validations.The a-FRS developed in databases: Dutch Pancreatic Cancer Audit (18 centers) and University Hospital Southampton NHS. Primary outcome grade B/C POPF according 2005 International Study Group on Surgery (ISGPS)...
The oncological safety of minimally invasive surgery has been questioned for several abdominal cancers. Concerns also exist regarding the use distal pancreatectomy (MIDP) in patients with resectable pancreatic cancer as randomised trials are lacking.In this international non-inferiority trial, we recruited adults from 35 centres 12 countries. Patients were randomly assigned to either MIDP (laparoscopic or robotic) open (ODP). Both and pathologists blinded approach. Primary endpoint was...
To assess short-term outcomes after minimally invasive (laparoscopic, robot-assisted, and hybrid) pancreatoduodenectomy (MIPD) versus open (OPD) among European centers.Current evidence on MIPD is based national registries or single expert centers. International, matched studies comparing for OPD are lacking.Retrospective propensity score study in 14 centers (7 countries) performing ≥10 MIPDs annually (2012-2017) 53 German/Dutch surgical registry OPDs (2014-2017). Primary outcome was 30-day...
Objective: The aim of the study was to assess feasibility and outcomes a multicenter training program in laparoscopic pancreatoduodenectomy (LPD). Background: Whereas expert centers have reported promising LPD, nationwide analyses raised concerns on its safety, especially during learning curve. Multicenter, structured LPD programs reporting including first procedures are lacking. No had been performed Netherlands before this study. Methods: During 2014–2016, 8 surgeons from 4 high-volume...
Objective: To study the feasibility and impact of a nationwide training program in minimally invasive distal pancreatectomy (MIDP). Summary Background Data: Superior outcomes MIDP compared with open have been reported. In Netherlands (2005 to 2013) only 10% pancreatectomies were fashion 85% surgeons welcomed training. The is unknown. Methods: From 2014 2015, 32 pancreatic from 17 centers participated MIDP, including detailed technique description, video training, proctoring on-site. Outcomes...
To assess feasibility and safety of a multicenter training program in robotic pancreatoduodenectomy (RPD) adhering to the IDEAL framework for implementation surgical innovation.Good results RPD have been reported from single center studies. However, data on through are lacking.A was designed together with University Pittsburgh Medical Center, including an online video bank, robot simulation exercises, biotissue drills, on-site proctoring. Benchmark patients were based criteria Clavien....
Beyond demographic and immune factors, metabolic considerations, particularly metformin's recognized impact in oncology, warrant exploration treating pancreatic cancer. This study aimed to investigate the influence of metformin on patient survival its potential correlation with distinct profiles ductal adenocarcinoma (PDAC) tumors.
Data from observational studies suggest that minimally invasive pancreatoduodenectomy (MIPD) is superior to open regarding intraoperative blood loss, postoperative morbidity, and length of hospital stay, without increasing total costs. However, several case-matched failed demonstrate superiority MIPD, large registry the USA even suggested increased mortality for MIPDs performed in low-volume (<10 annually) centers. Randomized controlled multicenter trials are lacking but clearly required. We...
To assess the feasibility, proficiency, and mastery learning curves for robotic pancreatoduodenectomy (RPD) in "second-generation" RPD centers following a multicenter training program adhering to IDEAL framework.The long reported from "pioneering" expert may discourage interested starting an program. However, be shorter that participated dedicated programs, although data are lacking. We report on trained nationwide program.Post hoc analysis of all consecutive patients undergoing 7 LAELAPS-3...
Minimally invasive pancreatoduodenectomy (MIPD) aims to reduce the negative impact of surgery as compared open (OPD) and is increasingly becoming part clinical practice for selected patients worldwide. However, safety MIPD remains a topic debate potential shorter time functional recovery needs be confirmed. To guide safe implementation MIPD, large-scale international randomized trials comparing OPD in experienced high-volume centers are needed. We hypothesize that non-inferior terms overall...
Abstract Background Although robotic pancreatoduodenectomy has shown promising outcomes in experienced high-volume centres, it is unclear whether implementation on a nationwide scale safe and beneficial. The aim of this study was to compare the early experience with versus open Netherlands. Methods This retrospective cohort all consecutive patients who underwent or were registered mandatory Dutch Pancreatic Cancer Audit (18 2014–2021), starting from first procedure per centre. main endpoints...
Abstract Background Minimally invasive pancreatoduodenectomy (MIPD) is increasingly being performed because of perceived patient benefits. Whether conversion MIPD to open worsens outcome, and which risk factors are associated with conversion, unclear. Methods This was a post hoc analysis European multicentre retrospective cohort study patients undergoing (2012–2017) in ten medium-volume (10–19 MIPDs annually) four high-volume (at least 20 centres. Propensity score matching (1 : 1) used...
Abstract Background Recently, the first randomized trials comparing minimally invasive distal pancreatectomy (MIDP) with open (ODP) for non-malignant and malignant disease showed a 2-day reduction in time to functional recovery after MIDP. However, pancreatic ductal adenocarcinoma (PDAC), concerns have been raised regarding oncologic safety (i.e., radical resection, lymph node retrieval, survival) of MIDP, as compared ODP. Therefore, controlled trial MIDP ODP PDAC oncological is warranted....
Glucose control in patients after total pancreatectomy is problematic because of the complete absence α- and β-cells, leading to impaired quality life. A novel, bihormonal artificial pancreas (BIHAP), using both insulin glucagon, may improve glucose control, but studies this setting are lacking.To assess efficacy safety BIHAP pancreatectomy.This randomized crossover clinical trial compared fully closed-loop with current diabetes care (ie, pump or pen therapy) 12 adult outpatients...
Objective: To determine the nationwide implementation and surgical outcome of minor major robotic liver surgery (RLS) assess first phase RLS during learning curve. Background: may be a valuable alternative to laparoscopic surgery. Nationwide population-based studies with data on are lacking. Methods: Multicenter retrospective cohort study including consecutive patients who underwent for all indications in 9 Dutch centers (August 2014–March 2021). Data resections were obtained from mandatory...
Difficulty scoring systems are important for the safe, stepwise implementation of new procedures. We designed a retrospective observational study building difficulty score robotic pancreatoduodenectomy.The (PD-ROBOSCORE) aims at predicting severe postoperative complications after pancreatoduodenectomy. The PD-ROBOSCORE was developed in training cohort 198 pancreatoduodenectomies and validated an international multicenter 686 pancreatoduodenectomies. Finally, all centers tested model during...
Unintended tumor-positive resection margins occur frequently during minimally invasive surgery for colorectal liver metastases and potentially negatively influence oncologic outcomes.