A5017479676- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pancreatitis Pathology and Treatment
- COVID-19 Impact on Reproduction
- Liver Disease Diagnosis and Treatment
- Zebrafish Biomedical Research Applications
- Liver Diseases and Immunity
- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- COVID-19 and healthcare impacts
- Pregnancy and Medication Impact
- Lung Cancer Research Studies
- COVID-19 Clinical Research Studies
- Vaccine Coverage and Hesitancy
- Neuroendocrine Tumor Research Advances
- Brain Metastases and Treatment
- Cancer-related Molecular Pathways
- Complement system in diseases
Erasmus University Rotterdam
2023-2025
Erasmus MC
2020-2025
Erasmus MC Cancer Institute
2022-2024
Beyond demographic and immune factors, metabolic considerations, particularly metformin's recognized impact in oncology, warrant exploration treating pancreatic cancer. This study aimed to investigate the influence of metformin on patient survival its potential correlation with distinct profiles ductal adenocarcinoma (PDAC) tumors.
Background This study investigates sex disparities in clinical outcomes and tumour immune profiles patients with pancreatic ductal adenocarcinoma (PDAC) who underwent upfront resection or preceded by gemcitabine-based neoadjuvant chemoradiotherapy (nCRT). Methods Patients originated from the PREOPANC randomised controlled trial. Upfront surgery was performed 82 patients, 66 received nCRT before resection. The impact of on overall survival (OS) investigated using Cox proportional hazards...
This study underscores GATA6's role in distinguishing classical and basal-like pancreatic ductal adenocarcinoma (PDAC) phenotypes. Retrospective studies associate GATA6 immunohistochemistry (IHC) expression with survival outcomes, warranting prospective validation. In a treatment-naive cohort of patients resected PDAC, IHC proves prognostic discriminator, associating high extended the PDAC phenotype. However, significance is numerically lower after gemcitabine-based neoadjuvant...
Amid the need for new approaches to improve survival in pancreatic ductal adenocarcinoma (PDAC), immune-based therapies have garnered interest. Rintatolimod, a Toll-like receptor 3 (TLR-3) agonist, is potential candidate due its dual impact on restraining PDAC cell functions and boosting antitumor immune response. This study investigates effect of TLR-3 activation through rintatolimod peripheral landscape patients with advanced PDAC.
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection in the placenta can lead to fetal distress and demise, characterized by severe trophoblast necrosis, chronic histiocytic intervillositis (CHI), massive perivillous fibrin deposition. We aimed uncover spatial immune‐related protein changes SARS‐CoV‐2 placentitis compared with CHI placentas uncomplicated pregnancies gain insight into underlying pathophysiological mechanisms. Placentas were retrospectively collected...
Granulomatous disease affects up to 20% of patients with Common Variable Immunodeficiency (CVID). Granulomas are comprised highly activated immune cells, and emerge in response antigenic triggers. In CVID granulomas however, the underlying pathophysiology is unclear specific trigger remains unknown. Granuloma formation often compared sarcoidosis, although clinical context prognosis differ, suggesting a different pathogenesis. The aim this study was investigate if cellular organization...
Abstract The first hematopoietic stem cells (HSCs) are formed through endothelial-to-hematopoietic transition (EHT) during embryonic development. transcription factor GATA2 is a crucial regulator of EHT and HSC function throughout life. Because patients with haploinsufficiency have inborn mutations, prenatal defects likely to influence disease In mice, Gata2 (Gata2+/−) reduces the number functionality progenitor (HSPCs) generated EHT. However, HSPC pool heterogeneous mechanisms underlying...
Metastases in the brain are most severe and devastating complication of cancer. The incidence metastasis is increasing. Therefore, need finding specific druggable targets for demanding. aim this study was to compare (immune) response metastases common tumor lineages, viz., lung adenocarcinoma breast Targeted gene expression profiles 11 (BM-LUAD) were compared cancer (BCBM) using NanoString nCounter PanCancer IO 360™ Panel. promising results validated spatially novel GeoMx™ Digital Spatial...
<title>Abstract</title> Granulomatous disease affects up to 20% of patients with common variable immunodeficiency (CVID). Granulomas are comprised highly activated immune cells, and emerge in response antigenic triggers. In CVID granulomas however, the underlying pathophysiology is unclear specific trigger remains unknown. Granuloma formation often compared sarcoidosis, although clinical context prognosis differ, suggesting a different pathogenesis. The aim this study was investigate if...
<div>AbstractPurpose:<p>Amid the need for new approaches to improve survival in pancreatic ductal adenocarcinoma (PDAC), immune-based therapies have garnered interest. Rintatolimod, a Toll-like receptor 3 (TLR-3) agonist, is potential candidate due its dual impact on restraining PDAC cell functions and boosting antitumor immune response. This study investigates effect of TLR-3 activation through rintatolimod peripheral landscape patients with advanced PDAC.</p>Experimental...
<div>AbstractPurpose:<p>Amid the need for new approaches to improve survival in pancreatic ductal adenocarcinoma (PDAC), immune-based therapies have garnered interest. Rintatolimod, a Toll-like receptor 3 (TLR-3) agonist, is potential candidate due its dual impact on restraining PDAC cell functions and boosting antitumor immune response. This study investigates effect of TLR-3 activation through rintatolimod peripheral landscape patients with advanced PDAC.</p>Experimental...
<p>Supplementary Figure S1. Gating strategy of flow cytometry analyses on blood samples. Two panels were designed to investigate the presence and activation peripheral T cells, DCs, myeloid cells. The top-row gating was applied in all panels.</p>
<p>Supplementary Figure S3. Transcriptomic NanoString analysis for delta values (after mRNA counts – baseline counts). (A) t-SNE plot illustrates no apparent segregation of changes among 730 immune-related genes based on treatment response. (B) Boxplots displaying significant DE between stable and progressive disease patients upon rintatolimod treatment. The x-axis represents different genes, the y-axis log2 gene expression count.</p>
<p>Supplementary Figure S2. Relative abundance of peripheral immune cells. (A-D) Boxplots illustrating the differences in cell scores between baseline and post-rintatolimod (A), progressive disease stable patients at (B), (C), delta change (D). The x-axis displays different subsets, y-axis score or (upper right).</p>
<p>Supplementary Figure S1. Gating strategy of flow cytometry analyses on blood samples. Two panels were designed to investigate the presence and activation peripheral T cells, DCs, myeloid cells. The top-row gating was applied in all panels.</p>
<p>Supplementary Figure S2. Relative abundance of peripheral immune cells. (A-D) Boxplots illustrating the differences in cell scores between baseline and post-rintatolimod (A), progressive disease stable patients at (B), (C), delta change (D). The x-axis displays different subsets, y-axis score or (upper right).</p>
<p>Supplementary Figure S3. Transcriptomic NanoString analysis for delta values (after mRNA counts – baseline counts). (A) t-SNE plot illustrates no apparent segregation of changes among 730 immune-related genes based on treatment response. (B) Boxplots displaying significant DE between stable and progressive disease patients upon rintatolimod treatment. The x-axis represents different genes, the y-axis log2 gene expression count.</p>
Abstract The first hematopoietic stem cells (HSCs) are formed through endothelial-to-hematopoietic transition (EHT) events during embryonic development. transcription factor GATA2 is a crucial regulator of EHT and HSC function throughout life. Because haploinsufficiency patients have inborn mutations, prenatal defects likely to an influence on disease In mice, Gata2 ( +/- ) reduces the number functionality progenitor (HSPCs) generated EHT. However, HSPC pool heterogeneous mechanisms...