A5101765635- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Cardiovascular and Diving-Related Complications
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Ultrasound in Clinical Applications
- Pulmonary Hypertension Research and Treatments
- Cardiac pacing and defibrillation studies
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac tumors and thrombi
- Cardiomyopathy and Myosin Studies
- Pericarditis and Cardiac Tamponade
- Cardiac electrophysiology and arrhythmias
- COVID-19 and healthcare impacts
- Obstructive Sleep Apnea Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Phonocardiography and Auscultation Techniques
- ECG Monitoring and Analysis
- Cardiac and Coronary Surgery Techniques
- Streptococcal Infections and Treatments
Imperial College London
2020-2025
Imperial College Healthcare NHS Trust
2019-2025
Hammersmith Hospital
2020-2024
Cleveland Clinic London
2024
Lung Institute
2021
Charing Cross Hospital
2021
Papworth Hospital NHS Foundation Trust
2010-2020
Papworth Hospital
2011-2020
Cambridge University Health Partners
2018-2019
Cambridge University Hospitals NHS Foundation Trust
2015-2017
Abstract Pulmonary hypertension is defined as a mean arterial pressure of ≥25 mmHg confirmed on right heart catheterisation. Traditionally, the pulmonary systolic has been estimated echo by utilising simplified Bernoulli equation from peak tricuspid regurgitant velocity and adding this to an estimate atrial pressure. Previous studies have demonstrated correlation between that obtained invasive measurement across cohort patients. However, for individual patient significant overestimation...
Transcatheter aortic valve implantation (TAVI) is a less invasive alternative to surgical replacement and the treatment of choice for patients at high operative risk. The role TAVI in lower risk unclear.To determine whether noninferior surgery moderately increased risk.In this randomized clinical trial conducted 34 UK centers, 913 aged 70 years or older with severe, symptomatic stenosis due age comorbidity were enrolled between April 2014 2018 followed up through 2019.TAVI using any CE mark...
BackgroundMost patients who have heart failure with a reduced ejection fraction, when left ventricular fraction (LVEF) is 40% or lower, are diagnosed in hospital. This despite previous presentations to primary care symptoms. We aimed test an artificial intelligence (AI) algorithm applied single-lead ECG, recorded during ECG-enabled stethoscope examination, validate potential point-of-care screening tool for LVEF of lower.MethodsWe conducted observational, prospective, multicentre study...
Abstract Impairment of left ventricular (LV) diastolic function is common amongst those with heart disease and associated significant morbidity. Given that, in simple terms, the ventricle can only eject volume which it fills that approximately one half hospitalisations for failure (HF) are normal/’preserved’ ejection fraction (HFpEF) (Bianco et al. JACC Cardiovasc Imaging. 13:258–271, 2020. 10.1016/j.jcmg.2018.12.035), where abnormalities filling cause symptoms, clear assessment (LVDF)...
There have been significant advances in the field of echocardiography with introduction a number new techniques into standard clinical practice. Consequently, 'standard' echocardiographic examination has evolved to become more detailed and time-consuming that requires high level expertise. This Guideline produced by British Society Echocardiography (BSE) Education Committee aims provide minimum dataset should be obtained comprehensive echocardiogram. In addition, layout proposes recommended...
Paravalvular leak (PVL) occurs in 5% to 17% of patients following surgical valve replacement. Percutaneous device closure represents an alternative repeat surgery.All UK and Ireland centers undertaking percutaneous PVL submitted data the Registry. Data were analyzed for association with death major adverse cardiovascular events (MACE) at follow-up.Three hundred eight procedures attempted 259 20 (2004-2015). Patient age was 67±13 years; 28% female. The main indications heart failure (80%)...
Postinfarction ventricular septal defect carries a grim prognosis. Surgical repair offers reasonable outcomes in patients who survive healing phase. Percutaneous device implantation represents potentially attractive early alternative.Postinfarction closure was attempted 53 from 11 centers (1997-2012; aged 72±11 years; 42% female). Nineteen percent had previous surgical closure. Myocardial infarction anterior (66%) or inferior (34%). Time myocardial to procedure 13 (first and third quartiles,...
Since cardiac ultrasound was introduced into medical practice around the middle twentieth century, transthoracic echocardiography has developed to become a highly sophisticated and widely performed imaging modality in diagnosis of heart disease. This evolution from an emerging technique with limited application, complex capable detailed assessment been driven by technological innovations that have both refined 'standard' 2D Doppler led development new diagnostic techniques. Accordingly,...
Heart failure (HF) is a debilitating and life-threatening condition, with 5-year survival rate lower than breast or prostate cancer. It the leading cause of hospital admission in over 65s, these admissions are projected to rise by more 50% next 25 years. Transthoracic echocardiography (TTE) first-line step diagnosis acute chronic HF provides immediate information on chamber volumes, ventricular systolic diastolic function, wall thickness, valve function presence pericardial effusion, while...
Functional mitral regurgitation (FMR) is a consequence of annular enlargement, leaflet tethering and reduced co-aptation. The importance the left atrium (LA) as cause (MR) less clear. We applied co-aptation index using three-dimensional (3D) transoesophageal echocardiography to FMR MR secondary LA dilatation (atrial regurgitation, AMR). Seventy-two patients underwent comprehensive 3D echo studies: (n = 19); AMR 33); 20 controls. recorded: LV size function; dimensions; area (MVA); in early...
Mitral valve disease is common. regurgitation the second most frequent indication for surgery in Europe and despite decline of rheumatic fever Western societies, mitral stenosis any aetiology a regular finding all echo departments. is, therefore, one common pathologies encountered by echocardiographers, as both primary echocardiography secondary when investigating other cardiovascular processes. Transthoracic, transoesophageal exercise stress play crucial role assessment are essential to...
The guideline provides a practical step-by-step guide in order to facilitate high-quality echocardiographic studies of patients with aortic stenosis. In addition, it addresses commonly encountered yet challenging clinical scenarios and covers the use advanced techniques, including TOE Dobutamine stress echocardiography assessment
Echocardiography is the commonest medical ultrasound examination, but automated interpretation challenging and hinges on correct recognition of 'view' (imaging plane orientation). Current state-of-the-art methods for identifying view computationally involve 2-dimensional convolutional neural networks (CNNs), these merely classify individual frames a video in isolation, ignore information describing movement structures throughout cardiac cycle. Here we explore efficacy novel CNN...
Abstract Transthoracic echocardiography is the first-line imaging modality in assessment of right-sided valve disease. The principle objectives echocardiographic study are to determine aetiology, mechanism and severity valvular dysfunction, as well consequences on right heart remodelling estimations pulmonary artery pressure. Echocardiographic data must be integrated with symptoms, inform optimal timing technique interventions. most common tricuspid abnormality regurgitation secondary...
Objectives The clinical impact of SARS-CoV-2 has varied across countries with varying cardiovascular manifestations. We review the cardiac presentations, in-hospital outcomes and development complications in initial cohort positive patients at Imperial College Healthcare National Health Service Trust, UK. Methods retrospectively analysed 498 COVID-19 adult admissions to our institute from 7 March April 2020. Patient data were collected for baseline demographics, comorbidities outcomes,...
<b>Objectives:</b> To study serial measures of maximum QT interval corrected for heart rate (QTc) and dispersion (QTD) their association with cardiac mortality patients non-insulin dependent diabetes to compare abnormalities other predictors (ankle brachial pressure index (ABPI) autonomic function tests) in ability predict death. <b>Setting:</b> Teaching hospital. <b>Methods patients:</b> analysis, (RR) variation response deep breathing standing, ABPI were analysed 192 diabetes. Cardiac...
Background: Artificial intelligence (AI) for echocardiography requires training and validation to standards expected of humans. We developed an online platform established the Unity Collaborative build a dataset expertise from 17 hospitals training, validation, standardization such techniques. Methods: The consisted 2056 individual frames drawn at random 1265 parasternal long-axis video-loops patients undergoing clinical in 2015 2016. Nine experts labeled these images using our platform....