A5022925757- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- ECG Monitoring and Analysis
- Cardiac Arrhythmias and Treatments
- Viral Infections and Immunology Research
- Coronary Interventions and Diagnostics
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Ion channel regulation and function
- Congenital heart defects research
- Cardiac Valve Diseases and Treatments
- Pericarditis and Cardiac Tamponade
- Genetic Associations and Epidemiology
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Advanced MRI Techniques and Applications
- Sarcoidosis and Beryllium Toxicity Research
- Ultrasound in Clinical Applications
- Renin-Angiotensin System Studies
- Long-Term Effects of COVID-19
- Vasculitis and related conditions
Imperial College Healthcare NHS Trust
2015-2025
Hammersmith Hospital
2019-2025
Imperial College London
2017-2025
National Health Service
2021
University College London
1997-2020
Barts Health NHS Trust
2020
Virginia Commonwealth University
2019
West Hertfordshire Hospitals NHS Trust
2012-2017
Medtronic (United Kingdom)
2017
St Mary's Hospital
2012-2014
In vivo studies with intravascular ultrasound have shown that complex plaque anatomy and rupture are more frequent in the presence of marked outward remodeling. A large lipid core a high macrophage count recognized histological markers for vulnerability. The link between vulnerability terms these remodeling coronary arteries has not been explored.In 88 male subjects who died suddenly artery disease, 108 plaques were studied. percent was calculated. Lesions > or = 0% considered to positive...
<h3>OBJECTIVE</h3> To make a quantitative assessment of the relation between disarray, fibrosis, and small vessel disease in hypertrophic cardiomyopathy. <h3>DESIGN</h3> Detailed macroscopic histological examination at 19 segments left right ventricle atrial free wall. <h3>PATIENTS</h3> 72 patients with cardiomyopathy who had suffered sudden death or progression to end stage cardiac failure (resulting heart transplantation). <h3>MAIN OUTCOME MEASURES</h3> The presence scarring, dilatation,...
Reports on the incidence and causes of sudden cardiac death among young athletes have relied largely estimated rates participation varied methods reporting. We sought to investigate adolescent soccer players in United Kingdom.
Background The absence (deletion allele [ D ]) of a 287–base pair marker in the ACE gene is associated with higher levels than its presence (insertion I ]). If renin-angiotensin systems regulate left ventricular (LV) growth, then individuals DD genotype might show greater hypertrophic response those II genotype. We tested this hypothesis by studying exercise-induced LV hypertrophy. Methods and Results Echocardiographically determined dimensions mass (n=140), electrocardiographically...
Background — Patients with hypertrophic cardiomyopathy (HCM) are at increased risk of premature death; this is particularly apparent for patients mutations the troponin T gene. Myocyte disarray and interstitial fibrosis, pathological features HCM, may be determinants in these deaths. The relation between genotype, phenotype, mode death has not been explored. Methods Results Seventy-five hearts HCM were examined. DNA was available 50 screening macroscopic findings, percentage disarray,...
<h3>Objective</h3> Myocardial fibrosis identified by late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) in patients with hypertrophic cardiomyopathy (HCM) is associated adverse events, but its value as an independent risk factor for sudden cardiac death (SCD) unknown. We investigated the role of LGE-CMR stratification HCM. <h3>Methods</h3> conducted a prospective cohort study tertiary referral centre. Consecutive HCM (n=711, median age 56.3 years, IQR 46.7–66.6; 70.0%...
To screen for a mutation of the cardiac troponin T gene in two families where there had been sudden deaths without an increase left ventricular mass but with myocardial disarray suggesting hypertrophic cardiomyopathy.DNA from affected individuals both was used to on exon by basis. Mutation screening achieved polymerase chain reaction and direct sequencing. Where appropriate, confirmed restriction digest.A novel missense 9 found one families. This at amino acid 94 resulted substitution...
Objectives The clinical impact of SARS-CoV-2 has varied across countries with varying cardiovascular manifestations. We review the cardiac presentations, in-hospital outcomes and development complications in initial cohort positive patients at Imperial College Healthcare National Health Service Trust, UK. Methods retrospectively analysed 498 COVID-19 adult admissions to our institute from 7 March April 2020. Patient data were collected for baseline demographics, comorbidities outcomes,...
Background: Early discharge after myocardial infarction is safe and feasible. Factors that delay need to be identified in order improve care reduce bed occupancy. Objective: To investigate the potential of restricted weekend service operates most hospitals patient discharge. Design: Prospective cohort study. Subjects setting: 2541 consecutive patients with acute admitted coronary unit three local district over a 12 year period. Results: Clinical factors affecting duration stay were age, sex,...
Abstract Background Brugada syndrome is rare but important to diagnose due its predisposition sudden death. Deep neural networks can be trained automate the recognition of diagnostic type 1 ECG pattern on a 12-lead with variable performance reported previously. The scarcity high quality training data hinders development robust and accurate AI models in case as well for other cardiac conditions. Purpose We tested effectiveness various representation learning approaches pretraining...