A5030190234- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Sports injuries and prevention
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Congenital Heart Disease Studies
- Cardiovascular and exercise physiology
- Viral Infections and Immunology Research
- Acute Myocardial Infarction Research
- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Cardiac Health and Mental Health
- Cardiovascular Issues in Pregnancy
- Cardiac Arrest and Resuscitation
- Sports Performance and Training
- Connective tissue disorders research
- Pulmonary Hypertension Research and Treatments
- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Health Promotion and Cardiovascular Prevention
- Advanced MRI Techniques and Applications
- Electrostatic Discharge in Electronics
Royal Brompton Hospital
2018-2025
Royal Brompton & Harefield NHS Foundation Trust
2020-2025
Imperial College London
2020-2025
St George's, University of London
2014-2024
St George’s University Hospitals NHS Foundation Trust
2022-2024
Newcastle University
2024
British Heart Foundation
2022
University of Leeds
2022
Harefield Hospital
2018-2022
Guy's and St Thomas' NHS Foundation Trust
2014-2022
The ESC Guidelines represent the views of and were produced after careful consideration scientific medical knowledge evidence available at time their publication.The is not responsible in event any contradiction, discrepancy and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies.Health professionals are encouraged take fully into account when exercising clinical...
<h3>Abstract</h3> The early evolutionary history of the armoured dinosaurs (Thyreophora) is obscured by its patchily distributed fossil record and conflicting views on relationships Early Jurassic representatives. Here, we describe an early-diverging thyreophoran from Lower Fengjiahe Formation Yunnan Province, China, basis associated partial skeleton that includes skull, axial, limb armour elements. It can be diagnosed as a new taxon based numerous cranial postcranial autapomorphies further...
Recent efforts have focused on improving the specificity of European Society Cardiology (ESC) criteria for ECG interpretation in athletes. These are derived predominantly from white athletes (WAs) and do not account effect Afro-Caribbean ethnicity or novel research questioning relevance several isolated patterns. We assessed impact ESC criteria, newly published Seattle a group proposed refined large cohort black (BAs) WAs. Between 2000 2012, 1208 BAs were evaluated with history, examination,...
Background— Patients with heart failure and chronic anemia frequently demonstrate left ventricular (LV) trabeculations, which may be compatible the diagnosis of LV noncompaction. We used pregnancy model, is characterized by a reversible increase in cardiac preload other changes function, to assess development de novo trabeculations women morphologically normal hearts. Methods Results— One hundred two primigravida pregnant were evaluated longitudinally series echocardiograms first trimester,...
Reports on the incidence and causes of sudden cardiac death among young athletes have relied largely estimated rates participation varied methods reporting. We sought to investigate adolescent soccer players in United Kingdom.
Regular, intensive exercise results in physiological biventricular cardiac adaptation. Ethnicity is an established determinant of left ventricular remodeling; black athletes (BAs) exhibit more profound LV hypertrophy than white (WAs). Right (RV) remodeling has not been characterized BAs, although the issue pertinent because BAs commonly ECG anomalies that resemble arrhythmogenic RV cardiomyopathy.Between 2006 and 2012, 300 consecutive (n=243 males) from 25 sporting disciplines were evaluated...
Background/aims Adult black athletes (BA) exhibit left ventricular hypertrophy (LVH) on echocardiography and marked ECG repolarisation changes resembling those observed in hypertrophic cardiomyopathy (HCM). Limited data are available for adolescent BA, the group most vulnerable to exercise-related sudden cardiac death. Methods Between 1996 2011, 245 male 84 female BA from a wide variety of sporting disciplines underwent evaluation including echocardiography. Athletes exhibiting T-wave...
The 2010 European Society of Cardiology (ESC) guidelines for electrocardiogram (ECG) interpretation in athletes are associated with a relatively high false positive rate and warrant modification to improve the specificity without compromising sensitivity. aim this study was investigate whether non-specific anomalies such as axis deviation atrial enlargement isolation require further assessment highly trained young athletes. Between 2003 2011, 2533 aged 14–35 years were investigated 12-lead...
AimsPre-participation cardiovascular screening of young athletes may prevent sports-related sudden cardiac deaths. Recognition physiological electrocardiography (ECG) changes in healthy has improved the specificity while maintaining sensitivity for disease. The study objective was to determine clinical significance electrocardiographic right ventricular hypertrophy (RVH) athletes.
Objectives Aortic root dilatation is reported in young athletes; however, it unclear whether such remodelling physiological or, represents a potential aortopathy. This observational study investigated the prevalence and progression of aortic athletes competing at regional or national level. Methods Between 2003 2015, 3781 aged 19±5.9 years (63.3% male) underwent echocardiography as part cardiac screening programme to identify with structural abnormalities. Athletes trained for an average...
This study investigated the influence of African/Afro-Caribbean (black) ethnicity on clinical profile and outcomes in hypertrophic cardiomyopathy (HCM).425 consecutive patients with HCM (163 black 262 Caucasians (white); mean age 52.5±16.6 years) were assessed at three centres. Repeat assessments performed every 6-12 months follow-up was 4.3±3.0 years. The primary outcome a composite cardiovascular death, cardiac arrest or appropriate device therapy.A fortuitous diagnosis more commonly made...
Aim To investigate the accuracy of recently published international recommendations for ECG interpretation in young athletes a large cohort white and black adolescent soccer players. Methods 11 168 players (mean age 16.4±1.2 years) were evaluated with health questionnaire, echocardiogram; 10 581 (95%) male 163 (91%) white. ECGs retrospectively analysed according to (1) 2010 European Society Cardiology (ESC) recommendations, (2) Seattle criteria, (3) refined criteria (4) athletes. Results The...
To describe the genotype-phenotype relationship of a cohort consecutive patients with isolated ectopia lentis (EL) secondary to ADAMTSL4 and FBN1 mutations.Patients underwent detailed ocular, cardiovascular, skeletal examination. This was correlated Sanger sequencing genes.Seventeen were examined, including one et pupillae. Echocardiography examination revealed no sign systemic disorders associated EL, in particular Marfan syndrome (MFS). Nine (52.9%) found have mutations ADAMTSL4, four...