A5058036554- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Cardiovascular and exercise physiology
- Cardiac Arrest and Resuscitation
- Sports injuries and prevention
- Cardiovascular Issues in Pregnancy
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Myocardial Infarction Research
- Health Promotion and Cardiovascular Prevention
- Cardiovascular Disease and Adiposity
- Viral Infections and Immunology Research
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- Kawasaki Disease and Coronary Complications
- Climate Change and Health Impacts
- Potassium and Related Disorders
- Williams Syndrome Research
- Health Systems, Economic Evaluations, Quality of Life
- Pericarditis and Cardiac Tamponade
St George's, University of London
2017-2025
St George’s University Hospitals NHS Foundation Trust
2019-2025
Buckinghamshire Healthcare NHS Trust
2025
City St George's, University of London
2025
John Radcliffe Hospital
2023
Oxford University Hospitals NHS Trust
2023
Royal Berkshire Hospital
2016-2021
St. George's University
2018
Royal Berkshire NHS Foundation Trust
2016
University of Oxford
2014
Arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disorder characterized by myocardial fibrofatty replacement and increased risk of sudden cardiac death (SCD). Originally described as a right ventricular disease, ACM increasingly recognized biventricular entity. We evaluated pathological, genetic, clinical associations in large SCD cohort.We investigated 5205 consecutive cases referred to national pathology center between 1994 2018. Hearts tissue blocks were examined expert...
The feasibility and impact of high intensity exercise programmes in patients with hypertrophic cardiomyopathy (HCM) are unknown. This study was conducted to determine the a programme explore safety efficacy outcomes HCM. Participants were randomized 12-week supervised (n = 40) addition usual care, or care alone 40). All participants underwent assessment at baseline 12 weeks. group re-evaluated 6 months post-programme. Feasibility assessed by (i) recruitment, adherence, retention rates; (ii)...
Aim To investigate the accuracy of recently published international recommendations for ECG interpretation in young athletes a large cohort white and black adolescent soccer players. Methods 11 168 players (mean age 16.4±1.2 years) were evaluated with health questionnaire, echocardiogram; 10 581 (95%) male 163 (91%) white. ECGs retrospectively analysed according to (1) 2010 European Society Cardiology (ESC) recommendations, (2) Seattle criteria, (3) refined criteria (4) athletes. Results The...
Electrophysiological, imaging, and pathological studies have reported the presence of subtle structural abnormalities in hearts from patients with Brugada syndrome (BrS). However, data concerning disease involvement outside right ventricular outflow tract are limited. This study sought to characterize distribution myocardial fibrosis a cohort decedents experiencing sudden cardiac death caused by BrS. The authors evaluated 28 whole consecutive cases attributed BrS 29 comparator group...
Abstract Aims There is limited information on the clinical significance of complete right bundle branch block (CRBBB) in young individuals. The aim this study was to determine prevalence and CRBBB a large cohort individuals aged 14–35 years old. Methods results From 2008 2018, 104,369 consecutive underwent cardiovascular assessment with health questionnaire, electrocardiogram, consultation, selective echocardiography. Follow-up obtained via direct telephone consultations. Mean follow-up 7.3...
Background and aim The efficacy of pre-COVID-19 post-COVID-19 infection 12-lead ECGs for identifying athletes with myopericarditis has never been reported. We aimed to assess the prevalence significance de-novo ECG changes following COVID-19 infection. Methods In this multicentre observational study, between March 2020 May 2022, we evaluated consecutive Athletes exhibiting underwent cardiovascular magnetic resonance (CMR) scans. One club mandated CMR scans all players (n=30) infection,...
<h3>Background</h3> International recommendations for interpreting the athlete's ECG define a short PR interval as <120ms. Despite recommendation that asymptomatic athletes do not require further investigation unless an accessory pathway is suspected, are infrequently referred evaluation. The prevalence of in has previously been reported. <h3>Purpose</h3> To investigate young and its association with age, gender ethnicity. <h3>Methods</h3> Between 2011–2014, 15,572 aged 14–35 underwent...
<h3>Background</h3> The juvenile ECG pattern is defined as T wave inversion (TWI) in 2 contiguous anterior leads (V1 to V3) individuals<16 years of age. This due electrical predominance the right ventricle infancy which gradually resolves with normalisation waves post-puberty. Anterior TWI, however, also hallmark arrhythmogenic cardiomyopathy. recent international guidelines for electrocardiographic (ECG) interpretation athletes do not recommend further evaluation absence symptoms or...
Background: Outcome of Mitral Valve Prolapse (MVP) was controversial for long time. Many studies reported great differences in the incidence cardiovascular events due, above all, to heterogeneous and small studied populations. Most theme were also published late '80 last century till early '00. Purpose: To make a contemporary survey on selected population patients affected by primary MVP referred tertiary center medical surgical care valvular heart disease. Methods: We reviewed our database;...
Peripartum cardiomyopathy is a heart failure syndrome occurring late in pregnancy or during the early post-natal period. The pathophysiology of peripartum not fully understood and various mechanisms have been postulated including an underlying inflammatory process. We here report four cases presenting with acute left ventricular systolic dysfunction. Three out patients presented ejection fraction <30% one 35%. All made full clinical recovery following treatment high-dose intravenous...
Abstract Funding Acknowledgements Type of funding sources: Other. Main source(s): Cardiac Risk in the Young. Background Sudden cardiac death (SCD) seemingly affects young, healthy individuals and is therefore recognised as an important public health concern for athletes non-athletes. However, systematic population screening not recommended United Kingdom (UK). Concerns include low reported incidence SCD young individuals, efficacy electrocardiogram (ECG) lack robust evidence on screening. We...
Abstract Background Many individuals with hypertrophic cardiomyopathy (HCM) demonstrate exercise limitation. For a proportion this may be related to their overall cardiorespiratory fitness influenced by physical activity habits, body mechanics, or habitus. In others there is evidence of central and/or peripheral pathophysiology. However, some HCM favourable adaptation exercise. the SAFE-HCM study, participants who underwent 12 weeks high intensity showed significant improvement in indices...