Belinda Gray
A5080256028- Cardiac electrophysiology and arrhythmias
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Cardiac pacing and defibrillation studies
- Ion channel regulation and function
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- ECG Monitoring and Analysis
- Viral Infections and Immunology Research
- Genomics and Rare Diseases
- Autopsy Techniques and Outcomes
- Congenital Heart Disease Studies
- Cardiac Arrest and Resuscitation
- Cardiac Valve Diseases and Treatments
- Sports injuries and prevention
- Radiation Dose and Imaging
- Cardiac Imaging and Diagnostics
- Cardiac Health and Mental Health
- Forensic Entomology and Diptera Studies
- Genetics and Physical Performance
- Receptor Mechanisms and Signaling
- Vascular Procedures and Complications
- Interprofessional Education and Collaboration
- Acute Ischemic Stroke Management
- Williams Syndrome Research
Royal Prince Alfred Hospital
2015-2025
The University of Sydney
2016-2025
St George’s University Hospitals NHS Foundation Trust
2016-2025
St George's, University of London
2016-2025
City St George's, University of London
2025
Centenary Institute
2014-2024
Genomics (United Kingdom)
2024
Gold Coast Hospital
2022-2023
Royal North Shore Hospital
2022
National Health Service
2018-2020
The ESC Guidelines represent the views of and were produced after careful consideration scientific medical knowledge evidence available at time their publication.The is not responsible in event any contradiction, discrepancy and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies.Health professionals are encouraged take fully into account when exercising clinical...
Arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disorder characterized by myocardial fibrofatty replacement and increased risk of sudden cardiac death (SCD). Originally described as a right ventricular disease, ACM increasingly recognized biventricular entity. We evaluated pathological, genetic, clinical associations in large SCD cohort.We investigated 5205 consecutive cases referred to national pathology center between 1994 2018. Hearts tissue blocks were examined expert...
Importance Whether vigorous intensity exercise is associated with an increase in risk of ventricular arrhythmias individuals hypertrophic cardiomyopathy (HCM) unknown. Objective To determine whether engagement increased for and/or mortality HCM. The a priori hypothesis was that participants engaging activity were not more likely to have arrhythmic event or die than those who reported nonvigorous activity. Design, Setting, and Participants This investigator-initiated, prospective cohort...
The feasibility and impact of high intensity exercise programmes in patients with hypertrophic cardiomyopathy (HCM) are unknown. This study was conducted to determine the a programme explore safety efficacy outcomes HCM. Participants were randomized 12-week supervised (n = 40) addition usual care, or care alone 40). All participants underwent assessment at baseline 12 weeks. group re-evaluated 6 months post-programme. Feasibility assessed by (i) recruitment, adherence, retention rates; (ii)...
ALPK3 encodes the protein alpha-kinase 3, an essential cardiac-enriched atypical a-kinase that inserts in nuclear envelope and sarcomere M-band of cardiac myocytes, functioning to aid myosin-mediated force buffering proteostasis. Previously, bi-allelic loss-of-function variants have been reported causative a severe paediatric phenotype including hypertrophic (HCM) dilated cardiomyopathy (DCM). Very few heterozygous carries these cases express any phenotype. However, recently studies HCM. In...
Aim To investigate the accuracy of recently published international recommendations for ECG interpretation in young athletes a large cohort white and black adolescent soccer players. Methods 11 168 players (mean age 16.4±1.2 years) were evaluated with health questionnaire, echocardiogram; 10 581 (95%) male 163 (91%) white. ECGs retrospectively analysed according to (1) 2010 European Society Cardiology (ESC) recommendations, (2) Seattle criteria, (3) refined criteria (4) athletes. Results The...
Electrophysiological, imaging, and pathological studies have reported the presence of subtle structural abnormalities in hearts from patients with Brugada syndrome (BrS). However, data concerning disease involvement outside right ventricular outflow tract are limited. This study sought to characterize distribution myocardial fibrosis a cohort decedents experiencing sudden cardiac death caused by BrS. The authors evaluated 28 whole consecutive cases attributed BrS 29 comparator group...
Studies reporting on the incidence of sudden cardiac arrest and/or death (SCA/D) in athletes commonly lack methodological and rigor, which has implications for screening preventative policy sport. To date, there are no tools designed assessing study quality studies investigating SCA/D athletes.
BACKGROUND: Whether vigorous exercise increases risk of ventricular arrhythmias for individuals diagnosed and treated congenital long QT syndrome (LQTS) remains unknown. METHODS: The National Institutes Health–funded LIVE-LQTS study (Lifestyle Exercise in the Long Syndrome) prospectively enrolled 8 to 60 years age with phenotypic and/or genotypic LQTS from 37 sites 5 countries May 2015 February 2019. Participants (or parents) answered physical activity clinical events surveys every 6 months...
Sudden death in the young is a tragic complication of number medical diseases. There limited data regarding utility post-mortem Magnetic Resonance (MR) imaging and Computer Tomography (CT) scanning determining cause sudden death. This study sought to compare accuracy cross-sectional (MR CT) with conventional autopsy young. Consecutive patients from 2010 2012 (aged 1–35 years) who had were included. Patients scanned by CT 1.5 T MR prior being performed. The primary outcome was diagnostic...
Sports Cardiology practice commonly involves the evaluation of athletes for genetically determined cardiac conditions that may predispose to malignant arrhythmias, heart failure, and sudden death. High-level exercise can lead electrical structural remodelling which mimics inherited (ICCs). Differentiation between 'athlete's heart' pathology be challenging often requires whole armamentarium available investigations. Genetic studies over last 30 years have identified many genetic variants...