A5089282370- Lung Cancer Treatments and Mutations
- Cancer survivorship and care
- Schizophrenia research and treatment
- Cancer Risks and Factors
- Nutrition and Health in Aging
- Mental Health and Psychiatry
- Childhood Cancer Survivors' Quality of Life
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Mental Health Treatment and Access
- Cardiac pacing and defibrillation studies
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Effects of Exercise
- Sepsis Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Breast Cancer Treatment Studies
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Cardiac Arrhythmias and Treatments
- Substance Abuse Treatment and Outcomes
- Malaria Research and Control
- Breast Lesions and Carcinomas
- HIV Research and Treatment
- Mental Health Research Topics
Yale University
2015-2024
University of Ferrara
2022-2024
Yale Cancer Center
2013-2023
Yale New Haven Health System
2018-2023
Elmhurst Hospital Center
2023
Our Lady of Fatima Hospital
2023
Providence College
2023
University of Hawaiʻi at Mānoa
2023
University of Hawaii System
2023
Zhejiang University of Technology
2023
Routine resection of cavity shave margins (additional tissue circumferentially around the left by partial mastectomy) may reduce rates positive (margins for tumor) and reexcision among patients undergoing mastectomy breast cancer.In this randomized, controlled trial, we assigned, in a 1:1 ratio, 235 with cancer stage 0 to III who were mastectomy, or without selective margins, have further resected (shave group) not (no-shave group). Randomization occurred intraoperatively after surgeons had...
Arthralgia occurs in up to 50% of breast cancer survivors treated with aromatase inhibitors (AIs) and is the most common reason for poor AI adherence. We conducted, 121 receiving an reporting arthralgia, a yearlong randomized trial impact exercise versus usual care on arthralgia severity.Eligibility criteria included at least 6 months, ≥ 3 10 worst joint pain Brief Pain Inventory (BPI), < 90 minutes per week aerobic no strength training. Participants were randomly assigned (150 supervised...
The risks of sports participation for implantable cardioverter-defibrillator (ICD) patients are unknown.Athletes with ICDs (age, 10-60 years) participating in organized (n=328) or high-risk (n=44) were recruited. Sports-related and clinical data obtained by phone interview medical records. Follow-up occurred every 6 months. ICD shock outcomes adjudicated 2 electrophysiologists. Median age was 33 years (89 subjects <20 age); 33% female. Sixty competitive athletes (varsity/junior...
psychiatric condition.The finding is similar to previous findings: individuals with concurrent and medical diagnoses had poorer outcomes higher mortality. 4,5 unclear why illness predisposes COVID-19-related mortality.Psychiatric symptoms may arise as a marker of systemic pathophysiologic processes, such inflammation, that may, in turn, predispose mortality.Similarly, disorders augment inflammation compromise the function immune system, while psychotropic medications also be associated...
Importance Whether vigorous intensity exercise is associated with an increase in risk of ventricular arrhythmias individuals hypertrophic cardiomyopathy (HCM) unknown. Objective To determine whether engagement increased for and/or mortality HCM. The a priori hypothesis was that participants engaging activity were not more likely to have arrhythmic event or die than those who reported nonvigorous activity. Design, Setting, and Participants This investigator-initiated, prospective cohort...
Successful completion of chemotherapy is critical to improve breast cancer outcomes. Relative dose intensity (RDI), defined as the ratio delivered prescribed, a measure and associated with mortality. The effect exercise eating healthy diet on RDI unknown. We conducted randomized trial an nutrition intervention pathologic complete response (pCR) in women diagnosed initiating chemotherapy.
Obesity is associated with a higher risk of breast cancer mortality. The gold standard approach to weight loss in-person counseling, but telephone counseling may be more feasible. We examined the effect versus usual care on 6-month changes in body composition, physical activity, diet, and serum biomarkers.One hundred survivors mass index ≥ 25 kg/m(2) were randomly assigned (n = 33), 34), or (UC) 33). In-person included 11 30-minute sessions over 6 months. These focused reducing caloric...
To evaluate the amount of hemophagocytosis in 64 marrow core biopsy specimens and aspirates from 58 patients with clinical suspicion for secondary hemophagocytic lymphohistiocytosis (HLH) or reported findings hemophagocytosis.A review medical records assigned to a low-risk (45 patients) high-risk (13 HLH group, association histologic was examined using Fisher exact test.The aspirate specimen did not correlate disease probability (P = .17 P .63, respectively). Of clinical/laboratory criteria...
OBJECTIVE The childhood obesity epidemic has been accompanied by an increasing prevalence of type 2 diabetes (T2D), particularly in minority children. Twenty to thirty percent obese youth have “prediabetes,” a precursor marked insulin resistance, β-cell dysfunction, and impaired glucose tolerance. Diabetes Prevention Program demonstrated that T2D could be prevented/delayed intensive lifestyle modification adults with prediabetes, but efficacy similar interventions not established. Therefore,...
BACKGROUND Physical activity (PA) has been linked to a lower risk of developing and dying cancer, yet many cancer survivors do not exercise. In the current study, authors evaluated impact LIVESTRONG at YMCA exercise program, available Young Men's Christian Associations (YMCAs) across United States, on PA, fitness, quality life, fatigue, body composition, serum biomarkers, program safety in survivors. METHODS Cancer were recruited through Yale Center Dana‐Farber Institute randomized 12‐week,...
Objective This study examined the effect of 12 months aerobic and resistance exercise versus usual care on changes in body composition postmenopausal breast cancer survivors taking aromatase inhibitors (AIs). Methods The Hormones Physical Exercise enrolled 121 randomized them to either supervised twice‐weekly training 150 min/wk ( N = 61) or a 60) group. Dual‐energy X‐ray absorptiometry scans were conducted at baseline, 6 months, assess mass index, percent fat, lean mass, bone mineral...
Abstract Objective To describe the association between mistreatment, burnout, and having multiple marginalized identities during undergraduate medical education. Design Cross sectional survey retrospective cohort study. Setting 140 US schools accredited by Association of American Medical Colleges. Participants 30 651 graduating students in 2016 2017. Main outcome measures Self-reported sex, race or ethnicity, sexual orientation groups were considered, based on unique combinations...
Background This study examined the relationship between Duration of Untreated Psychosis (DUP) and functional outcomes at baseline, 6 months, 12 months after admission to Coordinated Specialty Care (CSC). Methods A total 246 participants from two U.S. public-sector CSC programs were categorized into Low High DUP groups using criteria: (i) a median split distribution (ii) World Health Organization (WHO) aspirational standard 3 months. Changes in global functioning (GAF), social (GF: Social),...
Early intervention services for psychotic disorders optimally interlock strategies to deliver: (i) Detection (ED) shorten the time between onset of symptoms and effective treatment (i.e. Duration Untreated Psychosis, DUP); (ii) comprehensive during subsequent 2 5 years. In latter category, are teams (‘First-episode Services’ or FES) that integrate several empirically supported treatments adapt their delivery younger patients caregivers. There is an urgent need hasten access established FES...
Traditional risk factors for type 2 diabetes mellitus are weak predictors of changes in glucose tolerance and insulin sensitivity youth.To identify early metabolic features resistance (IR) youth whether they predict deterioration glycemic control.A cross-sectional longitudinal study was conducted at the Yale Pediatric Obesity Clinic.Concentrations α-hydroxybutyrate, β-hydroxybutyrate, lactate, branched-chain amino acids (BCAAs) were measured by nuclear magnetic resonance spectroscopy 78...
Ovarian cancer survivors experience a wide range of treatment side effects that can negatively affect health-related quality life (HRQOL). Physical activity has been shown to improve HRQOL and cancer-related fatigue (CRF) for other survivors; however, no large randomized controlled trial (RCT) conducted ovarian cancer. This study examined the impact six-month RCT exercise vs attention control on change in (Short Form Health Survey-36) CRF (Functional Assessment Cancer Therapy-Fatigue Scale)...
Background The objective of this study was to evaluate the role a 12‐month exercise intervention on endocrine‐related quality life (QOL) and overall QOL among breast cancer survivors with aromatase inhibitor (AI)‐induced arthralgia in Hormones Physical Exercise (HOPE) Study. Methods This randomized controlled trial 121 who were currently receiving AIs experiencing at least mild arthralgia. assessed using Functional Assessment Cancer Therapy (FACT) questionnaires 36‐Item Short Form Survey...
Duration of Untreated Psychosis (DUP) remains unacceptably long and limits effectiveness care. To determine whether an early detection campaign ("Mindmap") can reduce DUP in a US community setting.
Abstract Background Lung cancer survivors need more options to improve quality of life (QoL). It is unclear what extent patients with advanced stage disease are willing participate in home-based physical activity (PA) and if these interventions QoL. The goal our study was determine interest participating 3-month walking regimen lung cancer. We used a randomized design evaluate for potential benefit PA patient-reported outcomes. Methods performed an open-label, 1:1 trial 40 III/IV non-small...