A5086547393- Cardiovascular and exercise physiology
- Physical Activity and Health
- Heart Rate Variability and Autonomic Control
- Obesity, Physical Activity, Diet
- Cardiovascular Effects of Exercise
- Cardiovascular Health and Disease Prevention
- Genetic Associations and Epidemiology
- School Health and Nursing Education
- Heart rate and cardiovascular health
- Cardiovascular Disease and Adiposity
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nutrition and Health in Aging
- Children's Physical and Motor Development
- Sports Performance and Training
- Sports injuries and prevention
- Diet and metabolism studies
- Cerebrovascular and Carotid Artery Diseases
- Cardiac electrophysiology and arrhythmias
- Health and Wellbeing Research
- Eating Disorders and Behaviors
- Cardiovascular Health and Risk Factors
University of Eastern Finland
2016-2025
Kuopio University Hospital
2015-2024
Karolinska Institutet
2015
Finland University
2015
Kuopion Liikuntalääketieteen Tutkimuslaitos
2015
Pennington Biomedical Research Center
2003
STMicroelectronics (France)
1999
The ESC Guidelines represent the views of and were produced after careful consideration scientific medical knowledge evidence available at time their publication.The is not responsible in event any contradiction, discrepancy and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies.Health professionals are encouraged take fully into account when exercising clinical...
The mechanisms by which exercise benefits patients with non-alcoholic fatty liver disease (NAFLD), the most common worldwide, remain poorly understood. A non-targeted liquid chromatography-mass spectrometry (LC-MS)-based metabolomics analysis was used to identify metabolic changes associated NAFLD in humans upon intervention (without diet change) across four different sample types-adipose tissue (AT), plasma, urine, and stool. Altogether, 46 subjects participated this randomized controlled...
Aims The objective is to study whether a heart rate (HR) response during exercise test independently predicts cardiovascular disease (CVD) mortality.
Division by total body weight is the usual way to standardise peak oxygen uptake (peak VO2) for size. However, this method systematically underestimates cardiopulmonary fitness in obese individuals. Our aim was analyse whether lean-mass a better base mass-independent standard of fitness. A population based sample 578 men (body mass index (BMI) 19–47 kg/m2) and 592 women (BMI 16–49 57–78 years age. Peak VO2 assessed respiratory gas analysis during maximal exercise test on cycle ergometer. We...
Longitudinal studies demonstrate an average decline in physical activity (PA) from adolescence to young adulthood. However, while some subgroups of adolescents decrease activity, others increase or maintain high low activity. Activity domains may differ between (exhibiting different PA patterns), and they offer valuable information for targeted health promotion. Hence, the aim this study was identify patterns adulthood; also explore associations (i) changes sedentary time, (ii)...
Effects of cycling alone or in a sheltered position on subsequent running performance during triathlon. Med. Sci. Sports Exerc., Vol. 31, No. 4, pp. 599-604, 1999. Purpose: The purpose this study was to compare the responses triathlon which performed alone, as well drafting position. Methods: Eight male triathletes international level sprint-distance (0.75-km swim, 20-km bike, 5-km run) two different occasions, one completely (TA), other drafter bike leg event (TD). speed drafted remained at...
Summary Background Measurement of heart rate variability (HRV) is a useful method for examining cardiac autonomic control. HRV has been measured in many studies among adults, but research on this topic children limited. We therefore defined reference values large number parameters children. Methods The subjects were population sample 465 mainly prepubertal 6–8 years age. Electrocardiogram (ECG) was recorded at rest, and 1‐ 5‐min ECG samples selected analyses. data analysed boys girls...
Background:Previous studies have found positive associations between cardiorespiratory fitness (CRF) and cognitive performance in older people but data are inconsistent methodological limitations. Objective:Our aim was to study the longitudinal of CRF with executive functions, processing speed memory as well overall function at risk for impairment. Methods:Participants (n = 421), mean age 69.0, were a sub-sample The Finnish Geriatric Intervention Study Prevent Cognitive Impairment Disability...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is one of the key regulators low-density lipoprotein cholesterol plasma levels. Circulating PCSK9, which differs between genders, represents a valid pharmacological target for preventing cardiovascular (CV) events. We aimed to investigate sex-related associations PCSK9 levels and biochemical anthropomorphic factors, familial personal morbidities, in large European cohort (n = 3673) men (47.9%) women (52.1%).Individuals (aged 54-79 years)...
Evidence for the effects of exercise and dietary interventions on cognition from long-term randomized controlled trials (RCTs) in large general populations remains insufficient. The objective our study was to investigate independent combined resistance aerobic a population sample middle-aged older individuals. We conducted 4-y RCT 1401 men women aged 57–78 y at baseline. participants were randomly assigned exercise, diet, or control group. Exercise goals least moderate-intensity ≥2 times/wk...
Background : Studies measuring physical activity (PA) and sedentary behavior on a 24/7 basis are scarce. The present study assessed the feasibility of using an accelerometer at hip while awake wrist sleeping to describe patterns in working-aged adults by age, sex, fitness. Methods was based FinFit 2017 where 20- 69-year-old Finns triaxial (UKKRM42; UKK Terveyspalvelut Oy, Tampere, Finland). During waking hours, kept right and, during time bed, nondominant wrist. PA variables were 1-min...
We studied the associations of cardiorespiratory fitness with metabolic syndrome in older men and women, because such data are limited representative population samples.We a sample 671 676 women aged 57-79 years at baseline randomized controlled intervention study. assessed maximal oxygen uptake (Vo(2max)) by respiratory gas analysis during bicycle exercise test.Vo(2max) had strong, inverse, graded association risk having as defined National Cholesterol Education Program criteria. Men lowest...
The objective is to study whether a heart rate (HR) increase from 40 100% of maximal work capacity in the exercise test (HR40-100) independently predicts mortality men with known or suspected coronary disease (CHD).The subjects were 294 men, 42-61 years age, eastern Finland CHD but without use HR-lowering medication at baseline. HR was measured rest and during maximal, symptom-limited test. During an average follow-up 11.0 years, there 61 all-cause deaths. In Cox-multivariable model,...
Carotid intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. To date, large-scale investigations genetic determinants cIMT are sparse.
Summary Background In the exercise testing measures of cardiorespiratory fitness need to be scaled by body size or composition enable comparison between individuals. Traditionally used weight‐proportional are potentially confounded adiposity that hampers their interpretation and applicability in clinical assessment fitness. Objective We aimed find most appropriate measure for scaling among children. Methods assessed weight height, maximal workload ( W MAX ) oxygen uptake VO 2 using cycle...
The rapid increase in the prevalence of dementia associated with ageing populations has stimulated interest identifying modifiable lifestyle factors that could prevent cognitive impairment. One such potential preventive factor is Nordic diet been shown to reduce risk CVD; however, its effect on cognition not studied. aim present study was estimate cross-sectional and longitudinal associations baseline function at after a 4-year follow-up population-based random sample ( n 1140 women men, age...
Sports clubs form a potential setting for health promotion, but the research is limited. The aim of Health Promoting Club (HPSC) study was to elucidate current promotion activities youth sports and coaches, investigate behaviours status participating in compared non-participants.The design employs cross-sectional multilevel multimethod with aspirations prospective cohort next phase. setting-based variables at coaching levels, behaviour individual level, are investigated using surveys; total...
Abstract Aims/hypothesis We studied for the first time long-term effects of a combined physical activity and dietary intervention on insulin resistance fasting plasma glucose in general population predominantly normal-weight children. Methods carried out 2 year non-randomised controlled trial sample 504 children aged 6–9 years at baseline. The were allocated to group (306 baseline, 261 2-year follow-up) or control (198 children, 177 children) without blinding. measured glucose, calculated...