A5048679570- Cardiovascular Effects of Exercise
- Cardiovascular and exercise physiology
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Heart Rate Variability and Autonomic Control
- Physical Activity and Health
- Sports injuries and prevention
- Cardiac Fibrosis and Remodeling
- Economic Growth and Development
- Cardiovascular Health and Risk Factors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genetics and Physical Performance
- Fiscal Policy and Economic Growth
- Obesity, Physical Activity, Diet
- Cardiac Health and Mental Health
- Service-Learning and Community Engagement
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Cardiac Structural Anomalies and Repair
- Cardiac electrophysiology and arrhythmias
- Heart Failure Treatment and Management
- Renal and related cancers
- Business Law and Ethics
- Respiratory Support and Mechanisms
Massachusetts General Hospital
2016-2025
Broad Institute
2021-2025
Brigham and Women's Hospital
2021-2025
Harvard University
2009-2025
Northwestern Memorial Hospital
2025
Mass General Brigham
2024
Middlebury College
2023
Beth Israel Deaconess Hospital
2021
Beth Israel Deaconess Medical Center
2021
Hadassah Medical Center
2021
The airways are conduits that transport atmospheric oxygen to the distal alveolus. Normally, airway mucous cells rare. However, diseases of often characterized by metaplasia, in which there dramatic increases cell numbers. As Notch pathway is known regulate fate many contexts, we misexpressed active intracellular domain mouse Notch1 receptor lung epithelium. misexpression resulted an increase and a decrease ciliated airway. Similarly, embryonic tracheal explants adult human epithelium...
Importance Guidelines recommend 150 minutes or more of moderate to vigorous physical activity (MVPA) per week for overall health benefit, but the relative effects concentrated vs evenly distributed are unclear. Objective To examine associations between an accelerometer-derived “weekend warrior” pattern (ie, most MVPA achieved over 1-2 days) spread with risk incident cardiovascular events. Design, Setting, and Participants Retrospective analysis UK Biobank cohort study participants providing...
The rapid emergence and exploding usage of online social networking forums, which are frequented by millions, present clinicians with new ethical professional challenges. Particularly among a younger generation physicians patients, the use forums has become widespread. In this article, we discuss challenges facing patient-doctor relationship as result growing forums. We draw upon one heavily used highly trafficked forum, Facebook, to illustrate elements these environments peculiar their...
The effects of Wnt7b on lung development were examined using a conditional Wnt7b-null mouse. lungs are markedly hypoplastic, yet display largely normal patterning and cell differentiation. In contrast to findings in prior hypomorphic models, we find decreased replication both developing epithelium mesenchyme, without abnormalities vascular smooth muscle development. We further demonstrate that signals neighboring cells activate autocrine paracrine canonical Wnt signaling cascades. results...
Objectives Persistent or late-onset cardiopulmonary symptoms following COVID-19 may occur in athletes despite a benign initial course. We examined the yield of cardiac evaluation, including exercise testing (CPET), with after COVID-19, compared CPETs these and those without evaluated longitudinal changes CPET improvement symptoms. Methods This prospective cohort study young (18–35 years old) referred for that were present>28 days from diagnosis. findings post-COVID matched reference group...
BACKGROUND: Achievement of guideline-recommended levels physical activity (≥150 minutes moderate-to-vigorous per week) is associated with lower risk adverse cardiovascular events and represents an important public health priority. Although commonly follows a “weekend warrior” pattern, in which most concentrated 1 or 2 days rather than spread more evenly across the week (regular), effects pattern range incident diseases, including cardiometabolic conditions, are unknown. METHODS: We tested...
<h3>Importance</h3> Aortic dilatation is frequently encountered in clinical practice among aging endurance athletes, but the distribution of aortic sizes this population unknown. It additionally uncertain whether may represent adaptation to long-term exercise, similar well-established process ventricular remodeling. <h3>Objective</h3> To assess prevalence masters-level male and female athletes with about 2 decades exercise exposure. <h3>Design, Setting, Participants</h3> This cross-sectional...
To gain insights into the mechanisms driving cardiovascular complications in COVID-19, we performed a case-control plasma proteomics study COVID-19 patients. Our results identify senescence-associated secretory phenotype, marker of biological aging, as dominant process associated with disease severity and cardiac involvement. FSTL3, an indicator senescence-promoting Activin/TGFβ signaling, ADAMTS13, von Willebrand Factor–cleaving protease whose loss-of-function causes microvascular...
Abstract Cardiac ageing is an intricate and multifaceted process with considerable impact on public health, especially given the global demographic shift towards aged populations. This review discusses structural, cellular, functional changes associated cardiac heart failure preserved ejection fraction (HFpEF). Key molecular mediators are considered within framework of established hallmarks ageing, particular attention to promising therapeutic candidates. We further delineate differential...
To characterize the impact of obesity on disease severity in patients with coronavirus 2019.This was a retrospective cohort study designed to evaluate association between body mass index and risk severe 2019. Data were abstracted from electronic health record. The primary endpoint composite intubation or death.Two hospitals Massachusetts (one quaternary referral center one affiliated community hospital).Consecutive hospitalized confirmed 2019 admitted March 13, 2020, April 3, 2020.None.A...
Abstract Systemic inflammation has been implicated in the pathobiology of heart failure with preserved ejection fraction (HFpEF). Here, we examine association upstream mediators as ascertained by fatty-acid derived eicosanoid and eicosanoid-related metabolites HFpEF status exercise manifestations HFpEF. Among 510 participants chronic dyspnea LVEF who underwent invasive cardiopulmonary testing, find that 70 890 related are associated status, including 17 named 53 putative eicosanoids (FDR q...
Abstract A full description of the ontogeny β cell would guide efforts to generate cells from embryonic stem (ESCs). The first step requires an understanding definitive endoderm: genes and signals responsible for its specification, proliferation, patterning. This report describes a global marker endoderm, Claudin‐6 (Cldn6). We expression in early development with particular attention endoderm derivatives. To create genetic system drive gene throughout both spatial temporal control, we target...
Accurate interpretation of cardiopulmonary exercise testing (CPET) relies on age, gender, and modality-specific reference values. To date, clinically applicable CPET values derived from a source population endurance athletes (EAs) have been lacking. The purpose this study was to generate for use in the clinical assessment EA.Prospective data accrued during care healthy EA were used derive develop novel equations V˙O2peak. performance these compared contemporary standard assessed discrete...