A5054926842- Diet and metabolism studies
- Pharmacology and Obesity Treatment
- COVID-19 Clinical Research Studies
- Heavy Metals in Plants
- Neuroendocrine Tumor Research Advances
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Genomics, phytochemicals, and oxidative stress
- Genetics, Bioinformatics, and Biomedical Research
- Atherosclerosis and Cardiovascular Diseases
- Heavy Metal Exposure and Toxicity
- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular Function and Risk Factors
- Computational Drug Discovery Methods
- Pituitary Gland Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Heavy metals in environment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neurological disorders and treatments
- Respiratory and Cough-Related Research
- Social Media in Health Education
- Coal and Coke Industries Research
- Medicinal Plants and Neuroprotection
- Ion Channels and Receptors
- Ectopic Pregnancy Diagnosis and Management
SRM Institute of Science and Technology
2025
Massachusetts General Hospital
2022-2025
University of Engineering & Management
2020-2024
Harvard University
2021-2023
Burke Medical Research Institute
2019-2023
University of Utah
2020-2022
Chelsea Hospital
2022
St. Barnabas Hospital
2021
Montefiore Medical Center
2021
East Valley Hematology & Oncology
2021
To gain insights into the mechanisms driving cardiovascular complications in COVID-19, we performed a case-control plasma proteomics study COVID-19 patients. Our results identify senescence-associated secretory phenotype, marker of biological aging, as dominant process associated with disease severity and cardiac involvement. FSTL3, an indicator senescence-promoting Activin/TGFβ signaling, ADAMTS13, von Willebrand Factor–cleaving protease whose loss-of-function causes microvascular...
Apoptosis is an active response of cells to altered microenvironments, which characterized by cell shrinkage, chromatin condensation, and DNA fragmentation, in a variety types such as renal epithelial cells, endothelial mesangial podocytes. Hyperglycemia among the microenvironmental factors that may facilitate apoptosis, plays decisive role initiation diabetic nephropathy. Transforming growth factor-β emerges powerful fibrogenic factor development hypertrophy. Although, number potential...
CD36 expressed in multiple cell types regulates inflammation, vascular function, and innate immunity. Specifically, microvascular endothelial cells (ECs) signals to elicit inflammation causes EC death. This study investigated roles for EC-CD36 on acute stroke pathology normal obese conditions. Obesity induced by a high-fat diet (HD) selectively increased expression ECs, not monocytes/macrophages, the post-ischemic brain. Mice deficient ECs (EC CD36−/− ) showed reduced injury size...
Background . Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is the major receptor for (Ox-LDL) in aorta of aged rats. Ox-LDL initiates LOX-1 activation endothelium lipid-accumulating sites both animal and human subjects hypercholesterolemia. Targeting may provide a novel diagnostic strategy towards hypercholesterolemia vascular diseases. Hypothesis This study was planned to address whether aegeline (AG) could bind with higher affinity modulate uptake Study Design Thirty-six...
Background: Aegeline (AG) is a natural hydroxyamide which has not been explored in depth for its potential applications food, pharmaceutical, and cosmetic industries. Accordingly, this study, the property of AG as antioxidant, anti-hypercholesterolemic, an anti-aging component was explored. The hepatoprotective effect on hypercholesterolemic rats investigated health care benefits hypocholesterolemic drug vs Atorvastatin (AV) first time.Objective: objective to delineate mechanism action...
Cardiac hypertrophy is the underlying cause of heart failure and characterized by excessive oxidative stress leading to collagen deposition. Therefore, understanding signalling mechanisms involved in extracellular matrix deposition necessary prevent cardiac remodelling failure. In this study, we hypothesized that hesperetin, a flavanone elicits activation Nrf2 thereby suppresses stress, mediated pathological progression. A model was established with subcutaneous injection isoproterenol male...
Motivation: Developing a de facto method to generate synthetic protein sequences is challenging task that ensures confidence in engineering, provides functional insights, and aids target identification. We highlight the sequence design, focusing on optimizing their validity by encouraging immense potential various domains. Methods: In this framework, first we create Ramachandran plot, which has been designed identify conformational region space for protein. Then, model tailored proteins...
Cardiac complications, including myocardial injury and dysfunction, are common in severe viral respiratory infections (VRI) associated with increased mortality 1-3 . The pathophysiology of VRI-induced is multifactorial, but frequently involves structural damage to the heart's microvascular network that leads subsequent ischemia dysfunction 4-6 Currently, there no targeted therapies available prevent or attenuate VRI-associated injury. Moreover, molecular mechanisms driving cardiac pathology...
This study investigates the factors influencing rising adoption of cardless ATM cash withdrawals in Nepal, focusing on perceived ease use, customer trust, usefulness, security, and amount information. Using a mixed-method approach with 107 respondents, data were analyzed via SPSS, revealing that security information significantly drive demand, while traditional like use trust showed weaker impacts. These insights challenge conventional assumptions offer actionable strategies for financial...
The aim of this study was to evaluate and compare the effect chlorhexidine (CHX) chip turmeric as a local drug delivery (LDD) agent in treatment patients with chronic periodontitis.A total 120 sites pocket depths 5-8 mm were chosen split mouth design at 3 same patient. Selected randomly divided into three groups receive CHX addition scaling root planing (SRP) group A, SRP B, only C. Clinical parameters, that is, plaque index (PI), gingival (GI), probing depth (PPD), relative attachment level...
The Mahatma Gandhi National Rural Employment Guarantee Act (MGNREGA) of 2005 guarantees adult members rural households to a minimum 100 days employment with certain provisions geared specifically towards women. phase wise rollout the program allows us employ difference-in-differences strategy examine effects on children's education. Using two phases District Level Household and Facility Survey, we find no significant impact Although our results are not significant, consistent negative...
Parkinson's disease is a progressive neurodegenerative movement disorder with the cardinal symptoms of bradykinesia, resting tremor, rigidity, and postural instability, which lead to abnormal movements lack activity, in turn cause muscular damage. Even though studies have been carried out elucidate causative factors that damage disease, apoptotic events occur skeletal muscle therapeutical approach culminate not extensively studied. Thus, this study evaluates impact rotenone-induced SNPc...
Background: The intestinal microbe-derived metabolite trimethylamine N-oxide (TMAO) is known to the increase risk of cardiovascular diseases (CVDs). Endothelial dysfunction associated with most forms CVDs and characterized by damage endoplasmic reticulum (ER). current study was aimed investigate involvement stress (ERS)-mediated protein kinase R-like (PERK) signaling in TMAO induced endothelial dysfunction. Methods Results: Biochemical analysis showed that PERK, CHOP, IRE-1α, AFT-4, eIF2 α...
Introduction: Exercise training (ExT) improves functional capacity in older adults with heart failure (HF). However, the molecular mechanisms by which ExT exerts these benefits are unclear. We previously showed that cardiac activin type II receptor (ActRII) signaling increases aging and HF, ActRII inhibition can improve exercise aged C57BL/6 mice, a model of age-related HFpEF. Whether is modulated unknown. Hypothesis: hypothesized would attenuate mice. Methods: A moderate intensity protocol...