A5036169668- Lymphatic System and Diseases
- Cancer Immunotherapy and Biomarkers
- Cancer, Stress, Anesthesia, and Immune Response
- Sympathectomy and Hyperhidrosis Treatments
- Myofascial pain diagnosis and treatment
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Effects of Exercise
- Immune cells in cancer
- Pain Mechanisms and Treatments
- Planarian Biology and Electrostimulation
- Lymphatic Disorders and Treatments
- Tendon Structure and Treatment
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Tea Polyphenols and Effects
- Immune Response and Inflammation
- Psoriasis: Treatment and Pathogenesis
- Pharmacological Effects of Natural Compounds
- Vitamin K Research Studies
- Cardiac Fibrosis and Remodeling
- Vitamin C and Antioxidants Research
- Dermatological and Skeletal Disorders
- Inflammatory Biomarkers in Disease Prognosis
- PI3K/AKT/mTOR signaling in cancer
- Cardiac Ischemia and Reperfusion
Harvard University
2021-2025
Massachusetts General Hospital
2021-2025
Sungkyunkwan University
2015-2020
Soonchunhyang University
2016
Hallym University Sacred Heart Hospital
2016
National Cancer Center
2016
National Cancer Center
2016
Konyang University
2003
An adjuvant composed of saponin and a TLR4 agonist acts by enhancing lymph flow antigen entry into nodes.
Abstract The mechanisms behind the antitumor effects of exercise training (ExTr) are not fully understood. Using mouse models established breast cancer, we examined here causal role CD8+ T cells in benefit acquired from ExTr tumor control, as well ability to improve immunotherapy responses. We implanted E0771, EMT6, MMTV-PyMT, and MCa-M3C cancer orthotopically wild-type or Cxcr3−/− female mice initiated intensity-controlled sessions when tumors reached approximately 100 mm3. characterized...
L-Ascorbic acid (vitamin C, AA) exhibits anti-cancer effects with high-dose treatment through the generation of reactive oxygen species (ROS) and selective damage to cancer cells. The L-ascorbic are determined by sodium-dependent vitamin C transporter 2 (SVCT-2), a acid. In this study, we demonstrate that showed efficient activity in cell lines high expression levels SVCT-2 for gradient concentration from 10 μM -2 mM. However, low expressing lines, (>1 mM) but low-dose (<10 μM) induced...
Oxaliplatin is a platinum-based anticancer drug used to treat metastatic colorectal, breast, and lung cancers. While oxaliplatin kills cancer cells effectively, it exhibits several side effects of varying severity. Neuropathic pain commonly experienced during treatment with oxaliplatin. Patients describe symptoms paresthesias or dysesthesias that are triggered by cold (acute neuropathy), as abnormal sensory motor function (chronic neuropathy). In particular, we found aluminum levels were...
ABSTRACT The lymphatic vasculature plays essential roles in fluid balance, immunity, and lipid transport. Chronic, low‐grade inflammation peripheral tissues develops when structure or function is impaired, as observed during aging. While aging has been associated with a broad range of heart pathophysiology, its effect on cardiac not characterized. Here, we analyzed lymphatics aged 20‐month‐old mice versus young 2‐month‐old mice. Aged hearts showed reduced vascular density, more dilated...
The gut microbiome plays an important role in the protection against various systemic diseases. Its metabolic products profoundly influence a wide range of pathophysiological events, including regulation bone health. This review discusses recently established connections between and metabolism, focusing on impact microbiome-derived metabolites such as SCFAs, Bile Acids, tryptophan to control remodeling immunoreactions. Recent advances metagenomics profiling have unveiled new exciting...
Cardiac complications, including myocardial injury and dysfunction, are common in severe viral respiratory infections (VRI) associated with increased mortality 1-3 . The pathophysiology of VRI-induced is multifactorial, but frequently involves structural damage to the heart's microvascular network that leads subsequent ischemia dysfunction 4-6 Currently, there no targeted therapies available prevent or attenuate VRI-associated injury. Moreover, molecular mechanisms driving cardiac pathology...
To clarify the diabetic complications mediated by increased platelet activity, we undertook a study of mean component (MPC), as determined an automated hematologic analyzer (ADVIA 120, Bayer). Prothrombin time (PT), activated partial thromboplastin (aPTT), and fibrinogen were also measured to investigate blood viscosity abnormalities. MPC was in 100 healthy controls patients, latter which subdivided into no retinopathy (DR) (n = 25), nonproliferative DR 30), proliferative 45) groups. The...
Abstract Although surgery and radiation are beneficial for treating cancer, they can also lead to malfunctions of the lymphatic system such as secondary lymphedema. This abnormality is characterized by severe swelling, adipogenesis, inflammation, fibrosis in lymphedematous region. Moreover, proliferation fibrotic tissue region generates edema that no longer spontaneously reversible. No treatment has been validated patients with In our efforts develop a therapeutic agent lymphedema fibrosis,...
Acquired lymphedema is one of the most dreaded side effects cancer treatment, such as surgical treatment or irradiation. However, due to lack appropriate animal models, there no effective therapeutic method cure acquired lymphedema. To develop a reproducible model, we devised mouse hind limb model by removing superficial inguinal lymph node, popliteal deep and femoral lymphatic vessel. We measured volume lymphedematous leg observed change in level hyaluronic acid (HA) lymphangiogenic factors...
Abstract Lymphatic muscle cells (LMCs) within the wall of collecting lymphatic vessels exhibit tonic and autonomous phasic contractions, which drive active lymph transport to maintain tissue-fluid homeostasis support immune surveillance. Damage LMCs disrupts function is related various diseases. Despite their importance, knowledge transcriptional signatures in how they relate normal disease contexts largely missing. We have generated a comprehensive single-cell atlas—including LMCs—of mouse...
Tomato yellow leaf curl virus (TYLCV), one of the most serious plant viruses in tropical and subtropical regions, is transmitted to host plants by vector insect Bemisia tabaci. In order control TYLCV, it important identify weed hosts for overwintering TYLCV. Stellaria aquatica, a winter-hardy weed, was found growing with TYLCV-infected tomato greenhouse production. TYLCV detected S. aquatica polymerase chain reaction Southern blot hybridization analysis. The intergenic region nucleotide...
Purpose: To investigate the characteristics of lymphedema in patients treated with mammalian target rapamycin (mTOR) inhibitors and delineate complex decongestive therapy (CDT) outcomes. Methods Results: We retrospectively analyzed 24 mTOR inhibitor-induced 7 (control) not inhibitors, who visited clinic department rehabilitation medicine from March 2016 to December 2019. comprehensively reviewed clinical features, medication history, associated diseases, lymphoscintigraphy, lower extremity...
// Kun Kim 1, 2, * , Kyung-Hee Kangsan Roh 3, Byong Chul Yoo 1 Ja-Lok Ku 4 Young-Kyoung Shin 2 Jae Youl Cho 3 Minjae 5 Myung-Hee Kwon Sung Ho Goh 6 Hee Jin Chang 7 Hwan Oh Colorectal Cancer Branch, Research Institute, National Center, Goyang, Gyeonggi, Republic of Korea Seoul University College Medicine, Seoul, Department Genetic Engineering, Sungkyunkwan University, Suwon, Biomedical Sciences, Microbiology, Ajou School Genomics Center for Cancer, These authors contributed equally to this...
Preoperative chemoradiotherapy (CRT) is generally performed for locally advanced rectal cancer (LARC, cStage 2 or 3) to improve local disease control and patient survival. The pathological tumor response CRT a surrogate marker that associated with oncological outcome. Thus, markers predict the would be valuable individualizing treatment LARC patients. current study used metabolomics-based approaches identify molecular CRT. Seventy-six patients who received pelvic radiotherapy concurrent...
The lymphatic vascular system plays an important role in tissue fluid homeostasis. Lymphedema is a chronic, progressive, and incurable condition that leads to retention; it may be primary (heritable) or secondary (acquired) nature. Although there growing understanding of lymphedema, methods for the prevention treatment lymphedema are still limited. In this study, we investigated differential protein expressions sham‐operated lymphedema‐operated mice 3 days, using two‐dimensional gel...