A5015158338- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Chemical Synthesis and Analysis
- Cytokine Signaling Pathways and Interactions
- S100 Proteins and Annexins
- Synthesis and Catalytic Reactions
- Asymmetric Synthesis and Catalysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Adipose Tissue and Metabolism
- Catalytic C–H Functionalization Methods
- Adipokines, Inflammation, and Metabolic Diseases
- Endoplasmic Reticulum Stress and Disease
- Carbohydrate Chemistry and Synthesis
- Pancreatic function and diabetes
- Autophagy in Disease and Therapy
- Synthetic Organic Chemistry Methods
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Lymphatic System and Diseases
- Advanced Synthetic Organic Chemistry
- Microbial Natural Products and Biosynthesis
- Viral Infections and Immunology Research
- Free Radicals and Antioxidants
- Asymmetric Hydrogenation and Catalysis
- Lipid metabolism and biosynthesis
Bio-Medical Science (South Korea)
2017-2024
Gyeonggi Research Institute
2010-2017
Gyeonggi College of Science and Technology
2013-2017
Suwon Research Institute
2015
Institute of Science and Technology
2013-2015
University of California, Los Angeles
2011-2013
Kyung Hee University
2013
Seoul National University
2002-2010
Yeungnam University
2007
Molecules that induce ribosomal read-through of nonsense mutations in mRNA and allow production a full-length functional protein hold great therapeutic potential for the treatment many genetic disorders. Two such compounds, RTC13 RTC14, were recently identified by luciferase-independent high-throughput screening assay shown to have functions ATM dystrophin genes. We now tested ability RTC14 restore expression into skeletal muscles mdx mouse model Duchenne muscular dystrophy (DMD). Direct...
Silibinin is the major active molecule of silymarin, mixture flavonolignans extracted from Cirsium japonicum. It has been used for treatment hepatitis and inflammation-related diseases. In present study, effects silibinin on allergic inflammation its signaling were investigated in induced human mast cells.
Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations. Despite the promise this approach, only few read-through compounds (RTCs) have been discovered to date. These include aminoglycosides (e.g., gentamicin and G418) nonaminoglycosides PTC124 RTC13). The therapeutic benefits these RTCs remain determined. In an effort find new RTCs, we screened additional ~36,000 small molecular weight...
A facile synthesis of chiral α-alkyl serines 3 involves the asymmetric alkylation substrates 1 with alkyl halides (RX) under phase-transfer catalysis (PTC), followed by acidic hydrolysis products 2. The phenyl oxazoline moiety enhances acidity α proton ester and is an excellent protecting group for both amino hydroxy functions serine ester. Supporting information this article available on WWW http://www.wiley-vch.de/contents/jc_2002/2004/z53496_s.pdf or from author. Please note: publisher...
An enantioselective synthetic method for (−)-cis-clavicipitic acid (1) was reported. 1 obtained in 10 steps (99% ee and 20% overall yield) from 1H-indole-3-carboxylic methyl ester (9) via asymmetric phase-transfer catalytic alkylation diastereoselective Pd(II)-catalyzed intramolecular aminocyclization as key steps.
Abstract The rhodium(III)‐catalyzed cross‐coupling reaction between N ‐sulfonyl aldimines and various olefins such as maleimides, fumarates, maleates, α,β‐unsaturated ketones, acrylate nitroalkenes is described. This transformation efficiently leads to the diastereoselective synthesis of pharmacologically privileged 1‐aminoindane derivatives via C−H alkylation followed by subsequent intramolecular cyclization. Notably, single diastereomers in all cases were observed, relative stereochemistry...
Highly enantioselective synthesis of a potent metabotropic receptor ligand, (2S)-α-(hydroxymethyl)-glutamic acid (2, HMG) was accomplished by the catalytic Michael addition 2-naphthalen-1-yl-2-oxazoline-4-carboxylic tert-butyl ester (3b), using phosphazene base, BEMP, in CH2Cl2 at −60 °C presence (S)-binaphthyl quaternary ammonium salt 4.
The facile synthesis of hydroxymethylated indole derivatives is crucial for their further development as pharmaceutical compounds and other synthetic purposes. Herein, we describe the ruthenium(II)-catalyzed hydroxymethylation indolines N-heterocycles using paraformaldehyde an abundant C1 feedstock. A wide substrate scope range high levels site selectivity well functional group tolerance were observed.
Ruthenium(II)-catalyzed C(sp2)–H functionalization of N-aryl phthalazinones with a range aldehydes and activated ketone is described. Initial formation hydroxyalkylated subsequent Mitsunobu cyclization provided facile access to biologically relevant indazolophthalazinones. The utility this method highlighted by synthetic transformations into series potentially bioactive scaffolds.
The first enantioselective synthesis of (+)-hygrine (1) is reported. 1 was obtained in 12 steps with 29% overall yield and 97% ee via asymmetric phase-transfer catalytic alkylation ring-closing metathesis as key steps. absolute configuration could be directly confirmed R.
Abstract Stimulation of white adipose tissue (WAT) browning is considered as a potential approach to treat obesity and metabolic diseases. Our previous studies have shown that phytochemical butein can stimulate WAT through induction Prdm4 in adipocytes. Here, we investigated the effects on diet-induced its underlying molecular mechanism. Treatment with prevented weight gains improved profiles obese mice. Butein treatment groups also displayed higher body temperature, increased energy...
Acquired lymphedema is one of the most dreaded side effects cancer treatment, such as surgical treatment or irradiation. However, due to lack appropriate animal models, there no effective therapeutic method cure acquired lymphedema. To develop a reproducible model, we devised mouse hind limb model by removing superficial inguinal lymph node, popliteal deep and femoral lymphatic vessel. We measured volume lymphedematous leg observed change in level hyaluronic acid (HA) lymphangiogenic factors...
An enantioselective synthetic method for α-alkylserines by the phase-transfer catalytic alkylation of 2-phenyl-2-oxazoline-4-carbonylcamphorsultam (4a) was developed. The α-alkylation 4a using P2-Et at −78 °C gave (75∼99%, 90∼97% de), which could be easily hydrolyzed to α-alkylserines.
The global obesity epidemic and associated metabolic diseases require alternative biological targets for new therapeutic strategies. In this study, we show that a phytochemical sulfuretin suppressed adipocyte differentiation of preadipocytes administration to high fat diet-fed obese mice prevented increased insulin sensitivity. These effects were with expression inflammatory markers, induced adiponectin, levels phosphorylated ERK AKT. To elucidate the molecular mechanism in adipocytes,...
In many countries, vaccines are used for the prevention of foot-and-mouth disease (FMD).However, because there is no protection against FMD immediately after vaccination, research and development on antiviral agents being conducted to induce until immunological competence produced.This study tested whether well-known chemicals as RNA virus treatment had inhibitory effects viruses (FMDVs) demonstrated that ribavirin showed FMDV in vitro/in vivo.In addition, it was observed combining...