A5103160091- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
- Cardiac electrophysiology and arrhythmias
- Viral Infections and Immunology Research
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Healthcare Systems and Practices
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Pericarditis and Cardiac Tamponade
- Aquatic Invertebrate Ecology and Behavior
- Sarcoidosis and Beryllium Toxicity Research
- Infective Endocarditis Diagnosis and Management
- Medication Adherence and Compliance
- Congenital Heart Disease Studies
- Chronic Disease Management Strategies
- Cardiac tumors and thrombi
- Sports injuries and prevention
- Pharmaceutical Practices and Patient Outcomes
University Hospital Limerick
2021
Royal Brompton Hospital
2007-2020
St. Vincent's University Hospital
2007-2020
NIHR Royal Brompton Cardiovascular Biomedical Research Unit
2014-2020
NIHR Bristol Cardiovascular Biomedical Research Unit
2018
University of Bristol
2018
John Radcliffe Hospital
2018
University of Oxford
2018
St Michael’s Hospital
2011-2017
University College Dublin
1997-2016
<h3>Importance</h3>Risk stratification of patients with nonischemic dilated cardiomyopathy is primarily based on left ventricular ejection fraction (LVEF). Superior prognostic factors may improve patient selection for implantable cardioverter-defibrillators (ICDs) and other management decisions.<h3>Objective</h3>To determine whether myocardial fibrosis (detected by late gadolinium enhancement cardiovascular magnetic resonance [LGE-CMR] imaging) an independent incremental predictor mortality...
IMPORTANCEPrevention strategies for heart failure are needed.OBJECTIVE To determine the efficacy of a screening program using brain-type natriuretic peptide (BNP) and collaborative care in an at-risk population reducing newly diagnosed prevalence significant left ventricular (LV) systolic and/or diastolic dysfunction. DESIGN, SETTING, AND PARTICIPANTSThe St Vincent's Screening to Prevent Heart Failure Study, parallel-group randomized trial involving 1374 participants with cardiovascular risk...
This study examined the cardiac structure and function of a unique cohort documented lifelong, competitive endurance veteran athletes (>50 yr). Twelve lifelong male [mean ± SD (range) age: 56 6 yr (50–67)], 20 age-matched controls [60 5 yr; (52–69)], 17 younger [31 (26–40)] without significant comorbidities underwent magnetic resonance (CMR) imaging to assess morphology function, as well CMR with late gadolinium enhancement (LGE) myocardial fibrosis. Lifelong had smaller left (LV) right...
<h3>Objective</h3> Myocardial fibrosis identified by late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) in patients with hypertrophic cardiomyopathy (HCM) is associated adverse events, but its value as an independent risk factor for sudden cardiac death (SCD) unknown. We investigated the role of LGE-CMR stratification HCM. <h3>Methods</h3> conducted a prospective cohort study tertiary referral centre. Consecutive HCM (n=711, median age 56.3 years, IQR 46.7–66.6; 70.0%...
Background— Pathological T-wave inversion (PTWI) is rarely observed on the ECG of healthy athletes, whereas it common in patients with certain cardiac diseases. All interpretation guidelines for use within athletes state that PTWI (except leads aVR, III and V1 V1–V4 when preceded by domed ST segment asymptomatic Afro-Caribbean only) cannot be considered a physiological adaptation. The aims present study were to prospectively determine prevalence pathology presenting PTWI, examine efficacy...
The aetiology and clinical significance of troponin release following endurance exercise is unclear but may be due to transient myocardial inflammation. Cardiovascular magnetic resonance (CMR) affords us the opportunity evaluate presence inflammation focal fibrosis ideal imaging modality study this hypothesis. We sought correlate relationship between acute bouts ultra leading cardiac biomarkers elevation using CMR.
Microvascular dysfunction in HCM has been associated with adverse clinical outcomes. Advances quantitative cardiovascular magnetic resonance (CMR) perfusion imaging now allow myocardial blood flow to be quantified at the pixel level. We applied these techniques investigate spectrum of microvascular hypertrophic cardiomyopathy (HCM) and explore its relationship fibrosis wall thickness.
Abstract Objective This study was undertaken to evaluate the value of cardiovascular magnetic resonance (CMR) in assessment patients with Takayasu arteritis (TA). Methods Sixteen TA and 2 populations comprising 110 normal volunteers were prospectively recruited. All underwent a CMR protocol including measurement carotid artery wall volume, left ventricular (LV) volumes function, late gadolinium enhancement for detection myocardial scarring. Results Carotid total vessel wall:outer ratio...
A growing body of evidence reporting altered cardiac function and myocardial damage after arduous exercise, together with the increased prevalence arrhythmias observed in highly trained athletes, suggests that repetitive bouts prolonged, exercise may be deleterious to long-term health. We report case an experienced, marathon runner who died suddenly while running. On post-mortem examination, left ventricle hypertrophy idiopathic interstitial fibrosis was found. believe life-long, physical...
Seventeen male participants (mean (SD) (range): age 33.5 (6.5) years (46-26 years), body mass 80 (9.2) kg (100-63 kg), height 1.81 (0.06) m (1.93- 1.70 m)) ran a marathon to investigate the relationship between systolic function (using cardiac magnetic resonance (CMR)) and diastolic echocardiography) against biomarkers of damage.Echocardiographic troponin I (cTnI)/N-terminal pro-B-type natriuretic peptide (NTproBNP) data were collected 24 h premarathon, immediately postmarathon 6...
Heart failure (HF) in hypertrophic cardiomyopathy (HCM) is associated with high morbidity and mortality. Predictors of HF, particular the role myocardial fibrosis microvascular ischemia remain unclear. We assessed predictive value cardiovascular magnetic resonance (CMR) for development HF HCM an observational cohort study.