A5100640334- Cancer-related Molecular Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Ubiquitin and proteasome pathways
- interferon and immune responses
- Immune cells in cancer
- Hippo pathway signaling and YAP/TAZ
- Cancer, Hypoxia, and Metabolism
- Cell death mechanisms and regulation
- Immune Cell Function and Interaction
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Alzheimer's disease research and treatments
- Gout, Hyperuricemia, Uric Acid
- Cytokine Signaling Pathways and Interactions
- Retinoids in leukemia and cellular processes
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- S100 Proteins and Annexins
- Immune Response and Inflammation
- Wnt/β-catenin signaling in development and cancer
- Flavonoids in Medical Research
- Inflammasome and immune disorders
- Pain Mechanisms and Treatments
- Lipid metabolism and biosynthesis
- RNA Interference and Gene Delivery
Shanghai University of Traditional Chinese Medicine
2019-2023
People's Liberation Army 401 Hospital
2017
Xiamen University
2009-2015
Army Medical University
2010
Xinqiao Hospital
2010
The role of the unfolded protein response (UPR) in tissue homeostasis remains largely unknown. Here we find that loss Mst1/2, mammalian Hippo orthologues, or their regulator WW45, leads to a remarkably enlarged endoplasmic reticulum (ER) size-associated UPR. Intriguingly, attenuation UPR by tauroursodeoxycholic acid (TUDCA) diminishes Mst1/2 mutant-driven liver overgrowth and tumorigenesis promoting nuclear exit degradation downstream effector Yap. Yap is required for activity ER expansion...
The transcriptional coactivator Yes-associated protein (YAP) plays an important role in organ-size control and tumorigenesis. However, how Yap gene expression is regulated remains unknown. This study shows that the Ets family member GABP binds to promoter activates YAP transcription. depletion of downregulates YAP, resulting a G1/S cell-cycle block increased cell death, both which are substantially rescued by reconstituting YAP. can be inactivated oxidative mechanisms, acetaminophen-induced...
Non-small-cell lung cancer (NSCLC) remains the most common malignancy with highest morbidity and mortality worldwide. In our previous study, we found that a classic traditional Chinese medicine (TCM) formula Ze-Qi-Tang (ZQT), which has been used in treatment of respiratory diseases for thousands years, could directly inhibit growth human NSCLC cells via p53 signaling pathway. this explored immunomodulatory functions ZQT. We ZQT significantly prolonged survival orthotopic model mice by...
Natural killer (NK) cells, a key member of innate lymphocytes, are promising immunotherapeutic target for ischemic stroke. Astragaloside IV (ASIV) is isolated from Astragalus mongholicus Bunge (Fabaceae), herbal medicine possessing immunomodulatory ability. This study investigated the effect ASIV on NK cells during acute stage brain injury in mouse model middle cerebral artery occlusion (MCAO). MCAO mice treated with had better functional outcomes, smaller infarction and less cell...
Chronic pain is highly prevalent. Individuals with cognitive disorders such as Alzheimer disease are a susceptible population in which frequently difficult to diagnosis. It still unclear whether the pathological changes patients will affect processing. Here, we leverage animal behavior, neural activity recording, optogenetics, chemogenetics, and modeling examine contribution of anterior cingulate cortex (ACC) neurons response. The 5× familial mice show alleviated mechanical allodynia can be...
Ketamine is a widely used intravenous anesthetic; however, basic and clinical studies have demonstrated that prolonged exposure can cause irreversible injury to the immature human brain. Yes‑associated protein (YAP) main effector of Hippo signaling pathway, which serves an important role in regulating tissue homeostasis organ size during development. However, whether YAP mediates ketamine‑induced apoptosis not completely understood. Based on functions resistance cell self‑renewal regulation,...
Abstract Background: Neuroinflammation is one of the most important contributing factors for pathogenesis Alzheimer’s disease (AD). Cyclooxygenase-1 (COX-1) distinctly expressed in microglia and involved activation neuroinflammation AD. However, molecular mechanisms by which COX-1 regulated participated AD progression remains unclear. This study was designed to investigate cellular underlying regulation neuroinflammation. Methods: C57BL/6J, 5×FAD 5×FAD/COX-1 knockout (KO) mice different ages...
Hydrogen sulfide (H<sub>2</sub>S) is found to be the third endogenous gaseous transmitter and plays an important role in many systems of organism. In cardiovascular system, H<sub>2</sub>S produced endogenously by cystathionine gamma-lyase (CSE). The CSE/H<sub>2</sub>S system executes physiological function vasorelaxation, inhibition vascular remodelling cardioprotection. It also concerned with variety diseases such as hypertension pulmonary hypertension. These results suggest that H2S may a...
Abstract Background: The high incidence and mortality of lung cancer has been a widespread concern in the world, among which non-small cell (NSCLC)accounts for more than 85% cancer, its 5-year prognosis is pretty poor. Accumulating studies have shown that traditional Chinese medicine (TCM) active ingredients good anti-tumor activity. Based on results our previous high-throughput screening, it was first time to find Thevebioside (THB, an ingredient from TCM) sensitive NSCLC cells, then we...