A5100674059- Reproductive Biology and Fertility
- Cannabis and Cannabinoid Research
- Ovarian function and disorders
- Plant biochemistry and biosynthesis
- Hippo pathway signaling and YAP/TAZ
- Carcinogens and Genotoxicity Assessment
- Circadian rhythm and melatonin
- CRISPR and Genetic Engineering
- Connexins and lens biology
- DNA Repair Mechanisms
- Diet, Metabolism, and Disease
- Cancer therapeutics and mechanisms
- Plant Gene Expression Analysis
- Plant Reproductive Biology
- Drug Transport and Resistance Mechanisms
- Heat shock proteins research
- Endometriosis Research and Treatment
- Photosynthetic Processes and Mechanisms
- Antibiotic Resistance in Bacteria
- Gestational Trophoblastic Disease Studies
- Pharmacogenetics and Drug Metabolism
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Crop Yield and Soil Fertility
- Sperm and Testicular Function
National Center for Toxicological Research
2021-2025
United States Food and Drug Administration
2021-2025
Lanzhou Institute of Husbandry and Pharmaceutical Sciences
2024-2025
Chinese Academy of Agricultural Sciences
2024-2025
Ministry of Agriculture and Rural Affairs
2024-2025
British Columbia Children's Hospital
2024
University of British Columbia
2022-2024
Shanghai University of Sport
2024
Fujian Medical University
2024
Jiangnan University
2024
Cannabidiol (CBD), one of the major components extracted from plant Cannabis sativa L., has been used as a prescription drug to treat seizures in many countries. CBD-induced male reproductive toxicity reported animal models; however, underlying mechanisms remain unclear. We previously that CBD induced apoptosis primary human Leydig cells, which constitute steroidogenic cell population testicular interstitium. In this study, we investigated effects and its metabolites on TM3 mouse cells. CBD,...
Steroidogenic acute regulatory protein (StAR) mediates the rate-limiting step in ovarian steroidogenesis and progesterone (P4) synthesis.Melatonin its receptors are expressed human granulosa cells, have been shown to influence basal P4 production.However, previous studies addressing regulation of StAR expression by melatonin impact on secretion yielded contradictory results.Here, we demonstrate that upregulates primary cultures granulosa-lutein (hGL) cells obtained from women undergoing...
Abstract Ovarian hyperstimulation syndrome (OHSS) is one of the most serious and iatrogenic complications that can occur during in vitro fertilization treatment. Although pathogenesis OHSS not fully understood, vascular endothelial growth factor (VEGF) has been recognized as an important mediator development OHSS. Transforming factor-beta-1 (TGF-β1) known to regulate various ovarian functions. However, whether VEGF be regulated by TGF-β1 human granulosa cells determined. In addition, role...
About 14% of veterans who suffer from Gulf war illness (GWI) complain some form gastrointestinal disorder but with no significant markers clinical pathology. Our previous studies have shown that exposure to GW chemicals resulted in altered microbiome which was associated damage molecular pattern (DAMP) release followed by neuro and inflammation loss gut barrier integrity. Enteric glial cells (EGC) are emerging as important regulators the tract been observed change a reactive phenotype...
Abstract Background Manchurian walnut (Juglans mandshurica Maxim.) is a tree with multiple industrial uses and medicinal properties in the Juglandaceae family (walnuts hickories). J. produces juglone, which toxic allelopathic agent has potential utilization value. Furthermore, seed of rich various unsaturated fatty acids high nutritive Findings Here, we present high-quality chromosome-scale reference genome assembly annotation for (n = 16) contig N50 21.4 Mb by combining PacBio high-fidelity...
Abstract Cannabidiol (CBD), one of the major cannabinoids in plant Cannabis sativa L., is active ingredient a drug approved for treatment seizures associated with certain childhood-onset epileptic disorders. CBD has been shown to induce male reproductive toxicity multiple animal models. We previously reported that inhibits cellular proliferation mouse Sertoli cell line TM4 and primary human cells. In this study, using transcriptomic approach mRNA-sequencing analysis, we identified molecular...
The loss of contact inhibition is a key step during carcinogenesis. Hippo-Yes-associated protein (Hippo/YAP) pathway an important regulator cell growth in density-dependent manner. However, how Hippo signaling senses density this context remains elusive. Here, we report that high induced the phosphorylation spectrin α chain, nonerythrocytic 1 (SPTAN1), plasma membrane-stabilizing protein, to recruit NUMB endocytic adaptor isoforms and 2 (NUMB1/2), which further sequestered microtubule...
Does amphiregulin (AREG), the most abundant and important epidermal growth factor receptor (EGFR) ligand in follicular fluid, regulate aromatase expression human granulosa-lutein (hGL) cells?AREG mediates hCG-induced up-regulation of estradiol (E2) production hGL cells.AREG secretion are rapidly induced by hCG cells mediate physiological functions LH/hCG ovary. EGFR protein is expressed follicles not only pre-ovulatory phase but also throughout luteal menstrual cycle. After LH surge, corpus...
Abstract Ovarian hyperstimulation syndrome (OHSS) is one of the most life-threatening and potentially fatal complications associated with controlled ovarian (COH) during in vitro fertilization (IVF) treatment. Although pathogenesis OHSS remains unclear, elevated serum estradiol (E2) levels before human chorionic gonadotropin (hCG) administration are risk OHSS. The pineal hormone melatonin its receptors expressed granulosa cells have been shown to stimulate E2 production. However, effect on...
Abstract Background During pregnancy, trophoblast cell invasion needs to be finely controlled. Aberrant is associated with placental diseases. Epidermal growth factor (EGF) and its receptor, EGFR, are expressed in cells. Although the pro-invasive effect of EGF on cells has been reported, underlying mechanism remains largely unknown. Results In present study, we conducted an RNA sequencing (RNA-seq) HTR-8/SVneo human response identified KISS1 as a target gene EGF. The encodes kisspeptin, also...
The objectives of the study were to design, synthesize, and evaluate antibacterial activity a series novel aminoguanidine-indole derivatives. Thirty-seven new compounds effectively synthesized through nucleophilic substitution reaction guanidinylation reaction. Chemical structures all desired identified by NMR HR-MS spectroscopy. Most showed significant against ESKAPE pathogens clinical resistant Klebsiella pneumoniae (K. pneumoniae) isolates. K. is an important opportunistic pathogen that...
In recent decades, there has been a notable increase in research activity focused on the aversive and reward circuits of brain. The evidence indicates that parabrachial nucleus (PBn) is crucial element generation aversion responses mice. Following successful stimulation PBn, mice display increased stress-related behaviours. study employs Fos TRAP2-ChR2 mice, opioids such as oxycodone, range imaging technologies to monitor manipulate neural pathways. Behavioral tests optogenetic manipulation...
Abstract Mixed application of controlled‐release and normal urea (MCU) is considered as a promising alternative to farmers’ practice with one‐time nitrogen fertilization (FP) optimal split (OPT). In this study, MCU effectiveness on maize ( Zea mays L.) were investigated by conducting 2‐yr field experiments sandy clay soils. Across the 2 yr, grain yields in increased 22 18% relative FP sand soils, respectively, net returns 65 19%, while total N losses reduced 228 193 kg ha −1 , respectively....