A5103135228- Cancer Genomics and Diagnostics
- Prenatal Screening and Diagnostics
- Cancer-related gene regulation
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Research in Cotton Cultivation
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- dental development and anomalies
- Mitochondrial Function and Pathology
- Genetic Syndromes and Imprinting
- Hemophilia Treatment and Research
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- Congenital heart defects research
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Acute Lymphoblastic Leukemia research
- Photosynthetic Processes and Mechanisms
- Oral and gingival health research
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- ATP Synthase and ATPases Research
- Platelet Disorders and Treatments
Southern Medical University
2020-2025
Heilongjiang Academy of Sciences
2025
Harbin Medical University
2010-2025
Chongqing Medical University
2025
Second Affiliated Hospital of Harbin Medical University
2025
Dalian Medical University
2017-2024
Second Affiliated Hospital of Dalian Medical University
2024
Hunan University
2024
Zhengzhou University
2023-2024
China Agricultural University
2015-2024
BRCA1 is an important mediator of the DNA damage response, which promotes homologous recombination (HR) and antagonizes 53BP1-dependent non-homologous end joining in S/G2 phase. But how this achieved remains unclear. Here, we report that E3 ubiquitin ligase UHRF1 (Ubiquitin-like, with PHD RING finger domains 1) directly participates interplay between 53BP1. Mechanistically, recruited to double-strand breaks (DSBs) by S phase, requires BRCT domain phosphorylated Ser674 UHRF1. Subsequently,...
Abnormal metabolism and uncontrolled angiogenesis are two important characteristics of malignant tumors. The occurrence both events involves many key molecular changes including miRNA. However, EBV encoded miRNAs rarely mentioned as capable regulating tumor angiogenesis. Here, we reported that one the by EBV, EBV-miR-Bart1-5P, can significantly promote nasopharyngeal carcinoma (NPC) cell glycolysis induces in vitro vivo. Mechanistically, EBV-miR-Bart1-5P directly targets α1 catalytic subunit...
Oxidative stress, which can be activated by a variety of environmental risk factors, has been implicated as an important pathogenic factor for inflammatory bowel disease (IBD). However, how oxidative stress drives IBD onset remains elusive. Here, we found that was strongly in inflamed tissues from both ulcerative colitis patients and Crohn’s patients, it caused nuclear-to-cytosolic TDP-43 transport reduction the protein level. To investigate function IBD, inducibly deleted exons 2 to 3...
Abstract Barth syndrome is an X-linked disorder caused by loss-of-function mutations in Tafazzin (TAZ), acyltransferase that catalyzes remodeling of cardiolipin, a signature phospholipid the inner mitochondrial membrane. Patients develop cardiac and skeletal muscle weakness, growth delay neutropenia, although phenotypic expression varies considerably between patients. Taz knockout mice recapitulate many hallmark features disease. We used mouse genetics to test hypothesis genetic modifiers...
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated cancer characterized by a high degree of recurrence, angiogenesis, and metastasis. The importance alternative pro-angiogenesis pathways including viral factors has emerged after decades directly targeting various signaling components. Using NPC as model, we identified essential oncogenic pathway underlying angiogenesis regulation that involves the inhibition tumor suppressor, Spry3, its downstream targets...
The gut microbiota in the hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF) is poorly defined. We aim to uncover characteristics of HBV-ACLF and other HBV associated pathologies. analyzed microbiome patients with or pathologies healthy individuals by 16S rRNA sequencing metagenomic fecal samples. 212 HBV-ACLF, 252 chronic (CHB), 162 HBV-associated cirrhosis (HBV-LC) 877 were recruited for study. CHB HBV-LC are grouped as HBV-Other. discovered striking differences diversity...
Traditional Chinese herbal medicines are a great source of cancer chemotherapeutic agents. Tubeimoside-1 (TBMS1) is triterpenoid saponin extracted from Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae), herb with anticancer potential named as "Tu Bei Mu". In the present study, we used proteomics to examine cytotoxic effects TBMS1 on HeLa cells. Protein profiling TBMS1-treated cells revealed profound protein alterations related energy metabolism and synthesis folding, suggesting that...
Congenital scoliosis (CS) is a birth defect with variable clinical and anatomical manifestations due to spinal malformation. The genetic etiology underlying about 10% of CS cases in the Chinese population compound inheritance by which gene dosage reduced below that haploinsufficiency. In this model, trait manifests as result combined effect rare variant common pathogenic allele at locus. From exome sequencing (ES) data 523 patients Asia two Texas, we identified six TBX6 gene-disruptive...
BackgroundCoronary artery fistula (CAF) is a rare coronary anomaly. With the advances in echocardiographic techniques, more cases of CAF have been identified. This study aimed to systematically evaluate detection rate, clinical characteristics, treatment strategies, and prognosis children.MethodsA retrospective was conducted on 326,315 pediatric patients who underwent echocardiography between January 2017 2023. Of these, 920 were diagnosed with CAF, corresponding rate 0.28%.ResultsThe found...
Acute-on-chronic liver failure (ACLF) is a severe clinical syndrome, and the incidence of invasive fungal infection (IFI) among hospitalized patients with ACLF steadily increasing. The aim this study to develop diagnostic nomogram assist in identification IFI these patients. A retrospective included 705 from January 1, 2019, October 31, 2023, randomly divided into training (n = 493) validation 212) cohorts. diagnosis includes proven probable diagnosis. Kaplan analysis was performed analyze...
Background and purpose: Ponatinib, a tyrosine kinase inhibitor (TKI) leads to hypertension; however, the mechanisms remain elusive. We aimed investigate whether lysine acetyltransferase 7 (KAT7), key regulator of cellular senescence that is closely associated with cardiovascular diseases, involves in ponatinib-induced hypertension. Methods results: After administering ponatinib Sprague–Dawley (SD) rats for 8 days, we measured blood pressure, vasodilation, endothelial function using tail-cuff...
Background Preterm birth (PTB) occurs in approximately 11% of all births worldwide, resulting significant morbidity and mortality for both mothers their offspring. Identifying pregnancies at risk preterm during early pregnancy may help improve interventions reduce its incidence. Plasma cell-free DNA (cfDNA), derived from placenta other maternal tissues, serves as a dynamic indicator biological processes pathological changes pregnancy. These properties establish cfDNA valuable biomarker...
ABSTRACT Objectives Nanopore sequencing shows advantages in detecting single nucleotide variations (SNVs), deletions, and complex structural variants as a test thalassemia. However, the performance evaluation or verification of this method remains unestablished, which is essential before clinical utility panel registration. Here, we developed classification for thalassemia mutations, enabling automated interpretation, visual representation, identification diverse mutation types. Methods We...
Abstract Retinoid X receptor alpha (RXRα) and its N-terminally truncated version, tRXRα, are widely implicated in cancer development represent intriguing targets for prevention treatment. Successful manipulation of RXRα tRXRα requires the identification their modulators that could produce therapeutic effects. Here, we report a class nitrostyrene derivatives bind to by unique mechanism, which nitro group Cys432 required binding. The binding results potent activation Gal4-DBD-RXRα-LBD...
Abstract Dental follicle cells (DFCs) activate and recruit osteoclasts for tooth development eruption, whereas DFCs themselves differentiate into osteoblasts to form alveolar bone surrounding roots through the interaction with Hertwig's epithelial root sheath (HERS). Also during development, parathyroid hormone‐related peptide (PTHrP) is expressed germ. Thus, we aimed investigate effect of PTHrP (1–34) on resorption osteogenesis in vitro vivo. In studies demonstrated that cocultured HERS...
Wnt/β-catenin signaling plays a critical role in colonic carcinogenesis. However, non-coding RNAs (ncRNA) transcriptionally regulated by β-catenin are largely unknown. Herein, we found that lncRNA MIR100HG (lnc-MIR100HG) negatively correlated with target genes of from The Cancer Genome Atlas colorectal carcinoma database, which was verified 48 paired specimens. In addition, constitutive overexpression decreased primary and mature lnc-MIR100HG levels, whereas blockage activity siRNA or...
Squamous esophageal carcinoma is highly prevalent in developing countries, especially China. Tu Bei Mu (TBM), a traditional folk medicine, has been used to treat squamous cell (ESCC) for long term. tubeimoside I (TBMS1) the main component of TBM, exhibiting great anticancer potential. In this study, we investigated mechanism TBMS1 cytotoxic effect on EC109 cells.Comparative nuclear proteomic approach was applied current study and identified several altered protein spots. Further biochemical...
The epithelial sodium channel (ENaC) is expressed in endothelial cells and acts as a negative modulator of vasodilatation. Oxidized LDL (ox-LDL) key pathological factor dysfunction. In the present study we examined role ENaC ox-LDL-induced dysfunction its associated signal transduction pathway.Patch clamp techniques combined with pharmacological approaches were used to examine activity split-open mouse thoracic aorta. Western blot analysis was determine expression aorta relaxation measured...