A5007416894- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Computational Drug Discovery Methods
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Advanced Photocatalysis Techniques
- Bacteriophages and microbial interactions
- interferon and immune responses
- COVID-19 Clinical Research Studies
- Climate Change and Health Impacts
- MXene and MAX Phase Materials
- Copper-based nanomaterials and applications
- Global Public Health Policies and Epidemiology
- Cancer, Hypoxia, and Metabolism
- 2D Materials and Applications
- Global Health Care Issues
- Heusler alloys: electronic and magnetic properties
- Global Maternal and Child Health
- COVID-19 and healthcare impacts
- Viral gastroenteritis research and epidemiology
- Protein Structure and Dynamics
- Physics of Superconductivity and Magnetism
- Poxvirus research and outbreaks
University of Swat
2014-2025
Qatar University
2023-2025
Benazir Bhutto Hospital
2025
Clemson University
2024-2025
Sejong University
2022-2024
The University of Agriculture, Peshawar
2018-2024
University of Washington
2022-2024
Institute for Health Metrics and Evaluation
2022-2024
Bacha Khan University
2024
University of Agriculture Faisalabad
2024
Abstract The evolution of the SARS‐CoV‐2 new variants reported to be 70% more contagious than earlier one is now spreading fast worldwide. There an instant need discover how interact with host receptor (ACE2). Among mutations in Spike glycoprotein variants, three are specific receptor‐binding domain (RBD) and required insightful scrutiny for therapeutic options. These structural evolutions RBD may impart a critical role unique pathogenicity variants. Herein, using biophysical approaches, we...
Mucosal vaccination induces targeted CD8 + T cell homing to inhibit mucosal tumors.
Cancer is caused by a complex interaction of factors that interrupt the normal growth and division cells. At center this process intricate relationship between DNA damage cellular mechanisms responsible for maintaining genomic stability. When not repaired, it can cause genetic mutations contribute to initiation progression cancer. On other hand, response system, which involves phosphorylation histone variant H2AX (γH2AX), crucial in preserving integrity signaling facilitating repair...
Abstract It is well known that c-Src has important roles in tumorigenesis. However, it remains unclear whether contributes to metabolic reprogramming. Here we find can interact with and phosphorylate hexokinases HK1 HK2, the rate-limiting enzymes glycolysis. Tyrosine phosphorylation dramatically increases their catalytic activity thus enhances Mechanistically, of at Tyr732 robustly decreases its K m V max by disrupting dimer formation. Mutation site either or HK2 remarkably abrogates...
The current coronavirus (SARS-COV-2) pandemic and phenomenal spread to every nook cranny of the world has raised major apprehensions about modern public health care system. So far as a result this epidemic, 4,434,653 confirmed cases 302,169 deaths are reported. growing infection rate death toll demand use all possible approaches design novel drugs vaccines curb disease. In study, we combined repurposing virtual drug screening strategies target 3CLpro, which an essential role in viral...
Abstract Post‐combustion CO 2 capture from the power and industrial sectors has gained widespread attention due to its ability retrofit easily with newly installed existing plants. This state‐of‐the‐art, updated review provides an overview of technical issues in post‐combustion related process performance, energy requirements for capture, inconsistencies prediction cost. Recent updates are presented regarding chemical absorption‐desorption systems, particularly absorption solubility...
Monkeypox virus is the causative agent of monkeypox disease, belonging to an orthopoxvirus genus, with a disease pattern similar that smallpox. The number cases have robustly increased recently in several countries around world, potentially causing international threat. Therefore, serious measures are indispensable be taken mitigate spread and hence, under these circumstances, vaccination best choice neutralize virus. In current study, we used immunoinformatic approaches target L1R, B5R,...
To investigate whether COVID-19 patients with pulmonary embolism had higher mortality and assess the utility of D-dimer in predicting acute embolism.Using National Collaborative retrospective cohort, a cohort hospitalized was studied to compare 90-day intubation outcomes without multivariable cox regression analysis. The secondary measured 1:4 propensity score-matched analysis included length stay, chest pain incidence, heart rate, history or DVT, admission laboratory parameters.Among 31,500...
Reprogramming of glucose metabolism is a key event in tumorigenesis and progression. Here, we show that active c-Src stimulates glycolysis by phosphorylating (Tyr194) activating PFKFB3, enzyme boosts producing fructose-2,6-bisphosphate PFK1. Increased intermediates replenish non-oxidative pentose phosphate pathway (PPP) serine for biosynthesis cancer cells. PFKFB3 knockout (KO) cells their counterpart reconstituted with PFKFB3-Y194F comparably impaired abilities proliferation, migration,...
A new variant of SARS-CoV-2 known as the omicron (B.1.1.529) reported in South Africa with 30 mutations whole spike protein, among which 15 are receptor-binding domain, is continuously spreading exponentially around world. The to be highly contagious antibody-escaping activity. emergence variants alarming, and thus quick discovery small molecule inhibitors needed. Hence, current study uses computational drug screening molecular dynamics simulation approaches (replicated) identify novel drugs...