A5103097714- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Bioactive Compounds and Antitumor Agents
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- Microbial Natural Products and Biosynthesis
- Cancer Immunotherapy and Biomarkers
- Computational Drug Discovery Methods
- Glycosylation and Glycoproteins Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- ATP Synthase and ATPases Research
- Gastric Cancer Management and Outcomes
- Genetic Associations and Epidemiology
- Renal and related cancers
- Trace Elements in Health
- Model Reduction and Neural Networks
- Renal cell carcinoma treatment
- Medicinal Plant Pharmacodynamics Research
- Seaweed-derived Bioactive Compounds
- Immune cells in cancer
- Bioinformatics and Genomic Networks
- Cytokine Signaling Pathways and Interactions
- Lung Cancer Treatments and Mutations
Wenzhou Medical University
2022-2025
First Affiliated Hospital of Wenzhou Medical University
2022-2025
Zhejiang University
2024
Ruian People's Hospital
2023-2024
Sir Run Run Shaw Hospital
2024
China Medical University
2022
BackgroundLactylation is a significant post-translational modification bridging the gap between cancer epigenetics and metabolic reprogramming. However, association lactylation prognosis, tumor microenvironment (TME), response to drug therapy in various cancers remains unclear.MethodsFirst, expression, prognostic value, genetic epigenetic alterations of genes were systematically explored pan-cancer manner. Lactylation scores derived for each using single-sample gene set enrichment analysis...
Abstract NUP155 is reported to be correlated with tumor development. However, the role of in physiology and immune microenvironment (TIME) has not been previously examined. This study comprehensively investigated expression, immunological function, prognostic significance different cancer types. Bioinformatics analysis revealed that was upregulated 26 types cancer. Additionally, upregulation strongly advanced pathological or clinical stages poor prognosis several cancers. Furthermore,...
As the primary component of anti-tumor immunity, T cells are prone to exhaustion and dysfunction in tumor microenvironment (TME). A thorough understanding cell (TEX) TME is crucial for effectively addressing TEX clinical settings promoting efficacy immune checkpoint blockade therapies. In eukaryotes, numerous surface proteins tethered plasma membrane via Glycosylphosphatidylinositol (GPI) anchors, which play a role facilitating proper translocation proteins. However, available evidence...
The tumor microenvironment of breast cancer encompasses a broad spectrum immune cell populations. These populations are biologically/clinically relevant to varying degrees. causal relationship between these cells and remains uncertain despite their relevance. Bi-directional two-sample Mendelian randomization (MR) analyses were conducted investigate the 731 phenotypes cancer, utilizing genome-wide association study (GWAS) statistics. primary analytical methods employed weighted median (WM)...
Aging | doi:10.18632/aging.204967. Yufeng Qi, Haodong Wu, Tianru Zhu, Zitian Liu, Conghui Congzhi Yan, Zhixuan Yiying Xu, Ying Bai, Lehe Yang, Dezhi Cheng, Xiaohua Zhang, Haiyang Zhao, Chengguang Xuanxuan Dai
Background and Purpose: Breast cancer (BRCA) is the most frequent female malignancy potentially life threatening. The amino acid metabolism (AAM) has been shown to be strongly associated with development progression of human malignancies. In turn, long noncoding RNAs (lncRNAs) exert an important influence on regulation metabolism. Therefore, we attempted build AAM-related lncRNA prognostic model for BRCA illustrate its immune characteristics molecular mechanism. Experimental Design: RNA-seq...
Background Patients with pancreatic duct adenocarcinoma (PDAC) have varied prognoses that depend on numerous variables. However, additional research is required to uncover the latent impact of ubiquitination-related genes (URGs) determining PDAC patients’ prognoses. Methods The URGs clusters were discovered via consensus clustering, and prognostic differentially expressed (DEGs) across utilized develop a signature using least absolute shrinkage selection operator (LASSO) regression analysis...
Reactive oxygen species play a crucial role in the prognosis and tumor microenvironment (TME) of malignant tumors. An ROS-related signature was constructed gastric cancer (GC) samples from TCGA database. genes were obtained Molecular Signatures Database. Consensus clustering used to establish distinct subtypes related different survival immune cell infiltration patterns. Sequentially, prognostic identified subtypes, which identify stable that predicted GC. Correlation analysis revealed...
aims: To investigate the expression of HMGN1 in different types cancer and its potential role diagnosis prognosis. background: The High Mobility Group N (HMGN) family genes includes Nucleosomal Binding Domain 1 Gene (HMGN1), which is crucial for epigenetic regulation. However, specific function development not known. objective: method: Raw data on were procured from Genotype-Tissue [removed]GTEx), University Alabama- Birmingham CANcer analysis Portal (UALCAN), Cancer Genome Atlas (TCGA)....
Increasing evidence highlights the important role of ubiquitination in cancer. The objective our study is to establish a reliable marker for predicting clinical outcomes and treatment responses patients with clear cell renal carcinoma (ccRCC) using genes related (URGs). URGs subtypes were identified consensus clustering based on TCGA-KIRC, signature containing prognostic differentially expressed was determined LASSO Cox regression analysis. To demonstrate strength signature, verification...
The impact of primary site surgery on survival remains controversial in female patients with stage IV breast cancer. purpose this study was to investigate the role tumor cancer and concurrently develop a nomogram identify which will benefit from surgery.We retrospectively searched SEER database for newly diagnosed infiltrating duct carcinoma (BIDC) between 2010 2015 then divided them into non-surgery groups. propensity score matching (PSM) method implemented eliminate bias, Kaplan-Meier...
The high incidence of breast cancer (BC) prompted us to explore more factors that might affect its occurrence, development, treatment, and also recurrence. Dysregulation cholesterol metabolism has been widely observed in BC; however, the detailed role how affects chemo-sensitivity, immune response, as well clinical outcome BC is unknown.With Mendelian randomization (MR) analysis, potential causal relationship between genetic variants risk was assessed first. Then we analyzed 73...
Recently, studies have shown that immune checkpoint-related genes (ICGs) are instrumental in maintaining homeostasis and can be regarded as potential therapeutic targets. However, the prognostic applications of ICGs require further elucidation low-grade glioma (LGG) cases. In present study, a unique gene signature LGG has been identified validated well based on means facilitating clinical decision-making. The RNA-seq data corresponding samples retrieved utilizing Cancer Genome Atlas (TCGA)...