A5069704550- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Extracellular vesicles in disease
- Urinary Bladder and Prostate Research
- Cancer Research and Treatments
- Advanced biosensing and bioanalysis techniques
- Urinary and Genital Oncology Studies
- Cancer, Hypoxia, and Metabolism
- Gold and Silver Nanoparticles Synthesis and Applications
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Biosensors and Analytical Detection
- Renal and related cancers
- RNA modifications and cancer
- Identification and Quantification in Food
- MicroRNA in disease regulation
- Aquaculture Nutrition and Growth
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- Aquaculture disease management and microbiota
- Cancer, Lipids, and Metabolism
- Urologic and reproductive health conditions
- Phytochemistry and biological activity of medicinal plants
- Reproductive biology and impacts on aquatic species
Ningbo University
2012-2025
Ningbo First Hospital
2015-2024
National University of Defense Technology
2024
Zhejiang Lab
2024
Fuzhou University
2024
Ningbo University Affiliated Hospital
2023
Jilin University
2022
Zhejiang University
2017-2022
Ningbo Center for Disease Control and Prevention
2022
Shanghai Electric (China)
2022
We report here the ~670 Mb genome assembly of Asian seabass (Lates calcarifer), a tropical marine teleost. used long-read sequencing augmented by transcriptomics, optical and genetic mapping along with shared synteny from closely related fish species to derive chromosome-level contig N50 size over 1 scaffold 25 that span ~90% genome. The population structure L. calcarifer complex was analyzed re-sequencing 61 individuals representing various regions across species’ native range. SNP analyses...
Diagnosis and stratification of prostate cancer (PCa) patients using the prostate-specific antigen (PSA) test is challenging. Extracellular vesicles (EVs), as a new star liquid biopsy, has attracted interest to complement inaccurate PSA screening invasiveness tissue biopsy. In this study, panel potential small EV (sEV) protein biomarkers identified from PCa cell lines label-free LC-MS/MS proteomics. These underwent further validation with plasma urine samples different stages through...
Cyclophosphamide is commonly used in the treatment of various cancers and autoimmune diseases, while concurrently imposing substantial toxicity on bladder, frequently manifesting hemorrhagic cystitis. Intravesical interventions, such as hyaluronic acid supplementation, present a therapeutic strategy to reinstate bladder barrier function alleviate effects metabolic toxicants. However, it remains great challenge achieve efficient cyclophosphamide-induced cystitis (CHC) management with...
Zebrafish males undergo a "juvenile ovary-to-testis" gonadal transformation process. Several genes, including nuclear receptor subfamily 5, group A (nr5a) and anti-Müllerian hormone (amh), pathways such as Tp53-mediated germ-cell apoptosis have been implicated in zebrafish testis formation. However, our knowledge of the regulation this complex process is incomplete, much remains to be investigated about molecular network genes that control it. Using microarray-based analysis transforming...
Abstract Background Bladder cancer (BC) is a very common urinary tract malignancy that has high incidence and lethality. In this study, we identified BC biomarkers described new noninvasive detection method using serum urine samples for the early of BC. Methods Serum were retrospectively collected from patients with (n = 99) healthy controls (HC) 50), expression levels 92 inflammation-related proteins examined via proximity extension analysis (PEA) technique. Differential protein was then...
Growth is an economically important trait in aquaculture. To improve growth of the Asian seabass (Lates calcarifer) we have been carrying out, since 2004, a selective breeding program. This study focuses on traits F2 fish generation, comprised offspring from 23 mass crosses 383 F1 brooders. Using genotyping analysis for 10 microsatellites both brood stock and progeny reconstructed pedigree each mass-cross. For generation at 90 days post hatch (dph), recorded body weight (BW) 12,117...
The ideal orthopedic implant has sufficient biomechanical strength and physiological activity to coordinate with the intricate healing process of tissue. Herein, multifunctional stimuli-responsive metal–organic framework (MOF) hydrogels on surface sulfonated long carbon fiber reinforced polyetheretherketone (LCFRPEEK) using UV-grafting method is constructed osseointegration process. are composed nano-hydroxyapatite cored magnesium-gallic acid (HAP@Mg-GA) MOF nanoparticles methacryloyl...
Abstract Background The Asian seabass (Lates calcarifer) is a protandrous hermaphrodite that typically matures as male at approximately 2–4 years of age and then changes sex in subsequent years. Although several sexual maturation stages have been described histologically for both testis ovary, the underlying gene expression profiles remain lacking. development platform therefore necessary to improve our understanding gonad this cultured teleost species. Methods Thirty gonads were collected...
Vaccination is an important strategy in the protection of aquaculture species from major diseases. However, we still do not have a good understanding mechanisms underlying vaccine-induced disease resistance. This further complicated by presence several lymphoid organs that play different roles when mounting immune response. In this study, attempt to elucidate some these using microarray-based approach. Asian seabass (Lates calcarifer) were vaccinated against Streptococcus iniae and...
The receptor-interacting protein kinase 3 (RIP3/RIPK3) was recently found to be a critical regulator of programmed necrosis/necroptosis. However, the biological role and clinical significance RIP3 in prostate cancer remain obscure.Western blotting QRT-PCR were performed detect level cells. Fixed tissue normal specimens subjected immunohistochemical analysis RIP3. Cell migration invasion abilities evaluated by transwell assays. In vitro proliferative ability examed MTS. And vivo nude mice...
Abstract Background Neoadjuvant chemotherapy followed by radical cystectomy (RC) is the standard of care for patients with muscle‐invasive bladder cancer (MIBC). However, treatment outcomes are suboptimal. Camrelizumab, a PD‐1 blockade, has shown benefits in several tumors. This study aimed to investigate efficacy and safety neoadjuvant camrelizumab combination gemcitabine plus cisplatin (GC) RC MIBC patients. Methods was multi‐center, single‐arm that enrolled clinical stage T2‐4aN0‐1M0,...