A5100447123- Chronic Kidney Disease and Diabetes
- Bladder and Urothelial Cancer Treatments
- Renal and Vascular Pathologies
- Antiplatelet Therapy and Cardiovascular Diseases
- Traditional Chinese Medicine Analysis
- Photodynamic Therapy Research Studies
- Acute Myocardial Infarction Research
- Nanoplatforms for cancer theranostics
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Renal Diseases and Glomerulopathies
- Surgical Simulation and Training
- Receptor Mechanisms and Signaling
- Acute Kidney Injury Research
- Lymphoma Diagnosis and Treatment
- Phytochemicals and Antioxidant Activities
- Growth Hormone and Insulin-like Growth Factors
- Mast cells and histamine
- Cancer Mechanisms and Therapy
- Nitric Oxide and Endothelin Effects
- Steroid Chemistry and Biochemistry
- Oral and Craniofacial Lesions
- Anatomy and Medical Technology
- RNA Research and Splicing
East China University of Science and Technology
2020-2024
Shandong Provincial Institute of Dermatology and Venereology
2023
Shandong Provincial Hospital
2023
Shandong First Medical University
2023
Second People’s Hospital of Yibin
2023
The First Affiliated Hospital, Sun Yat-sen University
2022-2023
Sun Yat-sen University
2022-2023
Tianjin University
2003-2023
Tianjin Hospital
2022-2023
Third Affiliated Hospital of Southern Medical University
2019-2023
Background Programmed cell death 1 (PD-1) blockade induces tumor regression in patients with advanced esophageal squamous carcinoma (ESCC); however, little is known about the efficacy of PD-1 as neoadjuvant therapy resectable ESCC. We aim to assess safety and feasibility using combination chemotherapy Methods Patients previously untreated, (stage II or III) ESCC were enrolled. Each patient received two 21-day cycles treatment camrelizumab, nab-paclitaxel, carboplatin before undergoing...
Abstract Currently available guided bone regeneration (GBR) films lack active immunomodulation and sufficient osteogenic ability‐ in the treatment of periodontitis, leading to unsatisfactory outcomes. Challenges remain developing simple, rapid, programmable manufacturing methods for constructing bioactive GBR with tailored biofunctional compositions microstructures. Herein, controlled electroassembly collagen under salt effect is reported, which enables construction porous precisely tunable...
Oxidative stress plays a critical role in the pathophysiology of contrast-induced nephropathy (CIN). Since specific treatment CIN remains an unmet medical need, it is imperative to find effective strategy against clinical management CIN. The transcription factor Nrf2 known regulate antioxidative response. aim present study was assess effects tert -butylhydroquinone (t-BHQ), activator Nrf2, prevention and elucidate underlying mechanism its action vitro vivo . We established rat model treated...
Abstract Circular RNAs (circRNAs) have gained significant attention in recent years due to their diverse biological functions and potential as novel therapeutic modality. Two general mechanisms for generating circRNAs involve the utilization of group 1 2 introns, which are self-splicing ribozymes found many organisms. Although intron has been demonstrated be highly effective circularization, reaction requires high temperature plus cofactors such GTP. Consequently, undesired byproducts nicked...
Abstract Background Neoadjuvant chemotherapy followed by radical cystectomy (RC) is the standard of care for patients with muscle‐invasive bladder cancer (MIBC). However, treatment outcomes are suboptimal. Camrelizumab, a PD‐1 blockade, has shown benefits in several tumors. This study aimed to investigate efficacy and safety neoadjuvant camrelizumab combination gemcitabine plus cisplatin (GC) RC MIBC patients. Methods was multi‐center, single‐arm that enrolled clinical stage T2‐4aN0‐1M0,...
Branch atheromatous disease (BAD) makes patients prone to early neurological deterioration (END), resulting in poor prognosis. The aim of this study was investigate the association between SUA/SCr and END BAD stroke patients.We conducted a retrospective that included 241 with BAD-stroke within 48 h symptom onset. We divided into group no group. defined as an NIHSS score increase more than 2 points 1 week. calculated by concentration serum uric acid creatine (serum acid/serum creatine) on...
Thyroid hormones (THs) are primarily responsible for the regulation of energy homeostasis and metabolism. However, few prospective studies have assessed association between THs metabolic syndrome (MetS) in a general population. We therefore designed cohort study to examine whether serum TH levels within reference range predictive factors developing MetS adults.Prospective study.A (n = 6119) was performed Tianjin, China. Participants without history were followed up 1 3 years with median...
Objective. To explore the clinical value on combined detection of serum carbohydrate antigen 724 (CA724), secreted protein dickkopf-1 (DKK1), and thymidine kinase 1 (TK1) in diagnosis gastric cancer (GC). Methods. The data 63 GC patients (GC group) 54 with benign lesions (control admitted to Zhu Xianyi Memorial Hospital Tianjin Medical University from June 2020 2021 were retrospectively analyzed. levels CA724, DKK1, TK1 two groups detected by electrochemiluminescence instrument,...
Podocyte infolding glomerulopathy (PIG) is a newly recognized rare glomerular injury. The clinical significance and mechanism of this injury pattern remains unclear.We conducted retrospective study renal biopsies from January 2018 to December 2020 in Kingmed Diagnostics. biopsy features data were reviewed. Laser scanning microdissection mass spectrometry (LMD/MS) was analyze the potential mechanism.A total 116 (0.092%) out 126,086 diagnosed as PIG during period. Of these, 89 (76.7%) cases...
To date, genome-wide association studies (GWASs) have discovered 35 susceptible loci of leprosy; however, the cumulative effects these can only partially explain overall risk leprosy, and causal variants genes within remain unknown. Here, we conducted out new GWASs in two independent cohorts 5007 cases 4579 controls then a meta-analysis newly generated multiple previously published (2277 3159 controls) datasets were performed. Three novel 15 reported identified from datasets, increasing...
Background: It is clinically important to identify high-risk patients with acute coronary syndrome (ACS) who may require repeat revascularization. This retrospective study identified risk factors for revascularization among ACS after first-time successful percutaneous interventions (PCIs). The predictive value of the triglyceride high-density lipoprotein cholesterol (TG/HDL-C) ratio was also evaluated. Methods: We enrolled consecutive had angiography performed during period from 6 12 months...
Objective: To compare the efficacy and safety of combined treatment with thrombus aspiration intracoronary tirofiban in patients acute myocardial infarction (MI), elective percutaneous coronary intervention (PCI). Methods: Patients undergoing PCI during recovery from MI were randomized into two groups; group received tirofiban; control conventional PCI. Baseline clinical characteristics, postoperative blood flow (thrombolysis [TIMI] grade), TIMI perfusion (TMP) grade, no/slow reflow rate...
To provide appropriate surgical training guidance, some skill evaluation and safety detection methods have been developed. However, these are difficult to predictive information for trainees. This paper proposes a new approach real-time trajectory prediction of the laparoscopic instrument tip improve patient safety.This model based on long short-term memory (LSTM) neural network. Meanwhile, motion state is introduced capture more performance.The feasibility, effectiveness generalisation...
Abstract Background A training system that allows the trainee to perform laparoscopic suturing in a realistic environment and measures force applied tissue would be invaluable. This study aims establish construct content validity of we developed for objective assessment surgeons' skills. Methods Ten novices, 6 residents, experts performed knot‐tying task using system. force‐related parameters were used analyse system's validity. Experts invited evaluate with questionnaires. Results Eight...
Background: Bladder cancer is among the most lethal urinary system cancers across globe. Macrophage 1 and 2 play an essential role in pathogenesis of tumors. Nevertheless, prior studies failed to investigate implication two cells, working combination, development, growth, progression metastasis bladder cancer.   Methods: We computed M1/M2 ratio samples retrieved from The Cancer Genome Atlas (TCGA) by using Cibersortx algorithm calculated 32 patients our series...