A5065911650- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Liver physiology and pathology
- Hepatitis Viruses Studies and Epidemiology
- Diet, Metabolism, and Disease
- Pancreatic function and diabetes
- Vector-borne infectious diseases
- Viral Infections and Vectors
- Organ Transplantation Techniques and Outcomes
- Traditional Chinese Medicine Studies
- Rabies epidemiology and control
- Ultrasound and Hyperthermia Applications
- Mesenchymal stem cell research
- Gastrointestinal Bleeding Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Airway Management and Intubation Techniques
- Esophageal and GI Pathology
- Cerebrovascular and genetic disorders
- Abdominal vascular conditions and treatments
- Liver Diseases and Immunity
- Fungal Biology and Applications
- Garlic and Onion Studies
Tianjin Medical University
2011-2025
Tianjin Third Central Hospital
2011-2025
Hainan University
2024-2025
Tianjin University
2025
Shaanxi University of Chinese Medicine
2024
Nankai University
2024
Sun Yat-sen University
2023
Sun Yat-sen University Cancer Center
2023
Tianjin Hospital
2022
Tianjin Fire Research Institute
2022
•This is the first prospective validation of Baveno VII recompensation definition in patients with HBV-related cirrhosis.•A stable improvement liver function tests was defined as MELD <10 and/or ALB & INR TBIL within Child-Pugh A.•On-treatment scores may be more predictive probability than baseline scores.•Prompt antiviral therapy effective for cirrhosis, even under severe conditions. Background AimsAntiviral improves clinical outcomes chronic hepatitis B (CHB), including those cirrhosis. In...
Hepatic recompensation may be achieved in patients with decompensated cirrhosis due to chronic hepatitis B (CHB) upon effective suppression of viral replication by nucleos(t)ide analogues (NAs). However, the optimal timing and predictors subsequent clinical course CHB
Increased nut consumption has been associated with reduced inflammation, insulin resistance, and oxidative stress. Although these factors are closely involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), few studies have focused on association between NAFLD general population. We aimed to investigate an adult population.A total 23 915 participants from Tianjin Chronic Low-Grade Systemic Inflammation Health (TCLSIH) Cohort Study were included this study. Information...
Abstract Bile acids and salts have been shown to play a role in liver carcinogenesis through DNA damage, inflammation, tumor proliferation. However, the correlation between bile acid metabolism hepatocellular carcinoma (HCC) prognosis remains unclear. This study aimed identify predictive signature of salt metabolism-related long non-coding RNAs (lncRNAs) for HCC treatment response. The used RNA-sequencing data corresponding clinical prognostic from Cancer Genome Atlas. A model consisting...
Abstract Background/Objectives Many studies have suggested that probiotics may be applied as a therapeutic agent for non-alcoholic fatty liver disease (NAFLD). However, the effects of frequent yogurt consumption (as natural probiotic source) on NAFLD remain poorly understood. This study was to examine association habitual with newly diagnosed in general adult population. Subject/Methods Overall, 24,389 adults were included this cross-sectional study. Yogurt estimated by using validated...
The protective effect of garlic against nonalcoholic fatty liver disease (NAFLD) has been reported in animal studies. However, humans, the association between consumption and NAFLD is unclear. study sought to explore habitual raw intake newly diagnosed among Chinese adults.We performed a 11,326 men 12,780 women aged 20-90 years. Habitual food was assessed using validated standardized 100-item frequency questionnaire. Diagnosis based on ultrasonography self-reported alcohol intake. Multiple...
Background Tislelizumab is an anti-programmed cell death 1 (PD-1) monoclonal antibody engineered to minimize binding Fcγ receptors. It has been used treat several solid tumors. However, its efficacy and toxicity, the predictive prognostic value of baseline hematological parameters in patients with recurrent or metastatic cervical cancer (R/M CC) receiving tislelizumab remain unclear. Methods We reviewed 115 treated for R/M CC from March 2020 June 2022 our institute. The antitumor activity...
Data on safety and immunogenicity of coronavirus disease 2019 (COVID-19) vaccinations in hepatocellular carcinoma (HCC) patients are limited. In this multicenter prospective study, HCC received two doses inactivated whole-virion COVID-19 vaccines. The neutralizing antibody were monitored. Totally, 74 enrolled from 10 centers China, 37 (50.0%), 25 (33.8%), 12 (16.2%) the CoronaVac, BBIBP-CorV, WIBP-CorV, respectively. vaccines well tolerated, where pain at injection site (6.8% [5/74])...
Emergency endoscopy is recommended for patients with acute esophageal variceal bleeding (EVB) and their prognosis has improved markedly over past decades due to the increased specialization of endoscopic practice. The study aimed compare outcomes following emergency injection sclerotherapy (EIS) ligation (EVL) in cirrhotic EVB.Cirrhotic EVB who underwent were retrospectively enrolled from 2013 2020 across 34 university hospitals 30 cities. primary outcome was incidence 5-day rebleeding after...
Abstract Aim To determine the tolerance and acceptance of hepatic venous pressure gradient (HVPG) measurements in patients with liver cirrhosis. Methods This prospective international multicenter study included 271 cirrhosis who were scheduled to undergo HVPG measurement between October 2019 June 2020. Data related collected using descriptive questionnaires. Results technically successful all patients, 141 (52.0%) undergoing alone. The complication rate was 0.4%. Postoperative pain...
Abstract Aims The endoscopic treatment of esophagogastric varices is challenging, and the nationwide application therapies for various types different clinical scenarios remains unclear. This study investigated use therapy portal hypertension in China. Methods used a questionnaire survey initiated by Liver Health Consortium China to investigate hypertension. Questionnaires were released online from January 30, 2023 February 28, filled out chief physicians or senior instructors responsible...
To investigate the clinical value of FibroScan transient elastography for assessing portal hypertension in liver cirrhosis patients by determining relationship between or spleen stiffness measurement with imaging parameters esophageal varices, vein width, volume, and splenic width.A total 259 underwent measurement, ultrasound, computed tomography routine blood analyses. One-hundred-and-one those also endoscopy to diagnose varices. Receiver operating characteristic (ROC) curves were generated...
Objective: To analyze the occurrence of recompensation conditions in patients with chronic hepatitis B virus-related decompensated cirrhosis after entecavir antiviral therapy. Methods: Patients ascites as initial manifestation were prospectively enrolled. who received treatment for 120 weeks and followed up every 24 (including clinical endpoint events, hematological imaging indicators, others) calculated rates according to Baveno VII criteria. Measurement data compared using Student t-test...
Cytokines/chemokines play essential roles in the occurrence and progression of hepatitis B virus (HBV) infection. This study aimed to observe expression patterns 10 related cytokines/chemokines serum healthy individuals, self-limited patients HBV-infected at different stages disease (chronic (CHB), liver cirrhosis (LC), hepatocellular dysplastic nodules (DNs) carcinoma (HCC)) analyze relationships these with progression.
e16181 Background: Primary liver cancer is a major health burden globally, ranking sixth in incidence and third mortality among all cancers[1]. Over the past 5 years, immune checkpoint inhibitors (ICIs) multi-targeted tyrosine-kinase have emerged as new treatment options for advanced hepatocellular carcinoma[2–4]. Nevertheless, only small subset of patients with carcinoma derive response to ICI monotherapy. Icaritin, target tumor micro-environment(TME) modulating compound, which interacts...