A5101491473- Extracellular vesicles in disease
- Graphene research and applications
- Quantum and electron transport phenomena
- Acute Myocardial Infarction Research
- RNA modifications and cancer
- Topological Materials and Phenomena
- Cardiac Imaging and Diagnostics
- MicroRNA in disease regulation
- Antiplatelet Therapy and Cardiovascular Diseases
- Circular RNAs in diseases
- 2D Materials and Applications
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Optical Systems and Laser Technology
- Diamond and Carbon-based Materials Research
- Catalytic Processes in Materials Science
- Cancer-related molecular mechanisms research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Heart Failure Treatment and Management
- Immune Response and Inflammation
- Gut microbiota and health
- Cardiac Ischemia and Reperfusion
- Immune cells in cancer
- Plasmonic and Surface Plasmon Research
- Perovskite Materials and Applications
University of California, Berkeley
2020-2024
First Affiliated Hospital of Henan University of Science and Technology
2008-2023
Peking University
2016-2023
Sichuan University
2023
Chinese PLA General Hospital
2020-2022
Hangzhou Dianzi University
2022
Ocean University of China
2022
Tianjin Medical University
2008-2021
Sichuan Cancer Hospital
2016-2018
University of Electronic Science and Technology of China
2017-2018
Hypoxia is a common feature of solid tumors and associated with aggressiveness poor patient outcomes. Exosomes, initially considered to be cellular "garbage dumpsters," are now implicated in mediating interactions the environment. However, mechanisms underlying association between exosomes hypoxia during cancer progression remain poorly understood. In this study, we found that derived from hypoxic oral squamous cell carcinoma (OSCC) cells increased migration invasion OSCC HIF-1α...
In this study, we sought to investigate the potential application of γδ T cell-derived extracellular vesicles (γδTDEs) as drug delivery system (DDS) for miR-138 in treatment oral squamous cell carcinoma (OSCC). Our data showed that overexpression cells obtained miR-138-rich γδTDEs accompanying increased expansion and cytotoxicity cells. inherited cytotoxic profile could efficiently deliver OSCC cells, resulting synergetic inhibition on both vitro vivo. The pre-immunization by inhibited...
CUEDC2, a CUE-domain-containing protein, modulates inflammation, but its involvement in tumorigenesis is still poorly understood. Here, we report that CUEDC2 key regulator of macrophage function and critical for protection against colitis-associated tumorigenesis. expression dramatically upregulated during differentiation, deficiency results excessive production proinflammatory cytokines. The level macrophages modulated by miR- 324-5p. We find Cuedc2 KO mice are more susceptible to...
The flat bands resulting from moiré superlattices exhibit fascinating correlated electron phenomena such as insulators, ( Nature 2018, 556 (7699), 80-84), Physics 2019, 15 (3), 237) superconductivity, 43-50), 572 (7768), 215-219) and orbital magnetism. Science 365 (6453), 605-608), 2020, 579 (7797), 56-61), 367 (6480), 900-903) Such magnetism has been observed only at particular integer multiples of n0, the density corresponding to one per superlattice unit cell. Here, we report experimental...
Cancer stem cells (CSCs) play significant roles in cancer development, drug resistance and recurrence. In treatments based on the CSC characteristics inducing factors, MYC is a promising target for therapeutic molecules. Although it has been regarded as an undrugable target, its stability tightly regulated by ubiquitin-proteasome system offers new direction molecule targeting treatment. Herein we report our discoveries this research area, have found that deubiquitinase USP45 can directly...
ABC-stacked trilayer graphene on boron nitride (ABC-TLG/hBN) moiré superlattices provides a tunable platform for exploring Wigner crystal states in which the electron correlation can be controlled by electric and magnetic fields. Here we report observation of field-stabilized ABC-TLG/hBN. We show that correlated insulating emerge at multiple fractional integer fillings corresponding to ν = 1/3, 2/3, 1, 4/3, 5/3, 2 electrons per lattice site under field. These attributed generalized Mott...
Engineering the properties of materials is central importance in modern science and technology. In conventional bulk materials, property changes are realized mainly through modifying chemical bonds crystalline structures, or introducing dopant atoms. Recent studies van der Waals coupled 2D layered have demonstrated a different way engineering interlayer interactions at material interfaces, because these can be easily controlled by changing stacking configurations and/or applying external...
Moiré superlattices, constituted by two-dimensional materials, demonstrate a variety of strongly correlated and topological phenomena including insulators, superconductivity, integer/fractional Chern insulators. In the realm nontrivial insulators within specific moiré previous studies usually observe single number at given filling factor in device. Here we present observation gate-tunable numbers insulator state an ABC-stacked trilayer graphene/hexagonal boron nitride superlattice Near...
To investigate the impact of cardiologist-coordinated intensive follow-up on long-term prognosis percutaneous coronary intervention in Chinese patients. We recruited 964 patients who had acute syndrome and underwent successful First Hospital Affiliated to Henan University Science Technology, China. Participants were randomly assigned into (n = 479) usual group (control group, n 485). They received secondary prevention education during hospitalization telephone follow-ups after discharge. The...
This study investigated the relationship among β-cell function, metabolic control, and diabetic microvascular complications in patients with type 2 diabetes mellitus (T2DM).In total, 885 (DM) were recruited from January 2012 to 2014 grouped into three groups according area under curve of C-peptide [AUC(C-pep)] during 75-g oral glucose tolerance test. Logistic regression analyses used evaluate association between complications.The prevalence decreased first third AUC(C-pep) tertile (P < 0.01...
Porphyromonas gingivalis (Pg) is one of the keystone pathogens involved in periodontitis. The present study aimed to observe relationship among different infection forms Pg, systemic inflammation, and acute myocardial infarction (AMI).A total 382 patients diagnosed with AMI 78 without coronary heart disease (CHD) were included study. DNA from exfoliated oral cells, circulating cell-free (cfDNA), genomic (gDNA) blood samples extracted. qPCR method was employed detect Pg infection. Clinical...
Background Although the insulinotropic role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes mellitus has been substantiated, its cardioprotection remains largely unknown. This study aimed to determine effects GLP-1 on injury rats cardiac myocytes induced by hypoxia-reoxygenation (H/R) and possible mechanisms. Methods The cultured neonatal were randomly divided into seven groups: normal control group, H/R GLP-1+H/R GLP-1+H/R+UO126 (the p42/44 mitogen-activated protein kinase (MAPK)...