A5101522849- Renal Diseases and Glomerulopathies
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Acute Kidney Injury Research
- Gout, Hyperuricemia, Uric Acid
- Diabetes Management and Research
- Cytomegalovirus and herpesvirus research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Epilepsy research and treatment
- Renal Transplantation Outcomes and Treatments
- Extracellular vesicles in disease
- Chronic Kidney Disease and Diabetes
- Pharmacological Effects and Toxicity Studies
- Pharmacological Receptor Mechanisms and Effects
- Genomics, phytochemicals, and oxidative stress
- Atherosclerosis and Cardiovascular Diseases
- Liver Disease and Transplantation
- FOXO transcription factor regulation
- Bone and Joint Diseases
- Intensive Care Unit Cognitive Disorders
- Organ Transplantation Techniques and Outcomes
- Genetics, Aging, and Longevity in Model Organisms
- Inflammatory Biomarkers in Disease Prognosis
- Dementia and Cognitive Impairment Research
Northeast Agricultural University
2023-2025
Third Affiliated Hospital of Southern Medical University
2016-2023
Central South University
2022-2023
Second Xiangya Hospital of Central South University
2022-2023
Zhejiang Center for Disease Control and Prevention
2022
Zhejiang University
2022
Shanghai Clinical Research Center
2022
First Affiliated Hospital Zhejiang University
2022
Xinjiang Medical University
2021
Beijing University of Chinese Medicine
2020
In Brief Objective: This study aimed to describe the implementation of preoperative geriatric assessment (GA) in patients undergoing major cancer surgery and determine predictors postoperative delirium. Background: Geriatric surgical have unique vulnerabilities are at increased risk developing Methods: Geriatricians Memorial Sloan Kettering Cancer Center risk-stratify with solid tumors, ages 75 years older, using GA, which includes basic instrumental activities daily living (ADLs, IADLs),...
Background . Oxidative stress plays an important role in the pathogenesis of contrast‐induced nephropathy (CIN). The aim this study was to investigate antioxidant effects sulforaphane (SFN) a rat model CIN and cell oxidative HK2 cells. Methods Rats were randomized into four groups ( n = 6 per group): control group, Ioversol group (Ioversol‐induced CIN), + SFN (CIN rats pretreated with SFN), (rats treated SFN). Renal function tests, malondialdehyde (MDA), reactive oxygen species (ROS)...
Oxidative stress plays a critical role in the pathophysiology of contrast-induced nephropathy (CIN). Since specific treatment CIN remains an unmet medical need, it is imperative to find effective strategy against clinical management CIN. The transcription factor Nrf2 known regulate antioxidative response. aim present study was assess effects tert -butylhydroquinone (t-BHQ), activator Nrf2, prevention and elucidate underlying mechanism its action vitro vivo . We established rat model treated...
<b><i>Background/Aims:</i></b> Chronic renal allograft dysfunction (CRAD) is a leading cause of long-term loss. Oxidative stress may account for the nonspecific interstitial fibrosis and tubular atrophy that occur in CRAD. An antioxidant intervention <i>via</i> Nrf2 signaling pathway activation might be promising therapy some kidney diseases. The present paper investigates whether there an association between oxidative alleviation sulforaphane-induced...
Hyperuricemia is an independent risk factor for renal damage and can promote the progression of chronic kidney disease (CKD). In present study, we employ a rat model to investigate effects rosiglitazone (RGTZ), peroxisome proliferator-activated receptor-gamma agonist, on development hyperuricemic nephropathy (HN), elucidate mechanisms involved.An HN was established by oral administration mixture adenine potassium oxonate daily 3 weeks. Twenty-four rats were divided into 4 groups: sham...
Acute kidney injury (AKI) is in high prevalence the world. However, therapeutic strategies for AKI are still mystery. Studies have shown to improve autophagy and lysosomal function could inhibit AKI. But their modulators need be explored detail. Annexin A2 (ANXA2) a phospholipid-binding protein involving organelle membrane integrity function, suggesting its important role lysosome homeostasis. It implicates ANXA2 potentially protects against this has not been elucidated. Herein, we found...
Current evidence shows that apolipoprotein E (APOE), CI (APOC1) and low density lipoprotein receptor-related protein (LRP) variations are related to late-onset Alzheimer's disease. However, it remains unclear if genetic polymorphisms in these genes associated with cognitive decline disease patients. We performed a 30-month longitudinal cohort study investigate the relationship between APOE, APOC1, LRP. In this study, 78 Chinese Han patients were recruited form Guangxi Zhuang Autonomous...
High-density lipoprotein (HDL) particles comprising heterogeneous subclasses of different functions exert anti-inflammatory effects by interacting with immune-response cells. However, the relationship HDL cells in metabolic unhealth/obesity has not been defined clearly. The purpose this study was to delineate relational changes immune and inflammatory markers understand role subclasses. A total 316 participants were classified health. detected microfluidic chip electrophoresis. White blood...
Glycemic variability (GV) in some patients with type 1 diabetes (T1D) remains heterogeneous despite comparable clinical indicators, and whether other factors are involved is yet unknown. Metabolites the serum indicate a broad effect of GV on cellular metabolism therefore more likely to metabolic dysregulation associated T1D. To compare metabolomic profiles between high (GV-H, coefficient variation (CV) glucose ≥ 36%) low (GV-L, CV < groups identify potential biomarkers, metabolomics...
Objective Adiponectin receptor 1 (encoded by ADIPOR1) is one of the major adiponectin receptors, and plays an important role in glucose lipid metabolism. However, few studies have reported simultaneous associations between ADIPOR1 variants type 2 diabetes (T2D), coronary artery disease (CAD) T2D with CAD. Based on "common soil" hypothesis, we investigated whether polymorphisms contributed to etiology T2D, CAD, or CAD a Northern Han Chinese population. Methods Our multi-disease comparison...
Diabetic kidney disease (DKD), which is related to inflammation and immune response, the primary vascular complication of diabetes mellitus also leading etiology end-stage renal disease. Urinary extracellular vesicles (UEVs) are an attractive source for biomarker detection as they involve molecular constituents derived from their parental sections nephron. In this study, we aimed search a potential in UEVs early diagnosis prediction DKD, especially before emergence microalbuminuria.UEVs were...
To determine the effect of gut microbiota on a rat model post-traumatic stress disorder (PTSD) and explore correlation with behavior neurotransmitters. We established single prolonged (SPS) to examine pathogenesis PTSD behavior, microbiota, neurotransmitter levels. Rats were separated into control groups, levels measured using enzyme linked immunosorbent assay. Then, 16 S rRNA sequencing was used compare between groups. Compared those in group, freezing time significantly increased, while...
Hyperuricemia is an independent risk factor for renal damage and promotes the progression of chronic kidney disease. In this study, we investigated effect I-BET151, a small-molecule inhibitor targeting bromodomain extraterminal (BET) proteins, on development hyperuricemic nephropathy (HN), mechanisms involved. Expression levels bromodomain-containing protein 2 4, but not 3 were increased in rats with HN; administration I-BET151 effectively prevented dysfunction, decreased urine microalbumin,...
Abstract Aims To investigate glycaemic variability (GV) patterns in patients with type 1 diabetes (T1D), 2 (T2D), and latent autoimmune adults (LADA). Materials Methods A total of 842 subjects (510 T1D, 105 LADA, 227 T2D) were enrolled underwent week continuous glucose monitoring (CGM). Clinical characteristics CGM parameters compared among T2D. LADA divided into two subgroups based on glutamic acid decarboxylase autoantibody titres (≥180 U/mL [LADA‐1], <180 [LADA‐2]) compared. The...
Chronic renal allograft dysfunction (CRAD) is the primary factor affecting long-term survival of patients who have undergone transplantation. Oxidative stress and inflammation serve an important role in pathological damage caused by CRAD early post-transplantation phase. Previous studies demonstrated that sirtuin 3 (sirt3) protects cells from oxidative inflammation. A model orthotopic transplantation was established current study kidney samples were harvested rats 12 weeks following surgery....
Independent of their lipid-lowering effects, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors have renal protective effects on various models progressive diseases, therefore, additional therapeutic advantages been considered. In the present study, using spontaneously hypercholesterolaemic Imai rats, we examined pitavastatin injuries and oxidative modification low-density lipoprotein (LDL) high-density (HDL), since oxidized lipoproteins are speculated to be involved in...