A5030427552- Asymmetric Hydrogenation and Catalysis
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Crystallization and Solubility Studies
- Synthesis and Catalytic Reactions
- Atherosclerosis and Cardiovascular Diseases
- Vascular anomalies and interventions
- Myasthenia Gravis and Thymoma
- Adipose Tissue and Metabolism
- Curcumin's Biomedical Applications
- Natural Antidiabetic Agents Studies
- Whipple's Disease and Interleukins
- Advanced Nanomaterials in Catalysis
- Systemic Lupus Erythematosus Research
- Cancer Research and Treatment
- Protein Tyrosine Phosphatases
- Systemic Sclerosis and Related Diseases
- Renal Diseases and Glomerulopathies
- Meningioma and schwannoma management
- Central Venous Catheters and Hemodialysis
- Pituitary Gland Disorders and Treatments
- Diabetes and associated disorders
- Pomegranate: compositions and health benefits
- Chronic Kidney Disease and Diabetes
- Autophagy in Disease and Therapy
Sun Yat-sen University
2021-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2021-2024
First Affiliated Hospital of Zhengzhou University
2023
Philipps University of Marburg
2018-2023
Yellow River Institute of Hydraulic Research
2015
By combining a chiral-at-metal ruthenium catalyst with catalytic amounts of tris(<italic>p</italic>-fluorophenyl)phosphine (both 1 mol%), the challenging enantioselective ring-closing C(sp<sup>3</sup>)-H amination unactivated aliphatic azides has been achieved high enantioselectivities.
The aggressive phenotype of fibroblast-like synoviocytes (FLSs) is essential in the synovitis and bone destruction rheumatoid arthritis (RA). Punicalagin a natural polyphenol extracted pomegranate juice, which possesses antioxidant, anti-inflammatory anti-tumor properties suggesting it may be potent drug for RA therapy. However, there paucity information on its effect RA.To investigate effects punicalagin synovial inflammation RA.FLSs were isolated from tissue patients. mRNA levels evaluated...
Abstract Acute kidney injury (AKI) is a common disease associated with excessive reactive oxygen species (ROS). Unfortunately, due to the low targeting and undesired side effects, existing antioxidant anti-inflammatory drugs are unavailable for AKI management in clinic. Therefore, it’s essential develop effective nanodrugs high renal biocompatibility treatment. Herein, we reported novel nanodrug treatment, utilizing poly(ursolic acid) (PUA) as bioactive nanocarrier resveratrol (RES) model...
This study demonstrates that chiral-at-iron complexes, in which all coordinated ligands are achiral and the overall chirality consequence of a stereogenic iron center, capable catalyzing asymmetric transformations with very high enantioselectivities. The catalyst is based on previously reported design (J. Am. Chem. Soc. 2017, 139, 4322), iron(II) surrounded by two configurationally inert bidentate N-(2-pyridyl)-substituted N-heterocyclic carbenes C2-symmetric fashion complemented labile...
The origin of enantioselectivity in the asymmetric alkynylation trihalomethyl ketones catalyzed by octahedral stereogenic-at-ruthenium complexes has been investigated through density functional theory calculations. Computational results support a mechanism involving formation ruthenium acetylide, followed pre-coordination ketone carbonyl oxygen and intramolecular attack acetylide via compact four-membered transition state. Differences computed free energies activation for major minor...
Comprehensive Summary Enantioselective or enantioconvergent iron‐catalyzed ring‐closing C(sp 3 )‐H aminations of N ‐aroyloxyurea through intermediate iron nitrene species provide chiral 2‐imidazolidinones in up to 99% yield and with 95% ee (40 examples). This is a rare example which sustainable catalysis combined amination asymmetric catalysis. Chiral are prevalent structural motifs bioactive molecules can also be hydrolyzed valuable vicinal diamines single step.
Podocyte infolding glomerulopathy (PIG) is a newly recognized rare glomerular injury. The clinical significance and mechanism of this injury pattern remains unclear.We conducted retrospective study renal biopsies from January 2018 to December 2020 in Kingmed Diagnostics. biopsy features data were reviewed. Laser scanning microdissection mass spectrometry (LMD/MS) was analyze the potential mechanism.A total 116 (0.092%) out 126,086 diagnosed as PIG during period. Of these, 89 (76.7%) cases...
A sterically demanding derivative of a previously introduced chiral‐at‐metal ruthenium(II) catalyst scaffold is introduced. It composed two bidentate furo[3,2‐ b ]pyridyl functionalized N‐heterocyclic carbene ligands. Their cis ‐coordination generates helical chirality and stereogenic ruthenium center. Two additional labile acetonitriles compose the catalytic site which highly shielded by 2‐( tert ‐butyl)furo[3,2‐ ]pyridine moieties. The synthesis non‐racemic its properties for...
To describe an alternative arteriovenous fistula (AVF) model involving anastomosis of the common carotid artery (CCA) with posterior facial vein (PFV).
The secondary suspended river in the lower of Yellow River has been developing seriously, Possibility floods running along main dike toe parts reach, even "rolling flow" maybe appear, security threaten greatly.To solve problem river, key method is to reduce elevation difference between channel and dike.The control measure extracting sands from beach "dike river", which means dike, by adopting machines.In this paper, using 2-D hydrodynamic mathematical model analyze change flow velocity after...
Background The aim of this study was to assess the impact preoperative chemotherapy on long-term survival (≥1 month) in patients with thymic epithelial tumors (TETs) and conditions suitable for using data from surveillance, epidemiology, end-result databases. Methods This retrospective controlled confounding factors by propensity score matching (PSM), analyzed overall (OS) cancer-specific (CSS) Kaplan-Meier methods, affecting prognosis undergoing surgery univariate multifactorial Cox...