A5100405014- Advanced Radiotherapy Techniques
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Respiratory Support and Mechanisms
- Anesthesia and Pain Management
- Obstructive Sleep Apnea Research
- Occupational and environmental lung diseases
- Endometrial and Cervical Cancer Treatments
- Lung Cancer Treatments and Mutations
- Traditional Chinese Medicine Analysis
- Nitric Oxide and Endothelin Effects
- Head and Neck Cancer Studies
- Brain Metastases and Treatment
- Neuroscience of respiration and sleep
- Gestational Diabetes Research and Management
- Traditional Chinese Medicine Studies
- Gastric Cancer Management and Outcomes
- Effects of Radiation Exposure
- Lung Cancer Diagnosis and Treatment
- Obesity, Physical Activity, Diet
- Nausea and vomiting management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ovarian cancer diagnosis and treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pain Mechanisms and Treatments
National Taiwan University
2015-2025
China Medical University
2025
The First People's Hospital of Changzhou
2024-2025
Soochow University
2015-2025
National Taiwan University Hospital
2013-2025
Mudanjiang Medical University
2025
Nanjing Medical University
2025
Jiangsu Province Hospital
2025
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2024
Beijing University of Chinese Medicine
2020-2024
Abstract Background and Purpose. Patients requiring prolonged mechanical ventilation (PMV) are frequently deconditioned because of respiratory failure precipitated by the underlying disease, adverse effects medications, a period immobilization. The 6 weeks physical training on strength limb muscles, ventilator-free time, functional status in patients PMV were examined. Subjects. Thirty-nine with initially enrolled study assigned to either treatment group (n=20) or control (n=19). Three...
To strengthen the effectiveness of resveratrol (RES) as a natural antioxidant in food systems, this work attempted to enhance water solubility RES by utilizing solubilizing properties stevioside (STE) and investigated effect STE-solubilized (STE-RES) incorporation on stability soy protein isolate (SPI)-based emulsions. The physical oxidative SPI emulsions with STE/STE-RES were evaluated. increased increase STE concentration up its critical micelle concentration, suggesting solubilization...
ABSTRACT Cytochrome-to-cytochrome electron transfer and along conduits of multiple extracellular magnetite grains are often proposed as strategies for direct interspecies (DIET) that do not require electrically conductive pili (e-pili). However, physical evidence these DIET mechanisms has been lacking. To investigate possibilities further, we constructed Geobacter metallireducens strain Aro-5, in which the wild-type pilin gene was replaced with aro-5 previously shown to yield poorly...
Lung cancer and pleural mesothelioma are two of the most deadly forms cancer. The prognosis lung is extremely poor due to limited treatment modalities lack understanding disease mechanisms. We have identified mesothelin as a potentially unique therapeutic target that specific advantage appears nonessential in cell types. Mesothelin (MSLN), plasma membrane differentiation antigen, expressed at high level many human solid tumors, including 70% nearly all mesotheliomas. However, role MSLN...
A highly efficient photoenergy conversion is strongly dependent on the cumulative cascade efficiency of photogenerated carriers. Spatial heterojunctions are critical to directed charge transfer and, thus, attractive but still a challenge. Here, spatially ternary titanium-defected TiO2@carbon quantum dots@reduced graphene oxide (denoted as VTi@CQDs@rGO) in one system shown demonstrate effect charges and significant performances regarding photocurrent, apparent yield, photocatalysis such H2...
Upon myocardial infarction (MI), activated cardiac fibroblasts (CFs) begin to remodel the myocardium, leading fibrosis and even heart failure. No therapeutic approaches are currently available prevent development of MI-induced pathological fibrosis. Most pharmacological trials fail from poor local drug activity side effects caused by systemic toxicity, largely due lack a heart-targeted delivery system that is selective for CFs. Here, we developed reduced glutathione (GSH)-responsive...
Ferroptosis is an alternative strategy to overcome chemoresistance, but effective therapeutic approaches induce ferroptosis for acute myeloid leukemia (AML) treatment are limited. Here, we developed glutathione (GSH)-responsive cysteine polymer-based ferroptosis-inducing nanomedicine (GCFN) as efficient inducer and chemotherapeutic drug nanocarrier AML treatment. GCFN depleted intracellular GSH inhibited peroxidase 4, a GSH-dependent hydroperoxidase, cause lipid peroxidation in cells....
Whole brain radiotherapy (WBRT), stereotactic radiosurgery (SRS), and the combination of both treatment methods were used for management single metastasis from lung cancer. The purpose this study is to compare these three different options in terms local response, survival, quality life. From June 1995 July 1998, 70 cancer patients with new diagnosed treated either WBRT alone (n = 29), or SRS 23), 18). Multiple endpoints, including freedom progression (FFLP), (FFNBM), control, Karnofsky...
Abstract Cisplatin is a potent cytotoxic agent commonly used for the treatment of solid tumors. However, tumor cell–acquired resistance to cisplatin-induced apoptosis major limitation efficient therapy, as frequently observed in human lung cancer. Nitric oxide (NO) key regulator apoptosis, but its role cell death and underlying mechanism are largely unknown. Previous studies indicate increased NO synthase activity elevated production carcinomas, which correlate with incidence...
<b><i>Background:</i></b> Numerous studies have reported the relationship between sleep duration and obesity in elderly adults; however, little is known about of sarcopenia. <b><i>Objective:</i></b> We examined with sarcopenia community-dwelling older adults. <b><i>Methods:</i></b> A total 488 adults (224 men 264 women) aged ≥65 years were included analysis. Self-reported anthropometric data collected. Skeletal muscle...
We aimed (1) to investigate the effect of a 12-week exercise training on sleep quality and heart rate variability in middle-aged older adults with poor (2) examine factors associated improvements parameters.Forty aged ≥ 40 years (mean age = 62 years; 82.5% female) participated this study. They were randomized into group or control group. Each program consisted minutes supervised aerobic 10 stretching class, 3 times week for 12 weeks. Outcome measures included both subjective (Pittsburgh...
Accumulating evidence indicates that carbon nanotubes (CNTs) are biopersistent and can cause lung damage. With similar fibrous morphology mode of exposure to asbestos, a known human carcinogen, growing concern has arisen for elevated risk CNT-induced carcinogenesis; however, relatively little is about the long-term carcinogenic effect CNT. Neoplastic transformation key early event leading carcinogenesis. We studied ability single- multi-walled CNTs induce neoplastic epithelial cells compared...
Relatively little is known about the fate of industrially relevant engineered nanomaterials (ENMs) in lungs that can be used to convert administered doses delivered doses. Inhalation exposure and subsequent translocation ENMs across epithelial lining layer lung might contribute clearance, toxic effects or both. To allow precise quantitation cells, we developed a method for tracking metal oxide vitro using neutron activation. The versatility sensitivity proposed (INVET) system was...
Nausea and vomiting are among the most common distressing side effects of chemotherapy. Additional antiemetic drugs urgently needed to effectively manage ameliorate chemotherapy-induced nausea (CINV). The efficacy ginger as an modality for ameliorating CINV has not been established in previous studies. aim this study was examine ginger, adjuvant drug standard therapy, acute delayed patients with lung cancer receiving cisplatin-based regimens. In randomized, double-blind, placebo-controlled...
Extubation failure can lead to a longer intensive care unit (ICU) stay, higher mortality rate, and risk of requiring tracheostomy. Chest physiotherapy (CPT) help patients in reducing the accumulation airway secretion, preventing collapsed lung, improving lung compliance, comorbidities. Much research has investigated correlation between CPT respiratory system clearance. However, few studies have failed ventilator extubation. Therefore, this study aimed investigate use for rate removal from...
This study was designed to explore the impact of Lycium barbarum polysaccharide (LBP) on inflammation and gut microbiota in mice with allergic asthma. Mice were divided into four groups: control group, OVA (ovalbumin) Con+LBP OVA+LBP group. After 28 days LBP intervention, euthanized associated indications investigated. Histopathological examination demonstrated that reduced lung injury. The results our current provide evidence supplementation asthmatic decreases TNF, IL-4, IL-6, MCP-1,...
Abstract Acute kidney injury (AKI) is a common disease associated with excessive reactive oxygen species (ROS). Unfortunately, due to the low targeting and undesired side effects, existing antioxidant anti-inflammatory drugs are unavailable for AKI management in clinic. Therefore, it’s essential develop effective nanodrugs high renal biocompatibility treatment. Herein, we reported novel nanodrug treatment, utilizing poly(ursolic acid) (PUA) as bioactive nanocarrier resveratrol (RES) model...