A5012380108- Skin Protection and Aging
- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- Immune Cell Function and Interaction
- Plant and Fungal Species Descriptions
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- melanin and skin pigmentation
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Cancer-related gene regulation
- Plant Stress Responses and Tolerance
- Cancer Immunotherapy and Biomarkers
- Aluminum toxicity and tolerance in plants and animals
- Gastric Cancer Management and Outcomes
- Multiple Myeloma Research and Treatments
- Pharmacological Effects of Natural Compounds
- Plant Pathogens and Fungal Diseases
- Esophageal Cancer Research and Treatment
- Fungal and yeast genetics research
- Metastasis and carcinoma case studies
- Plant Micronutrient Interactions and Effects
- Autophagy in Disease and Therapy
- Biochemical Analysis and Sensing Techniques
- MicroRNA in disease regulation
Research Institute of Forestry
2022-2024
Chinese Academy of Forestry
2022-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2017-2024
Nanjing University of Chinese Medicine
2021-2024
First Affiliated Hospital of Wenzhou Medical University
2024
Nanjing Forestry University
2021-2024
China Southern Power Grid (China)
2024
Shandong University
2022-2024
Shanxi Medical University
2024
Institute of Mental Health
2024
The CRISPR/Cas9 technology is being employed as a convenient tool for genetic engineering of the industrially important filamentous fungus Trichoderma reesei. However, multiplex gene editing still constrained by sgRNA processing capability, hindering strain improvement T. reesei production lignocellulose-degrading enzymes and recombinant proteins.
Toll-like receptors (TLRs) are known to recognize not only pathogen-associated molecular patterns but also danger‑associated patterns. Recent studies have characterized the expression levels and functions of TLRs in human epidermal cells. However, characteristics TLR family members dermal fibroblasts been thoroughly studied. Therefore, present study systematically investigated their functional responses each ligand skin fibroblasts. All 10 expressed Stimulation with resulted an increase...
Harmful cyanobacterial blooms occur worldwide and pose a great threat to aquatic ecosystems public health. The application of algicidal bacteria represents an eco-friendly strategy for controlling harmful blooms; thus, searching high efficiency has been becoming important continuous task in science. Herein, we identified bacterial strain coded Streptomyces sp. HY with highly activity, investigated its mechanism against Microcystis aeruginosa. displayed activity toward aeruginosa cells,...
Abstract Background In recent years, the role of altered cellular metabolism in tumor progression has attracted widespread attention. Related metabolic enzymes have also been considered as potential cancer therapeutic targets. Serine hydroxymethyltransferase 2 (SHMT2) reported to be upregulated several cancers and associated with poor prognosis. However, there are few studies SHMT2 esophageal (EC), related functions mechanisms need further explored. Methods this study, we first analyzed...
Background Plasma D-dimer levels have been shown to be high in advanced tumor stage patients and can used predict clinical outcome cancer patients. As most exhibit asymptomatic metastasis, which contributes early recurrence after surgery, we hypothesized that plasma with potential metastasis. Methods We enrolled 1042 primary gastric three multiple centers Northwest China examined using the latex-enhanced immunoturbidimetric assay (LEIA) method. were compared clinicopathological...
Lonicera japonica Thunb (LJT) is a commonly used herbal soup to treat inflammation-related diseases. However, the effect of LJT on ALI unknown. The present study was aimed at investigating protective effects extract (LTE) and its active ingredient luteolin (Lut) lipopolysaccharide (LPS)-stimulated investigate potential mechanism.The LTE Lut were explored in an mouse model induced by intraperitoneal injection (LPS). Besides, LPS-induced inflammation BEAS-2B cells clarify underlying...
Abstract Background There has been little research on the perioperative D‐dimer levels in oesophageal cancer patients. Plasma can be used to predict outcome Methods A group of 66 patients and a control 12 with benign disease were enrolled this cohort study. The plasma during pre‐operation 3rd 9th day post‐operation periods prospectively examined analysed between two groups. also compared clinicopathological characteristics 3‐year survival Results increased both groups after surgery, but they...
Fibrinogen (FIB) is an important source of fibrin, which plays a crucial role in circulating tumor cells (CTCs) extravasation and distant metastasis development. We hypothesize it's stable final product, plasma D-dimer, may be associated with CTCs appearance can reflect the metastatic phenotype cancer patients. first verified our hypothesis different murine gastric models vivo, D-dimer fibrinogen as well its degradation products were directly examined three immune-deficient mouse controls....
The benefits of inhibiting autophagy in cancer are still controversial, with differences outcome based on the type tumor, context and particular stage inhibition. Here, we investigated impact at different stages chemosensitivity using 3‐dimensional (3D) models mesothelioma, including ex vivo human tumor fragment spheroids. As shown by LC3B accumulation, successfully inhibited either an early ULK1/2 inhibitor (MRT 68921) or a late (hydroxychloroquine). We found that inhibition stage, but not...
The Wnt/β-catenin pathway plays vital roles in diverse biological processes, including cell differentiation, proliferation, migration, and insulin sensitivity. A recent study reported that the DNA-binding transcriptional factor SIX3 is essential during embryonic development vertebrates capable of downregulating target genes lung cancer, indicating negative regulation activation. However, SIX3-Wnt/β-catenin axis remains unknown. We measured expression TRIM27 as well investigated whether there...
Lung adenocarcinoma (LUAD), which accounts for 60% of non-small-cell lung cancers, is poorly diagnosed and has a low average 5-year survival rate (approximately 20%). It remains the leading cause cancer-related deaths worldwide. Studies on long noncoding RNAs (lncRNAs) in LUAD-related competing endogenous RNA (ceRNA) networks are limited. We aimed to identify novel prognostic biomarkers LUAD using bioinformatic tools data analysis. systemically integrated differentially expressed genes...
20(S)-Protopanaxadiol (PPD) is one of the bioactive ingredients in ginseng and possesses neuroprotective properties. Brain-type creatine kinase (CK-BB) an enzyme involved brain energy homeostasis via phosphocreatine–creatine system. We previously identified PPD as directly bound to CK-BB activated its activity vitro. In this study, we explored antidepressive effects that target CK-BB. First, conducted time course studies on CK-BB, behaviors, hippocampal structural plasticity responses...
The brown planthopper, Nilaparvata lugens (Stål) (Hemiptera: Delphacidae), is a classic example of resurgent pest induced by insecticides. It has been demonstrated that triazophos treatment causes an increase in the content male accessory gland proteins (Acps) can be transferred to females via mating, influencing female reproduction. However, mechanism this type insecticide-induced Acps males and subsequent stimulation reproduction are not well understood. To identify changes types...
Poplars are proposed for the phytoremediation of heavy metal (HM) polluted soil. Characterization genes involved in HM uptake and accumulation poplars is crucial improving efficiency. Here, Natural Resistance-Associated Macrophage Protein 1 (NRAMP1) encoding a transporter cadmium (Cd) transport was functionally characterized Populus × canescens. Eight putative PcNRAMPs were identified poplar genome most them primarily expressed roots. The expression PcNRAMP1 induced Cd-exposed roots it...
<title>Abstract</title> Background Protein arginine methyltransferase 1 (PRMT1) is the main enzyme that directly responsible for production of asymmetric dimethylarginine (ADMA), and upregulation PRMT1 observed in a variety malignancies, including esophageal cancer (ESCA). Dysregulation methylation caused by overexpression driver poor progression, detailed mechanism modulation currently unknown. Results The present study confirmed novel oncogenic ESCA. levels were significantly upregulated...