A5111215229- Extracellular vesicles in disease
- Optimism, Hope, and Well-being
- Thermal properties of materials
- Inflammasome and immune disorders
- Platelet Disorders and Treatments
- Blood groups and transfusion
- Cardiac Fibrosis and Remodeling
- Inhalation and Respiratory Drug Delivery
- Immune Cell Function and Interaction
- Nuclear Receptors and Signaling
- Cardiovascular Function and Risk Factors
- Immune Response and Inflammation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Research and Treatments
- Medicinal Plants and Bioactive Compounds
- Nanoparticles: synthesis and applications
- Regional Development and Environment
- Angiogenesis and VEGF in Cancer
- Phagocytosis and Immune Regulation
- Adenosine and Purinergic Signaling
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Biomarkers in Disease Mechanisms
- Coronary Interventions and Diagnostics
- Chronic Obstructive Pulmonary Disease (COPD) Research
Southwest Petroleum University
2024-2025
Zhejiang Chinese Medical University
2015-2025
Zhejiang A & F University
2025
Zhejiang University
2015
Anti-PD-1 therapy, effective in patients with various advanced tumors, still encounters the challenge of insensitivity most patients. Here, we demonstrate that PD-L1 on tumor cell-derived extracellular vesicles (TEVs) is critical for anti-PD-1 therapy resistance. Reducing endogenous and transferring exogenous TEVs abrogates induces resistance, respectively. Notably, sorted onto via endosomal sorting complex required transport after ubiquitination by UBE4A gradually upregulated progression....
Neointimal proliferation after vascular injury is a key mechanism of restenosis, major cause percutaneous transluminal angioplasty failure and artery bypass occlusion. Emodin, an anthraquinone with multiple physiological activities, has been reported to inhibit smooth muscle cells (VSMCs) that might intimal arterial thickening. Thus, in this study, we established rat model balloon-injured carotid investigated the therapeutic effect emodin its underlying mechanism. Intimal thickness was...
Doxorubicin (Dox) is an anti-tumor drug with a broad spectrum, whereas the cardiotoxicity limits its further application. In clinical settings, liposome delivery vehicles are used to reduce Dox cardiotoxicity. Here, we substitute extracellular vesicles (EVs) for liposomes and deeply investigate mechanism EV-encapsulated delivery. The results demonstrate that EVs dramatically increase import efficiency effects of in vitro vivo, benefits from unique entry pattern. Dox-loading repeat...
Abstract T‐cell haematological malignancies progress rapidly and have a high mortality rate effective treatments are still lacking. Here, we developed drug delivery system utilizing 293T cell‐derived extracellular vesicles (EVs) modified with an anti‐CD7 single‐chain variable fragment (αCD7/EVs). Given the challenges of chemotherapy resistance in patients malignancy, selected cytochrome C (CytC) Bcl2 siRNA ( siBcl2 ) as therapeutic agents loaded them into αCD7/EVs (αCD7/EVs/CytC/ ). We found...
Influenza A virus infections can cause acute lung injury (ALI) in humans; thus, the identification of potent antiviral agents is urgently required. Herein, effects salidroside on influenza virus-induced ALI were investigated a murine model. BALB/c mice intranasally inoculated with H1N1 and treated salidroside. The results this study show that treatment (30 60 mg/kg) significantly attenuated histological alterations inhibited inflammatory cytokine production. Salidroside also decreased...
Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disease, and a common clinically hemorrhagic disease caused by thrombocytopenia. A number of studies have found that the incidence ITP related to various virus infection, mechanism involving with organism immune factor direct effect. In this article, mechanisms infection are reviewed. Key words: Viral; Infection; Idiopathic
Objective To study the effects of nano silver (Ag) and titanium dioxide (TiO2) on content nucleic acid in staphylococcus aureus order to explore their antibacterial mechanisms. Methods After preparation beef extract peptone liquid cultures, minimal inhibitory concentrations (MICs) Ag TiO2 strains were determined. With 1/2 MICs TiO2, contents DNA RNA macromolecules from cultures measured determine damage degree cell membranes by ultraviolet spectrophotometer, then fluorescence...