A5087605849- Extracellular vesicles in disease
- Antimicrobial Resistance in Staphylococcus
- Immune cells in cancer
- Neonatal Respiratory Health Research
- MicroRNA in disease regulation
- Phagocytosis and Immune Regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- Respiratory Support and Mechanisms
- Autophagy in Disease and Therapy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Peptidase Inhibition and Analysis
- Bacterial Infections and Vaccines
- Erythrocyte Function and Pathophysiology
- Pneumonia and Respiratory Infections
- Heme Oxygenase-1 and Carbon Monoxide
- Thermal properties of materials
- Nosocomial Infections in ICU
- Bacterial biofilms and quorum sensing
- Cell Adhesion Molecules Research
- Epigenetics and DNA Methylation
- COVID-19 Clinical Research Studies
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- Bacterial Identification and Susceptibility Testing
Second Affiliated Hospital of Zhejiang University
2017-2024
The Second Nanning People's Hospital
2017
Zhejiang University
2017
Abstract Extracellular vesicles (EVs) are excellent potential vectors for the delivery of therapeutic drugs. However, issues with biological safety and disease targeting substantially limit their clinical application. EVs from red blood cells (RBC‐EVs) drug vehicles because unique safety. Here, we demonstrated that EVs, including RBC‐EVs, show natural liver accumulation. Mechanistically, environment induces macrophages to phagocytize RBC‐EVs in a C1q‐dependent manner. loaded antisense...
OBJECTIVE:To investigate the value of high-flow nasal cannula oxygen therapy after extubation in patients with acute respiratory failure.METHODS: A single-center, prospective, randomized, controlled pilot trial was conducted between January 2013 and December 2014.Sixty enrolled were randomized immediately into either a group (n=30) or an air entrainment mask at fixed inspired fraction (40%).The success rate therapy, hemodynamic parameters subjective discomfort (using visual analogue scale)...
The microRNAs miR-144 and -451 are encoded by a bicistronic gene that is strongly induced during red blood cell formation (erythropoiesis). Ablation of the miR-144/451 in mice causes mild anemia under baseline conditions. Here we show miR-144/451−/− erythroblasts exhibit increased apoptosis recovery from acute anemia. Mechanistically, depletion increases expression miR-451 target mRNA Cab39, which encodes co-factor for serine-threonine kinase LKB1. During erythropoietic stress, abnormally...
Epidemiological and clinical studies have shown that exposure to particulate matter (PM) is associated with an increased incidence of lung cancer metastasis. However, the underlying mechanism remains unclear. Here, we demonstrated central role PM-induced neutrophil recruitment in promoting We found reactive oxygen species (ROS)-mediated alveolar epithelial macroautophagy/autophagy was essential for initiating chemotaxis pre-metastatic niche formation lungs response PM exposure. During...
Glibenclamide displays an anti-inflammatory response in various pulmonary diseases, but its exact role lipopolysaccharide- (LPS-) induced acute lung injury (ALI) or respiratory distress syndrome (ARDS) remains unknown. Herein, we aimed to explore the effect of glibenclamide vivo and vitro on development LPS-induced ALI a mouse model. LPS stimulation resulted increases score, wet/dry ratio, capillary permeability lungs, as well total protein concentration, inflammatory cells, cytokines...
Background: CD93 reportedly facilitates tumor angiogenesis.However, whether regulates antitumor immunity remains undeciphered.Methods: Lung tissues, malignant pleural effusions (MPEs) were obtained from lung cancer patients.Blood was healthy volunteers and patients with anti-PD-1 therapy.Furthermore, p53 fl/fl LSL-Kras G12D , Ccr7 -/-, Cd93 -/-mice CD11c-DTR mice generated.Specifically, EM, NTA western blotting utilized to identify Tumor extracellular vesicles (TEVs).EV labeling, detection...
Doxorubicin (Dox) is an anti-tumor drug with a broad spectrum, whereas the cardiotoxicity limits its further application. In clinical settings, liposome delivery vehicles are used to reduce Dox cardiotoxicity. Here, we substitute extracellular vesicles (EVs) for liposomes and deeply investigate mechanism EV-encapsulated delivery. The results demonstrate that EVs dramatically increase import efficiency effects of in vitro vivo, benefits from unique entry pattern. Dox-loading repeat...
Although chimeric antigen receptor-modified (CAR) T cell therapy has been successfully applied in the treatment of acute B lymphocytic leukemia, its effect on Burkitt lymphoma (BL) and chronic leukemia (B-CLL) is unsatisfactory. Moreover, fatal side effects greatly impede CAR application. Extracellular vesicles (EVs) are excellent carriers therapeutic agents. Nevertheless, EVs mainly accumulate liver when administered without modification. As an envelope glycoprotein Epstein–Barr viruses,...
Abstract Neddylation, a posttranslational modification in which NEDD8 is covalently attached to target proteins, has emerged as an endogenous regulator of innate immunity. However, the role neddylation methicillin-resistant Staphylococcus aureus (MRSA) infection remains unknown. In this study, we found that was activated after MRSA vivo and vitro. Inhibition with MLN4924 promoted injury liver kidneys C57BL/6 mice bloodstream increased mortality. Blockade neddylation, either pharmacologically...
To investigate the clinical features and risk factors for methicillin-resistant Staphylococcus aureus (MRSA) pneumonia (MP) with secondary MRSA bloodstream infections (MRSA-BSI) (termed MP-BSI) compared MP alone to study incidence of MP-BSI among patients MP.This was a retrospective, single-center data derived from previous medical records. The cases were divided into groups: MP-BSI. determination independent relied on logistic regression analysis. Additionally, crude outcomes compared.A...
Abstract BackgroundMethicillin-resistant Staphylococcus aureus (MRSA) pneumonia (MP) and MRSA bloodstream infections (MRSA-BSI) are relatively often described, but MP with secondary MRSA-BSI (termed as MP-BSI) is few reported. Herein, we attempted to investigate the clinical features, risk factors outcomes of MP-BSI in comparison alone.MethodsClinical data from patients was retrospectively collected. The cases were divided into groups alone MP-BSI. Determination independent for relied on...