A5056874668- Sinusitis and nasal conditions
- Allergic Rhinitis and Sensitization
- Nasal Surgery and Airway Studies
- Head and Neck Surgical Oncology
- Asthma and respiratory diseases
- Olfactory and Sensory Function Studies
- COVID-19 epidemiological studies
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Meningioma and schwannoma management
- Immune Cell Function and Interaction
- Respiratory and Cough-Related Research
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Pituitary Gland Disorders and Treatments
- Obstructive Sleep Apnea Research
- Pneumonia and Respiratory Infections
- Craniofacial Disorders and Treatments
- Otolaryngology and Infectious Diseases
- COVID-19 Pandemic Impacts
- Tracheal and airway disorders
- Advanced Chemical Sensor Technologies
- COVID-19 diagnosis using AI
- T-cell and B-cell Immunology
- Spinal Fractures and Fixation Techniques
University of Cincinnati Medical Center
2019-2025
Harvard University
2012-2024
Sabin Vaccine Institute
2019-2024
Temple University
2023-2024
American Academy of Otolaryngology — Head and Neck Surgery
2023-2024
Royal Prince Alfred Hospital
2024
King Saud University
2024
UNSW Sydney
2024
University of Cincinnati
2020-2023
AID Atlanta
2023
Antiretroviral therapy can reduce human immunodeficiency virus type 1 (HIV-1) viremia to below the detection limit of ultrasensitive clinical assays (50 copies HIV-1 RNA/ml). However, latent persists in resting CD4+ T cells, and low residual levels free are found plasma. Limited characterization this has been done because number virions per sample. Using intensive sampling, we analyzed compared these viruses proviruses cells peripheral blood. For each patient, some plasma that were identical...
The minimal clinically important difference (MCID) of a patient-reported outcome measure (PROM) represents threshold value change in PROM score deemed to have an implication clinical management. MCID is frequently used interpret the significance results from studies that use PROMs. However, understanding many caveats MCID, as well its strengths and limitations, necessary. objective this article provide review calculation, interpretation, MCID.MEDLINE PubMed Central.Literature...
Objective Olfactory dysfunction (OD)—hyposmia or anosmia—is a symptom of coronavirus disease 2019 (COVID‐19), caused by the novel coronavirus, severe acute respiratory syndrome 2 (SARS‐CoV‐2). We sought to better determine prevalence, severity, and timing OD in COVID‐19 relative other sinonasal pulmonary symptoms. Study Design Prospective, cross‐sectional. Setting Regional/cantonal hospital. Subjects In total, 103 patients diagnosed with reverse transcription polymerase chain reaction...
Severe chronic rhinosinusitis with nasal polyps (CRSwNP), a form of diffuse bilateral (usually type 2) CRS, is debilitating disease significant impact on quality life (QoL). With novel knowledge and treatment options becoming available, there growing need to update or revise key definitions enable communication across different specialties dealing agree goals care in CRSwNP. The European Forum for Research Education Allergy Airway diseases (EUFOREA) EPOS expert members discussed how measure...
Resting CD4+ T-cell populations from human immunodeficiency virus type 1 (HIV-1)-infected individuals include cells with integrated HIV-1 DNA. In showing suppression of viremia during highly active antiretroviral therapy (HAART), resting do not produce without cellular activation. To determine whether the nonproductive nature infection in T is due to retroviral integration into chromosomal regions that are repressive for transcription, we used inverse PCR characterize sites vivo patients on...
We develop a mathematical model that explicitly represents many of the known signaling components mediating translocation insulin-responsive glucose transporter GLUT4 to gain insight into complexities metabolic insulin pathways. A novel mechanistic postreceptor events including phosphorylation receptor substrate-1, activation phosphatidylinositol 3-kinase, and subsequent downstream kinases Akt protein kinase C-ζ is coupled with previously validated subsystem models binding, recycling,...
ABSTRACT The mechanism of CD4 + T-cell depletion during chronic human immunodeficiency virus type 1 (HIV-1) infection remains unknown. Many studies suggest a significant role for activation. We assumed that the pathogenic process excessive activation would be reflected in transcriptional profiles activated T cells. Here we demonstrate programs vivo-activated cells from untreated HIV-positive (HIV ) individuals are clearly different those HIV-negative − individuals. observed dramatic...
The human papillomavirus (HPV) has been identified as a causative factor in 20% to 25% of all head and neck squamous cell carcinomas (HNSCC). Ongoing research suggests that the presence HPV DNA HNSCC predicts positive prognosis with respect disease-free overall survival. However, most studies have limited by heterogeneity treatment regimens and/or anatomic subsites tumor origin. In this study, we correlate clinical outcomes status for patients oropharyngeal who were uniformly treated...
Aerosol‐generating procedures in the office represent a major concern for health care–associated infection of patients and care providers by SARS‐CoV‐2, causative agent coronavirus disease 2019 (COVID‐19). Although Centers Disease Control Prevention has not yet provided any recommendations use portable air purifiers, purifiers with high‐efficiency particulate (HEPA) filters have been discussed as an adjunctive means decontamination SARS‐CoV‐2 aerosols settings. This commentary discusses HEPA...
Objective To evaluate the prevalence and severity of obstructive sleep apnea in infants with Pierre Robin sequence prior to airway intervention determine whether snoring correlates presence this population. Design Retrospective case series. Setting Urban tertiary care teaching hospital. Participants/Methods Review who underwent polysomnography first year life from 2002 2007. Only results initial were analyzed. A subgroup consecutive prospectively tested patients was also evaluated. Results...
Periapical radiolucencies, which can be detected on panoramic radiographs, are one of the most common radiographic findings in dentistry and have a differential diagnosis including infections, granuloma, cysts tumors. In this study, we seek to investigate ability with 24 oral maxillofacial (OMF) surgeons assess presence periapical lucencies compare these performance predictive deep learning algorithm that developed using curated data set 2902 de-identified radiographs. The mean diagnostic...
Background Previous studies have identified subdomains of the 22‐item Sino‐Nasal Outcome Test (SNOT‐22), reflecting distinct and largely independent categories chronic rhinosinusitis (CRS) symptoms. However, no study has validated subdomain structure SNOT‐22. This aims to validate existence underlying symptom SNOT‐22 using confirmatory factor analysis (CFA) develop a model that practitioners researchers can use describe CRS symptomatology. Methods A total 800 patients with were included into...
Objective The objective of this study was to determine the burden depressed mood and anxiety in COVID‐19, associated disease characteristics. Materials Methods This is a prospective, cross‐sectional 114 COVID‐19 positive patients diagnosed using RT‐PCR‐based testing over 6‐week period. two‐item Patient Health Questionnaire (PHQ‐2) Generalized Anxiety Disorder questionnaire (GAD‐2) were used measure level, respectively, at enrollment for participants' baseline, pre‐COVID‐19 state. Severity...
Background: The degree to which different sinonasal symptoms contribute the overall quality of life (QOL) detriment in chronic rhinosinusitis (CRS) patients remains unknown. In this study we sought characterize effect CRS on general health-related QOL patients. Methodology: We performed a prospective cross-sectional 131 adult with CRS. Sinonasal were evaluated using 22-item Outcomes Test (SNOT-22) and was EuroQol 5-Dimensional survey (EQ5D) visual analog scale (EQ5D-VAS). Health utility...
Background Chronic rhinosinusitis (CRS) is associated with varied head and neck symptomatology quality-of-life impairments that are not necessarily correlated each other or objective measures of disease. Objective To determine how clustering patterns CRS symptoms associate clinical findings. Methods Symptom scores from 193 Sinonasal Outcomes Test-22 (SNOT-22) questionnaires, 177 consecutive patients, were analyzed by principal component analysis (PCA) to uncover fewer physiologically...
Objective Opioid use disorder (OUD), which includes the morbidity of dependence and mortality overdose, has reached epidemic proportions in United States. Overprescription opioids can lead to chronic misuse, unused narcotics after surgery their diversion. Research supports that most patients do not take all prescribed surgeons are second largest prescribers The introduction those with OUD often begins prescription opioids. Reducing number extra available through smaller prescriptions, safe...
<h3>Importance</h3> School and classroom allergens particles are associated with asthma morbidity, but the benefit of environmental remediation is not known. <h3>Objective</h3> To determine whether use a school-wide integrated pest management (IPM) program or high-efficiency particulate air (HEPA) filter purifiers in classrooms improve symptoms students active asthma. <h3>Design, Setting, Participants</h3> Factorial randomized clinical trial IPM HEPA was conducted from 2015 to 2020 (School...