A5085447714- Renal Transplantation Outcomes and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Traditional Chinese Medicine Analysis
- Analytical Chemistry and Chromatography
- Transplantation: Methods and Outcomes
- Atrial Fibrillation Management and Outcomes
- Pneumocystis jirovecii pneumonia detection and treatment
- Lung Cancer Treatments and Mutations
- Food Quality and Safety Studies
- Organ Transplantation Techniques and Outcomes
- Viral Infections and Immunology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Traditional Chinese Medicine Studies
- Ferroptosis and cancer prognosis
- Antiplatelet Therapy and Cardiovascular Diseases
- Phytochemicals and Antioxidant Activities
- Chronic Myeloid Leukemia Treatments
- Antimicrobial Resistance in Staphylococcus
- Synthesis and Biological Evaluation
- Blood Coagulation and Thrombosis Mechanisms
- Bacterial Identification and Susceptibility Testing
- Postharvest Quality and Shelf Life Management
- Natural product bioactivities and synthesis
- Cytokine Signaling Pathways and Interactions
Affiliated Hospital of Hebei University
2025
First Affiliated Hospital of GuangXi Medical University
2024
Guangxi Medical University
2024
China-Japan Friendship Hospital
2020-2024
Zhejiang Cancer Hospital
2022-2023
Chinese Academy of Sciences
2023
Beijing Polytechnic
2014
Guangxi Research Institute of Chemical Industry
2010
Deutsch Amerikanisches Institut Saarland
2009
Gastric cancer (GC) is one of the most common malignant tumors in world.GPx4, as core regulator ferroptosis, has become a potential molecular target for developing anticancer agents.In present study, we found that GPx4 was overexpressed and negatively correlated with poor prognosis GC, while it associated GC development.Molecular docking structure-based virtual screening assays were used to screen inhibitors, identified novel inhibitor, polyphyllin B (PB), which can induce ferroptosis by...
Objective: To explore the analysis of application effect tirilizumab combined with conventional chemotherapeutic drugs (paclitaxel + carboplatin) in clinical treatment advanced non-small cell lung cancer patients. Methods: Seventy-five patients who received chemotherapy a hospital from July 2023 to June 2024 were selected as objects, and grouped according choice drugs, 37 regular included control group, other 38 paclitaxel carboplatin observation efficacy two groups was compared. Results:...
To investigate the prevalence and severity of depression in patients with ischaemic stroke identify its associated factors using a cross-sectional design over 6-month period. This study included 499 who met diagnostic inclusion criteria. Depression levels were assessed Hamilton Rating Scale (HAMD). Data collection demographic variables, clinical data self-reported measures. Neurological deficits National Institutes Health Stroke (NIHSS), whereas activities daily living (ADL) evaluated ADL...
Introduction Kiwifruit is susceptible to ripening and senescence during postharvest storage, leading fruit softening, rotting, nutrient loss, affecting commercial economic values. Hormones delay by regulating physiology metabolism, but their specific effects mechanisms must be further investigated. Methods To extend the storage duration of kiwifruit, we conducted a study using 'Yan Nong 3' kiwifruit as our test material. The fruits were treated with varying concentrations Brassinolide (BRs),...
Tacrolimus and voriconazole are usually used simultaneously in lung transplantations. Voriconazole can increase tacrolimus concentrations by inhibiting the cytochrome P450 (CYP) enzyme, which poses a great challenge for dose adjustment. The aim of this study is to clarify correlation between exposure trough (C0 ), establish population pharmacokinetic model including (VOZ) as covariate optimization. All data were retrospectively collected from transplantation patients who subjected...
Rivaroxaban is a popular direct factor Xa inhibitor used for anticoagulation therapy in patients with nonvalvular atrial fibrillation (NVAF). The aim of this study was to establish population pharmacokinetic (PPK) model rivaroxaban elderly Chinese fibrillation, evaluate precision dosing regimens, and analyze hemorrhagic risk after treatment. A 1-compartment PK estimated glomerular filtration rate (eGFR), total bilirubin (TBIL), ABCB1 rs1045642 as major covariates apparent clearance developed...
What is known and objective Teicoplanin widely used for the treatment of infections caused by drug-resistant Gram-positive bacteria. Since there a good correlation between trough levels clinical outcome, therapeutic drug monitoring (TDM) recommended to achieve better curative effects. However, TDM teicoplanin not routine in China. So, programme was initiated 2017, including both HPLC method establishment interlaboratory quality assessment, measurement teicoplanin. Methods A main centre...
Hemorrhage events occur most frequently in anticoagulant therapy for non-valvular atrial fibrillation (NVAF). Rivaroxaban is used widely routine anticoagulation care. Genetic polymorphisms are thought to contribute the wide intraindividual variability seen rivaroxaban metabolism and response. The aim of this study was evaluate effect drug transport related single-nucleotide (SNPs) on risk a hemorrhage event. A total 216 Chinese patients with NVAF were enrolled study. therapy. plasma...
Abstract Atorvastatin is a widely prescribed cholesterol‐lowering drug that inhibits 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase to reduce lipid levels. This study aimed establish population pharmacokinetic and pharmacodynamic model for atorvastatin in Chinese lung transplant recipients (LTRs), particularly those using voriconazole (VOR) with different genotypes. It evaluated precise dosing regimens analyzed the correlation between exposure clinical outcomes. nonlinear mixed‐effects was...
The prognostic impact of preoperative gamma-glutamyl transpeptidase to platelet ratio (GPR) levels in patients with solitary hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) following radical resection has not been established.
Therapeutic drug monitoring is an essential tool when managing the therapeutic use of immunosuppressant cyclosporine A (CsA) in cases with solid organ transplantation. In China, concentration CsA primarily measured using immunoassays. However, existing literature recommends mass spectrometry as current gold standard for quantitation CsA. present study, it was attempted to develop a novel application determine concentrations by ultra‑performance liquid chromatography coupled high‑resolution...
Partial or complete deficiency in the dihydropyrimidine dehydrogenase (DPD) has been observed 3%–5% and 0.1% of general population, respectively. It causes severe toxicity context 5-fluorouracil (5-FU) therapy. However, current tests for determination DPD have limitations routine clinical usage.Therefore, an vitro approach simulating 5-FU degradation was established by mixing with blank whole blood matrix this study. The effects initial concentrations temperatures on activities were...
Abstract Background Erratic tacrolimus (Tac) exposure is associated with poor long-term outcomes after kidney transplantation. However, detailed data on the association in lung transplant recipients are lacking. Aim We hypothesized that Tac intra-patient variability (Tac IPV) or mean concentration was chronic allograft dysfunction (CLAD) and survival Methods Data from 132 were analyzed retrospectively. trough during 0–6, 6–12 12–24 months transplantation collected. IPV calculated based...