A5101527019- Antibiotics Pharmacokinetics and Efficacy
- Renal Transplantation Outcomes and Treatments
- Antimicrobial Resistance in Staphylococcus
- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Antifungal resistance and susceptibility
- Pharmacological Effects and Toxicity Studies
- Antibiotic Resistance in Bacteria
- Pneumocystis jirovecii pneumonia detection and treatment
- Biochemical effects in animals
- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Cytomegalovirus and herpesvirus research
- Health Systems, Economic Evaluations, Quality of Life
- Pregnancy and Medication Impact
- Acute Lymphoblastic Leukemia research
- Epilepsy research and treatment
- Metabolism and Genetic Disorders
- Bacterial Identification and Susceptibility Testing
- Alkaloids: synthesis and pharmacology
- Transplantation: Methods and Outcomes
- HIV/AIDS drug development and treatment
- Exercise and Physiological Responses
- Heat shock proteins research
- Chronic Myeloid Leukemia Treatments
Jinzhou Medical University
2020-2025
China-Japan Friendship Hospital
2014-2024
Second Hospital of Shandong University
2024
Central University of Finance and Economics
2020
Hainan Normal University
2018
Southern Medical University
2016-2017
Nanfang Hospital
2016-2017
National Clinical Research
2017
Guangxi Center for Disease Prevention and Control
2014
Center for Disease Control
2014
Clinical practice guidelines or recommendations often require timely and regular updating as new evidence emerges, because this can alter the risk-benefit trade-off. The scientific process of developing accompanied by adequate implementation improve outcomes. To promote better management patients receiving vancomycin therapy, we updated guideline for therapeutic drug monitoring (TDM) published in 2015.Our complied with standards trustworthy guidelines, including timeliness rigor process,...
Guideline development should be based on the quality of evidence, balance benefits and harms, economic evaluation patients' views preferences. Therefore, these factors were considered in a new guideline for therapeutic drug monitoring (TDM) vancomycin. To develop an evidence-based vancomycin TDM to promote standardized clinical practice China. We referred WHO Handbook Development used Grading Recommendations Assessment, Evaluation (GRADE) system rate evidence grade strength recommendations,...
Abstract Objective Oxidative stress plays a pivotal role in neurodegenerative diseases. Astaxanthin (AST) can play neuroprotective owing to its long-chain conjugated unsaturated double bond, which imparts potent antioxidant, anti-neuroinflammatory, and anti-apoptotic properties. However, the biological mechanisms underlying these effects remain unknown. Therefore, this study aimed investigate validate protective effect of AST on neuronal senescence apoptosis caused by oxidative induced...
Background: Parkinson's disease (PD) is a neurodegenerative in which the neostriatum, including caudate nucleus (CN) and putamen (PU), has an important role pathophysiology. However, conventional magnetic resonance imaging (MRI) lacks sufficient specificity to diagnose PD. Therefore, study's aim was investigate feasibility of using radiomics approach distinguish PD patients from healthy controls on T2-weighted images neostriatum provide basis for clinical diagnosis Methods: 69 age-...
Aims A lot of medication risks related to high‐dose methotrexate (HDMTX) therapy still remain be identified and standardized. This study aims establish an evidence‐based practice guideline for individualized HDMTX. Methods The was launched by the Division Therapeutic Drug Monitoring, Chinese Pharmacological Society. developed following WHO handbook development methodology medicine (EBM). initially registered in International Practice Guidelines Registry Platform (IPGRP‐2017CN021). Systematic...
Several large prospective studies show an association between serum uric acid (SUA) and cancer, however there is a lack of evidence in China. We aimed to investigate the effects SUA levels on cancer incidence mortality This study included 20,577 adult hypertensive patients with valid measurements who participated China Stroke Primary Prevention Trial where subjects were randomly assigned receive double‐blind treatment either 10 mg enalapril (n = 10,286) or 10.8 enalapril‐folic 10,291)....
Objectives: Teicoplanin has been extensively used in the treatment for infections caused by gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA). However, current teicoplanin is challenging due to relatively low and variable concentrations under standard dosage regimens. This study aimed investigate population pharmacokinetics (PPK) characteristics of adult sepsis patients provide recommendations optimal dosing Methods: A total 249 serum concentration samples...
Drug addiction is a major public health issue, yet the underlying adaptation of neural networks by drugs abuse not fully understood. We have previously linked chaperone heat shock protein 70 (Hsp70) to drug-induced adaptations. Focusing on NAc core and shell, present study aims provide further findings for our understanding relation between behavioural sensitization morphine Hsp70 at transcriptional functional levels in rats. Firstly, we delineated characteristics induced single exposure...
Little is known about the influence of extracorporeal membrane oxygenation (ECMO) on pharmacokinetics (PK) caspofungin. The aim this study was to describe population PK caspofungin in patients with and without ECMO during postoperative period lung transplantation (LTx) investigate covariates influencing PK. We compared non-ECMO patients, before after weaning as self-controls, analyzed changes Eight serial blood samples were collected from each patient for analysis. described using nonlinear...
Objectives Acute kidney injury (AKI) is a common complication after lung transplantation (LTx) which closely related to the poor prognosis of patients. We aimed explore potential risk factors and outcomes associated with early post-operative AKI LTx.Methods A retrospective study was conducted in 136 patients who underwent LTx at our institution from 2017 2019. defined according Kidney Disease: Improving Global Outcomes (KDIGO) guideline. Univariate multivariate analyses were identify AKI....
The presence of extracorporeal membrane oxygenation (ECMO) is suggested to further exacerbate the pharmacokinetics (PK) alterations that occur during critical illness. objectives this study were determine population PK model polymyxin B in critically ill patients with or without ECMO support investigated influence on variability and identify an optimal dosing strategy.Forty-four enrolled, including eight support. Eight serial serum samples collected from each patient at steady state. was...
Carbapenem pharmacokinetic (PK) profiles are significantly different in critically ill patients because of the drastic variability patients' physiological parameters. Published population PK studies have mainly focused on specific diseases, and majority these had small sample sizes. The aim this study was to develop a model imipenem that estimated influence various clinical biological covariates use extracorporeal membrane oxygenation (ECMO) continuous renal replacement therapy (CRRT). A...
To investigate plasma-free carnitine (Fc), acylcarnitine (Ac), and total (Tc) levels in patients undergoing hemodialysis (HD), to explore their clinical significance.A of 20 subjects were the normal control group 133 HD divided into medicated (received treatment) non-medicated groups. The was further three subgroups according Fc level: = 80-199, 200-299, ≥ 300 μmol/L. We used non-derivative tandem mass spectrometry determine levels, symptoms such as weakness, hypotension, muscle cramps...
Tacrolimus and voriconazole are usually used simultaneously in lung transplantations. Voriconazole can increase tacrolimus concentrations by inhibiting the cytochrome P450 (CYP) enzyme, which poses a great challenge for dose adjustment. The aim of this study is to clarify correlation between exposure trough (C0 ), establish population pharmacokinetic model including (VOZ) as covariate optimization. All data were retrospectively collected from transplantation patients who subjected...