A5100660172- Endometrial and Cervical Cancer Treatments
- Heart Rate Variability and Autonomic Control
- Cervical Cancer and HPV Research
- Gout, Hyperuricemia, Uric Acid
- Bone health and osteoporosis research
- Growth Hormone and Insulin-like Growth Factors
- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Salivary Gland Tumors Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Risk Factors
- Cardiovascular Function and Risk Factors
- Alcohol Consumption and Health Effects
- Gestational Diabetes Research and Management
- Optical Imaging and Spectroscopy Techniques
- Colorectal and Anal Carcinomas
- Hormonal Regulation and Hypertension
- Spaceflight effects on biology
- Cardiovascular Syncope and Autonomic Disorders
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Prenatal Screening and Diagnostics
- Electromagnetic Fields and Biological Effects
Beijing Tian Tan Hospital
2025
Capital Medical University
2025
Nanjing University of Chinese Medicine
2024
Nankai University
2024
Chinese PLA General Hospital
2023
Southwestern University
2022
National Clinical Research
2021
Wuhan University
2021
Renmin Hospital of Wuhan University
2021
China XD Group (China)
2012-2020
Objective: Butyrate, a short-chain fatty acid (SCFA) produced by the intestinal microbiota, plays protective role in cardiovascular diseases (CVDs), but mechanisms involved this process remain unelucidated. We aimed to explore effect of butyrate on myocardial ischemia/reperfusion (I/R) injury through gut-brain neural circuit. Methods: Rats were randomly divided into four groups: sham group (sham), I/R (I/R), I/R+ (butyrate), and butyrate+ vagotomy (vagotomy). The rats treated with sodium for...
To assess baroreflex function under closed-loop conditions, a new approach was used to generate large and physiological perturbations in arterial pressure. Blood pressure (BP) R-R interval were recorded continuously 20 healthy young (33 ± 8 yr) eight elderly subjects (66 6 yr). Repeated squat-stand maneuvers at the frequencies of 0.05 0.1 Hz performed produce periodic oscillations BP provoke baroreflex. effects muscle reflex and/or central command on baroreflex, passive conducted using...
Meningioma is a common tumor of the central nervous system but effective therapies for malignant meningiomas are still lacking. Therefore, development novel therapeutic reagents urgently needed. SYHA1813 compound and our previous study demonstrated its potent anti-tumor activity on glioblastoma through inhibition macrophages human umbilical vein endothelial cells (HUVECs). However, precise functional role in remains unclear. We aimed to investigate direct tumor-inhibitory effects meningioma...
Glioma is the most common malignant tumor in central nervous system with significant challenges for its treatment and prognosis. Based on publicly available genome-wide association study data, this employed a bidirectional, two-sample Mendelian randomization (MR) analysis, combined Bayesian weighted MR, to investigate causal effect of 233 circulating metabolic traits glioma subtypes, expectation discovering new diagnostic therapeutic targets. The MR revealed that Total cholesterol total...
Background: Diabetic cardiomyopathy (DCM) is considered to be a distinct clinical entity independent of concomitant macro- and microvascular disorders, which initiated partly by disturbances in energy substrates. This study was observe the dynamic modulations berberine DCM rats explore changes lipidomic profiles myocardial tissue. Methods: Sprague-Dawley (SD) were fed high-sucrose high-fat diet (HSHFD) for totally 22 weeks intraperitoneally (i.p.) injected with 30 mg/kg streptozotocin (STZ)...
Du-Zhong has a long history of being used in traditional Chinese formulas to treat bone related diseases. The objective the present study is systematically investigate effects cortex extract (DZCE) on disuse-induced osteoporosis. Rats were randomly divided into four groups, and three groups treated with hind limb suspension (HLS). Control HLS group received deionized distilled water, while other two alendronate (2.0 mg/kg/day) DZCE (300 respectively by intragastric gavage for six weeks (two...
We sought to examine the regulation of cerebral blood flow during 10 min recovery from mild, moderate, and heavy cycling exercise by measuring middle artery velocity (MCA V). Transfer function analyses between changes in arterial pressure MCA V were used assess frequency components dynamic autoregulation (CA). After mild moderate exercise, decreases mean (MAP) Vm) small. However, following MAP was rapidly markedly reduced, whereas Vm decreased slowly (-23 +/- 4 mmHg -4 1 cm/s after for Vm,...
The aim of this study was to investigate the prognostic factors and evaluate impact adjuvant therapy on clinical outcome for early-stage cervical cancer.The clinical-pathological data all 1,335 patients with International Federation Gynecology Obstetrics (FIGO) Ib-IIa cancer treated primary radical surgery at Chinese National Cancer Center between May 2007 Dec 2013 were retrospectively reviewed. median follow-up 70 months.Of patients, 61.6% cases received therapy, 5-year disease-free...
Whole body heating increases muscle sympathetic nerve activity (MSNA); however, the effect of heat stress on spectral characteristics MSNA is unknown. Such information may provide insight into mechanisms stress-induced activation. The purpose present study was to test hypothesis that changes in systolic blood pressure variability parallel variability. In 13 healthy subjects, MSNA, electrocardiogram, arterial (via Finapres), and respiratory were recorded under both normothermic conditions....
Several large prospective studies show an association between serum uric acid (SUA) and cancer, however there is a lack of evidence in China. We aimed to investigate the effects SUA levels on cancer incidence mortality This study included 20,577 adult hypertensive patients with valid measurements who participated China Stroke Primary Prevention Trial where subjects were randomly assigned receive double‐blind treatment either 10 mg enalapril (n = 10,286) or 10.8 enalapril‐folic 10,291)....
Background . Pregnancy-induced hypertension (PIH) remains a major cause of morbidity and mortality in pregnancy worldwide. This study was designed to the blood pressure-lowering effect resveratrol (RES) salt-induced hypertensive pregnant rat model. Methods Forty female Sprague Dawley (SD) rats were randomized into 4 groups: Normal Preg (0.9% salt diet), + RES diet plus daily oral for weeks), Salt (8% weeks). Noninvasive pressure recorded on gestational days 7 14. On day 19, foetuses weighed,...
<i>Background:</i> It has been demonstrated that a decrease in vagal cardiac function compromises arterial blood pressure (ABP) stability during orthostatic challenge. Augmentations low-frequency (LF) ABP oscillations are indicative of this change autonomic hemodynamic control. Aging is associated with diminished baroreflex sensitivity and dysfunction. However, the effect aging on an challenge remains to be elucidated. <i>Objective:</i> The purpose study was...
The alveolar bone marrow mesenchymal stem cells (ABM-MSCs) play an important role in oral healing and regeneration. Insulin is considered to improve impaired bones due local factors, systemic factors pathological conditions. However, the effect of insulin on formation ability ABM-MSCs still needs be elucidated. aim this study was determine responsiveness rat explore underlying mechanism. We found that promoted proliferation a concentration-dependent manner, which 10-6 M exerted most...
The receptor tyrosine kinase Axl is involved in diabetic vascular disease. This study aims to investigate the effect of high glucose on endothelial cells injury and expression hypoxia condition vitro, we present details mechanism associated with overexpression rescue injury. Our results showed that impaired both human umbilical vein (HUVECs) EAhy926 angiogenesis condition. In addition, inhibits hypoxia-inducible factor 1-α (HIF-1α) protein significantly reversed dysfunction glucose/hypoxia....
To find a more potent alternative with less oestrogen-related side effects for hormone replacement therapy (HRT) in postmenopausal osteoporosis, we designed and synthesized NO-releasing prodrug of genistein (NO-G) according to the structure NONSAIDs. The purpose this study was evaluate on bone ovariectomised (OVX) rats. Forty-eight adult Sprague-Dawley female rats were treated vehicle, 9 mg/kg 4.5, or 18 NO-G by oral administration daily. bioassays performed terms mineral density (BMD),...
Animal studies suggest that nitric oxide (NO) plays an important role in buffering short-term arterial pressure variability, but data from humans addressing this hypothesis are scarce. We evaluated the effects of NO synthase (NOS) inhibition on blood (BP) variability eight healthy subjects supine position and during 60 degrees head-up tilt (HUT). Systemic NOS was blocked by intravenous infusion N(G)-monomethyl-L-arginine (L-NMMA). Electrocardiogram beat-by-beat BP finger (Finapres) were...