A5086754389- Vagus Nerve Stimulation Research
- Cardiac Ischemia and Reperfusion
- Reproductive Biology and Fertility
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Blood Pressure and Hypertension Studies
- Atrial Fibrillation Management and Outcomes
- Ovarian function and disorders
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Tissue Engineering and Regenerative Medicine
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Risk Factors
- Sperm and Testicular Function
- Plant chemical constituents analysis
- Metabolomics and Mass Spectrometry Studies
- Synthesis of Organic Compounds
- Pharmacological Receptor Mechanisms and Effects
- Supply Chain Resilience and Risk Management
- Domain Adaptation and Few-Shot Learning
- Medical Imaging Techniques and Applications
- Cardiac Arrhythmias and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Nicotinic Acetylcholine Receptors Study
- Cardiac Health and Mental Health
The First Affiliated Hospital, Sun Yat-sen University
2025
Sun Yat-sen University
2025
Wuhan University
2021-2024
Renmin Hospital of Wuhan University
2021-2024
Sichuan University
2023
University of North Carolina at Chapel Hill
2020-2021
North Carolina State University
2020-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2021
Peking Union Medical College Hospital
2020-2021
Beijing Hospital
2020
The engineering of aggregation-induced emission luminogens (AIEgen) based covalent organic frameworks (COFs), TDTA-COF, BTDTA-COF, and BTDBETA-COF are reported, as hyperthermia agents for inhibiting the occurrence malignant ventricular arrhythmias (VAs). These AIE COFs exhibit dual functionality, they not only directly modulate function neural activity stellate ganglion (SG) through local therapy (LHT) but also induce browning white fat improve neuroinflammation peri-SG microenvironment,...
Obesity and imbalance in lipid homeostasis contribute greatly to heart failure with preserved ejection fraction (HFpEF), the dominant form of failure. Few effective therapies exist control metabolic alterations homeostasis.
Vagal responses and phrenic activation are commonly observed during pulsed field ablation (PFA). However, whether the vagal activations nerve damage or a neurological stress response due to electrical stimulation is unclear.The purpose of this study was evaluate effect PFA system for performing pulmonary vein isolation on autonomic nervous system.Patients with paroxysmal atrial fibrillation (AF) who underwent between August 2021 November were included. Nerve injury biomarkers heart rate...
Objective: Butyrate, a short-chain fatty acid (SCFA) produced by the intestinal microbiota, plays protective role in cardiovascular diseases (CVDs), but mechanisms involved this process remain unelucidated. We aimed to explore effect of butyrate on myocardial ischemia/reperfusion (I/R) injury through gut-brain neural circuit. Methods: Rats were randomly divided into four groups: sham group (sham), I/R (I/R), I/R+ (butyrate), and butyrate+ vagotomy (vagotomy). The rats treated with sodium for...
Background The advantages of multimodal digitally transformed mobile health management for patients diagnosed with mild to moderate hypertension are not yet established. Objective We aim evaluate the therapeutic benefits a novel WeChat-based digital transforming model in blood pressure (BP) management. Methods This randomized controlled clinical trial included 175 individuals new-onset who were admitted our center between September and October 2022. randomly assigned either intervention...
Doxorubicin (Dox) poses a considerable threat to patients owing its cardiotoxicity, thus limiting clinical utility. Optimal cardioprotective intervention strategies are needed suppress tumor growth but also minimize cardiac side effects. Here, we showed that tragus vagus nerve stimulation (tVNS) improved the imbalanced autonomic tone, ameliorated impaired function and fibrosis, attenuated myocyte apoptosis, mitochondrial dysfunction compared those in Dox group. The beneficial effects were by...
Summary Uterine natural killer ( uNK ) cells are the most abundant lymphocyte population in feto–maternal interface during early gestation, and play a significant role establishment maintenance of pregnancy‐related vascularization, as well tolerance to fetus. Tumour necrosis factor‐like weak inducer apoptosis TWEAK its receptor, fibroblast growth factor‐inducible molecule (Fn14), involved preventing local cytotoxicity counterbalancing cytotoxic function cells. Here, we studied regulation...
Celastrol has widespread therapeutic applications in various pathological conditions, including chronic inflammation. Previous studies have demonstrated the potent cardioprotective effects of celastrol. Nevertheless, limited attention been given to its potential reducing ventricular arrhythmias (VAs) following myocardial infarction (MI). Hence, this study aimed elucidate mechanisms underlying regulatory celastrol on VAs and cardiac electrophysiological parameters rats after MI.
Primary ovarian insufficiency (POI) normally occurs before age 40 and is associated with infertility. Hormone replacement therapy often prescribed to treat vasomotor symptom, but it cannot restore function or fertility. Stem cell has been studied for the treatment of POI. However, application live stem cells suffered from drawbacks, such as low retention/engraftment rate, risks tumorigenicity immunogenicity, lack off-the-shelf feasibility.
Current contraceptive methods come with a number of drawbacks, including low efficacy, in the case commercial gels, and reduction quality sexual intercourse, condoms. Adding pharmacologically-active agents to gels holds potential improve experience, hardbor safety hygiene. In this study, we fabricated carbomer-based gel consisting three agents: tenofovir, gossypol acetate, nitroglycerin (TGN), pH adjusted 4.5 (to be compatible vagina). vitro, component proved an effective spermicide. When...
Left stellate ganglion (LSG) hyperactivity is a critical factor in ventricular arrhythmias (VAs), and inhibiting LSG activity remains challenging. Carbon nanotubes (CNTs) are gaining popularity as promising nanomedicines for applications neuromodulation owing to their exceptional physicochemical properties capacity interface with neurons neuronal circuits. We have fabricated multiwalled CNTs coated 1,2-diphytanoyl-sn-glycero-3-phosphocholine (PC–CNTs) explored neuromodulatory effects...
Background: Cryoablation (CRYO) is a novel catheter ablation technique for atrial fibrillation (AF). However, uncertainty persists regarding the role of metabolic modifications associated with CRYO. This study was aimed at exploring whether CRYO influences signature – possibility not previously investigated. Methods: Paired serum samples from patients AF (n = 10) were collected before and 24 h after Untargeted metabolomic analysis conducted LC-MS. Univariate multivariate analyses applied to...
<title>Abstract</title> <bold>Objective:</bold> The purpose of the current research was to assess inhibitory effect and potential mechanism Ruji decoction (RJF) combined with 5-fluorouracil (5-FU) on TNBC growth through network pharmacology <italic>in vivo</italic> experiments. <bold>Methods:</bold> Compounds in RJF aqueous extracts were identified their contents determined by high performance liquid chromatography. Network used screen targets for breast cancer. Subsequently, action...
Background: Cryoablation (CRYO) is a novel catheter ablation technique for atrial fibrillation (AF). However, uncertainty persists regarding the role of metabolic modifications associated with CRYO ablation. This study aimed to explore whether influences signature, which has never been investigated before.
<sec> <title>BACKGROUND</title> The advantages of multimodal digitally transformed mobile health management for patients diagnosed with mild to moderate hypertension are not yet established. </sec> <title>OBJECTIVE</title> We aim evaluate the therapeutic benefits a novel WeChat-based digital transforming model in blood pressure (BP) management. <title>METHODS</title> This randomized controlled clinical trial included 175 individuals new-onset who were admitted our center between September...
Background: The clinical outcomes following a myocardial ischemia-reperfusion (I/R) injury are strongly associated with the intensity and duration of inflammation splenic nerve (SpN) is indispensable for anti-inflammatory reflex. Objectives We aimed to investigate whether stimulation (SpNS) plays cardioprotective role in ischemic potential underlying mechanism.Methods: SpNS having no influence on heart rate was tested used as subthreshold stimulus. Subthreshold performed continuous-mode 1...
Background: The clinical outcomes following a myocardial ischemia-reperfusion (I/R) injury are strongly associated with the intensity and duration of inflammation splenic nerve (SpN) is indispensable for anti-inflammatory reflex. Objectives: We aimed to investigate whether stimulation (SpNS) plays cardioprotective role in I/R potential underlying mechanism.Methods: SpNS having no influence on heart rate was tested used as subthreshold stimulus. Sprague-Dawley rats were randomly divided into...