A5000945787- Extracellular vesicles in disease
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- Circular RNAs in diseases
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Cardiac Fibrosis and Remodeling
- Photodynamic Therapy Research Studies
- Ultrasound Imaging and Elastography
- Protein Degradation and Inhibitors
- COVID-19 Clinical Research Studies
- Cardiac Structural Anomalies and Repair
- Photoacoustic and Ultrasonic Imaging
- Monoclonal and Polyclonal Antibodies Research
- Wound Healing and Treatments
- Influenza Virus Research Studies
- Dermatologic Treatments and Research
- Cardiovascular Effects of Exercise
- Cancer Research and Treatments
- Congenital heart defects research
- Skin Protection and Aging
- Mesenchymal stem cell research
Columbia University
2023-2025
Children's Hospital of Chongqing Medical University
2025
Sichuan University
2014-2025
Southwest University of Science and Technology
2025
Chongqing Medical University
2025
West China Hospital of Sichuan University
2025
North Central State College
2018-2024
North Carolina State University
2013-2024
Jinan University
2023-2024
Second Hospital of Anhui Medical University
2024
An Epidemic of Hepatitis A Attributable to the Ingestion Raw Clams in Shanghai, China Get access Mabel L. Halliday, Halliday Reprints or correspondence: Dr. Department Preventive Medicine and Biostatistics, Faculty Medicine, 4th Floor, McMurrich Bldg., 12 Queen's Park Crescent West, Toronto, Canada, M5S IA8. Search for other works by this author on: Oxford Academic PubMed Google Scholar Lai-Yi Kang, Kang Ting-Kui Zhou, Zhou Meng-Dong Hu, Hu Qi-Chao Pan, Pan Ting-Yuan Fu, Fu Yu-Sheng Huang,...
Abstract Idiopathic pulmonary fibrosis (IPF) is a fatal and incurable form of interstitial lung disease in which persistent injury results scar tissue formation. As thickens, the loses ability to facilitate gas exchange provide cells with needed oxygen. Currently, IPF has few treatment options no effective therapies, aside from transplant. Here we present series studies utilizing spheroid cell-secretome (LSC-Sec) exosomes (LSC-Exo) by inhalation treat different models fibrosis. Analysis...
Rationale: Cardiac stem cell-derived exosomes have been demonstrated to promote cardiac regeneration following myocardial infarction in preclinical studies. Recent studies used intramyocardial injection order concentrate the infarct. Though effective a research setting, this method is not clinically appealing due its invasive nature. We propose use of targeting peptide, homing peptide (CHP), target intravenously-infused infarcted heart. Methods: Exosomes were conjugated with CHP through...
Cancer is the second leading cause of death worldwide and patients are in urgent need therapies that can effectively target cancer with minimal off-target side effects.Exosomes extracellular nano-shuttles facilitate intercellular communication between cells organs.It has been established tumor-derived exosomes contain a similar protein lipid composition to secrete them, indicating might be uniquely employed as carriers for anti-cancer therapeutics.Methods: We isolated from two cell lines,...
Exosomes, as functional paracrine units of therapeutic cells, can partially reproduce the reparative properties their parental cells. The constitution exosomes, well biological activity, largely depends on cells that secrete them. We isolated exosomes from explant-derived cardiac stromal patients with heart failure (FEXO) or normal donor hearts (NEXO) and compared regenerative activities in vitro vivo. Patients FEXO group exhibited an impaired ability to promote endothelial tube formation...
Human dermal fibroblasts (HDFs), the main cell population of dermis, gradually lose their ability to produce collagen and renew intercellular matrix with aging. One clinical application for autologous trans-dermis injection HDFs that has been approved by Food Drug Administration aims refine facial contours slow down skin However, used vary in quality according state patients due many passages they undergo during expansion. In this study, factors exosomes derived from three-dimensional...
Cell therapy has been a promising strategy for cardiac repair after injury or infarction; however, low retention and engraftment of transplanted cells limit potential therapeutic efficacy. Seeding scaffold material with to create patches that are onto the surface heart can overcome these limitations. However, because need be freshly prepared maintain cell viability, long-term storage is not feasible limits clinical applicability. Here, we developed an off-the-shelf patch composed...
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has grown into a global pandemic, and only few antiviral treatments have been approved to date. Angiotensin-converting enzyme (ACE2) plays fundamental role in SARS-CoV-2 pathogenesis because it allows viral entry host cells. Here we show that ACE2 nanodecoys derived from human lung spheroid cells (LSCs) can bind neutralize protect the infection. In mice, these LSC-nanodecoys were...
Abstract Myocardial infarction, among other ischemic heart diseases, is the major cause of mortality and morbidity for patients who have diseases. Timely reperfusion myocardium most effective way to treat myocardial infarction. However, blood tissues leads an overproduction toxic reactive oxygen species (ROS), which can further exacerbate damage on top injury. ROS has been used as a diagnostic marker therapeutic target ischemia‐reperfusion (I/R) injury environmental stimulus trigger drug...
Proteolysis-targeting chimera (PROTAC) is an emerging technique for degrading disease-related proteins. However, the current PROTACs suffer from inadequate solubility and lack of organ targeting, which has hampered their druggability. Herein, we report direct sustained delivery using microneedle patches to diseased tissues. In this study, use estrogen receptor alpha (ERα)-degrading PROTAC, ERD308, treat ER-positive breast cancer. A pH-sensitive micelle, MPEG-poly(β-amino ester) (MPEG-PAE),...
Exosome therapy shows potential for cardiac repair after injury. However, intrinsic challenges such as short half-life and lack of clear targets hinder the clinical feasibility. Here, we report a noninvasive repeatable method exosome delivery through inhalation myocardial infarction (MI), which called stem cell-derived nebulization (SCENT).
Exosomes derived from dermal papilla spheroids express a high level of miR-218-5p, which directly regulates hair regeneration.
Stem cell therapies have made strides toward the efficacious treatment of injured endometrium and prevention intrauterine adhesions, or Asherman's syndrome (AS). Despite this progress, they are limited by their risk tumor formation, low engraftment rates, as well storage transportation logistics. While attempts been to curb these issues, there remains a need for simple effective solutions. A growing body evidence supports theory that delivering media, conditioned with mesenchymal stem cells,...
Acute liver failure is a critical condition characterized by global hepatocyte death and often time needs transplantation. Such treatment largely limited donor organ shortage. Stem cell therapy offers promising option to patients with acute failure. Yet, therapeutic efficacy feasibility are hindered delivery route storage instability of live products. We fabricated nanoparticle that carries the beneficial regenerative factors from mesenchymal stem cells further coated it membranes red blood...
Cardiovascular disease is the leading cause of mortality worldwide. While reperfusion therapy vital for patient survival post-heart attack, it also causes further tissue injury, known as myocardial ischemia/reperfusion (I/R) injury in clinical practice. Exploring ways to attenuate I/R interest improving post-ischemic recovery. A platelet-inspired nanocell (PINC) that incorporates both prostaglandin E2 (PGE2)-modified platelet membrane and cardiac stromal cell-secreted factors target heart...
Myocardial infarction (MI) remains the most common cause of death worldwide. Many MI survivors will suffer from recurrent heart failure (HF), which has been recognized as a determinant adverse prognosis. Despite success improved early survival after by primary percutaneous coronary intervention, HF is becoming major driver late morbidity, mortality, and healthcare costs. The development regenerative medicine brought hope to treatment in past decade. Mesenchymal stem cell (MSC)-derived...
Abstract Renal fibrosis, particularly tubulointerstitial fibrosis is considered to be the final manifestation of almost all chronic kidney diseases (CKDs). Herein we demonstrated evidence that CHOP-related ER stress associated with development renal in both CKD patients and unilateral ureteral obstruction (UUO)-induced animals, specifically, mice deficient Chop were protected from UUO-induced fibrosis. Mechanistic studies revealed loss tubular cells apoptosis secondary necrosis along...
Hypoxia can increase the resistance of tumor cells to radiotherapy and chemotherapy. However, dense extracellular matrix, high interstitial fluid pressure, irregular blood supply often serve as physical barriers inhibit penetration drugs or nanodrugs across microvessels into hypoxic regions. Therefore, it is great significance highly desirable improve efficiency hypoxia-targeted therapy. In this work, living photosynthetic bacteria (PSB) are utilized carriers for therapy due their...