A5051199839- Advanced Breast Cancer Therapies
- Cancer-related Molecular Pathways
- Parasitic infections in humans and animals
- Wound Healing and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Amoebic Infections and Treatments
- Pressure Ulcer Prevention and Management
- Cardiovascular Function and Risk Factors
- Nuclear Receptors and Signaling
- Circular RNAs in diseases
- Congenital Anomalies and Fetal Surgery
- Traditional Chinese Medicine Analysis
- TGF-β signaling in diseases
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- Urological Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Liver physiology and pathology
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Acute Kidney Injury Research
- Heart Failure Treatment and Management
- Microtubule and mitosis dynamics
- Neuroinflammation and Neurodegeneration Mechanisms
Soochow University
2016-2025
Soochow University
2025
Tongji University
2019-2025
Shanghai Tenth People's Hospital
2019-2025
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2021-2025
Chinese PLA General Hospital
2011-2025
Huaian First People’s Hospital
2021-2025
Chengdu Medical College
2018-2025
China Rehabilitation Research Center
2025
China Medical University
2014-2024
Background/Aims: Recent studies have indicated that exosomes secreted from adipose-derived stem cells (ADSCs) important effects in the treatment of ischemic injury. However, mechanism is unclear. This study aimed to investigate whether ADSC-derived enriched with microRNA (miR)-30d-5p a protective effect on acute stroke (AIS). Methods: In current study, inflammatory factors and miR-30d-5p expression were assessed 70 subjects AIS 35 healthy controls. Exosomes characterized by transmission...
Abstract Scar formation resulting from burns or severe trauma can significantly compromise the structural integrity of skin and lead to permanent loss appendages, ultimately impairing its normal physiological function. Accumulating evidence underscores potential targeted modulation mechanical cues enhance regeneration, promoting scarless repair by influencing extracellular microenvironment driving phenotypic transitions. The field appendage regeneration has witnessed remarkable advancements...
To determine the annual incidence and clinically relevant risk factors for foot ulceration in a large cohort study of diabetic ulcer (DFU) patients diabetes mellitus (DM) China. investigate 1,333 comprising 452 DFU 881 DM patients, who underwent screening, physical examination, laboratory tests eight hospitals. The were assessed at baseline terms their demographic information, medical social history, peripheral neuropathy disease (PND) periphery artery (PAD) assessment nutritional status,...
To determine incidence and clinically relevant risk factors for diabetic amputation in a large cohort study of foot ulceration patients China, we investigated total 669 patients, who were assessed at baseline demographic information, medical social history, peripheral neuropathy screening, periphery artery disease assessment nutritional status control, physical examination including deformity 15 Grade III-A hospitals. Of the 435 male 201 female, with mean age being 64.0 years. all 110 had...
Myocardial infarction (MI) remains the most common cause of death worldwide. Many MI survivors will suffer from recurrent heart failure (HF), which has been recognized as a determinant adverse prognosis. Despite success improved early survival after by primary percutaneous coronary intervention, HF is becoming major driver late morbidity, mortality, and healthcare costs. The development regenerative medicine brought hope to treatment in past decade. Mesenchymal stem cell (MSC)-derived...
Abstract Purpose: Poor prognosis in triple-negative breast cancer (TNBC) is due to an aggressive phenotype and lack of biomarker-driven targeted therapies. Overexpression cyclin E phosphorylated-CDK2 are correlated with poor survival patients TNBC, the absence CDK2 desensitizes cells inhibition Wee1 kinase, a key cell-cycle regulator. We hypothesize that expression can predict response therapies, which include kinase inhibitor, AZD1775. Experimental Design: Mono- combination therapies...
Abstract With the aging and obesity era, increasing incidence of diabetes diabetic complications, especially non‐healing wounds, imposes a serious economic burden on both patients society. The complex microenvironments, including hyperglycemia, bacterial infection, ischemia, nerve damage, lead to prolonged inflammation proliferation phase wounds. Mesenchymal stem cell‐derived small extracellular vesicles (MSC‐sEVs), which contain rich variety therapeutic molecules, have been chased for...
Abstract The gene regulatory network (GRN) plays a vital role in understanding the structure and dynamics of cellular systems, revealing complex relationships, exploring disease mechanisms. Recently, deep learning (DL)–based methods have been proposed to infer GRNs from single-cell transcriptomic data achieved impressive performance. However, these do not fully utilize graph topological information high-order neighbor multiple receptive fields. To overcome those limitations, we propose novel...
Chronic diabetic wounds are characterized by prolonged inflammation and excessive accumulation of M1 macrophages, which impede the healing process. Therefore, resolving promptly transitioning to proliferative phase critical steps for effective wound healing. Exosomes have emerged as a promising therapeutic strategy. In this study, smart hydrogel capable responding pathological cues in inflammatory microenvironment promote transition from proliferation delivering M2 macrophage-derived...
ABSTRACT Chronic cutaneous wounds represent a major health care burden in China. However, limited information exists regarding the epidemiologic changes associated with recent social and economic development. We designed cross‐sectional survey 2,513 patients who underwent treatment of chronic from nationally representative sample 17 hospitals between 2007 2008. Results revealed prevalence among hospitalized was 1.7‰. Patient ages ranged 18 days to 96 years (median, 58 years). The highest...
Clear cell renal carcinoma (ccRCC) is regarded as the most aggressive subtype of RCC, with high rates metastasis and recurrence. An extensive body studies had proved long noncoding RNAs (lncRNAs) play pivotal parts in development evolution diverse malignant tumors. However, potential LINC01094 ccRCC tumorigenesis still unexplored. In present research, aid TCGA database, we found that was highly expressed tissues. Upregulation also confirmed lines, functional experiments delineated knockdown...
Introduction: Heart failure with preserved ejection fraction (HFpEF) is associated disrupted intestinal epithelial function, resulting from congestion. Intestinal congestion changes the morphology and permeability of wall, it becomes easy for gut microbiota to change transfer. Intervention on may become a new target HFpEF treatment. However, characteristics in patients remain unknown. This preliminary report aims detect structure so as explore their characteristic changes, thereby providing...
Abstract Triple-negative breast cancer (TNBC) is an aggressive malignancy in which the tumors lack expression of estrogen receptor, progesterone and HER2. Hence, TNBC patients cannot benefit from clinically available targeted therapies rely on chemotherapy surgery for treatment. While initially responding to chemotherapy, are at increased risk developing distant metastasis have decreased overall survival compared with non-TNBC patients. A majority carry p53 mutations, enabling them bypass G1...
Dendritic epidermal T cells (DETCs) and dermal Vγ4 engage in wound re-epithelialization skin inflammation. However, it remains unknown whether a functional link between cell pro-inflammation DETC pro-healing exists to affect the outcome of closure. Here, we revealed that cell-derived IL-17A inhibited IGF-1 production by DETCs delay healing. Epidermal IL-1β IL-23 were required for suppress after injury. Moreover, clarified rather than played more important role inhibiting an NF-κB-dependent...