A5075898126- Risk and Safety Analysis
- Occupational Health and Safety Research
- Engineering Diagnostics and Reliability
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Fault Detection and Control Systems
- Corrosion Behavior and Inhibition
- Oil and Gas Production Techniques
- Drilling and Well Engineering
- Chemical Safety and Risk Management
- Respiratory Support and Mechanisms
- Carbon Dioxide Capture Technologies
- Fire Detection and Safety Systems
- Mechanical Circulatory Support Devices
- Advanced Data Processing Techniques
- Industrial Gas Emission Control
- Anesthesia and Sedative Agents
- Antifungal resistance and susceptibility
- Intensive Care Unit Cognitive Disorders
- Electrical and Bioimpedance Tomography
- Anodic Oxide Films and Nanostructures
- Ultrasound in Clinical Applications
- Transportation Safety and Impact Analysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Peking Union Medical College Hospital
2020-2025
Beijing University of Chemical Technology
2020-2024
Academy of Medical Sciences
2024
China-Japan Friendship Hospital
2020-2022
Capital Medical University
2020
National Clinical Research Center for Digestive Diseases
2020
China University of Petroleum, Beijing
2015-2019
Background: Achieving pharmacokinetic/pharmacodynamic (PK/PD) targets is critical for improving treatment success, particularly in critically ill patients. This study investigates the role of inflammatory biomarkers and their influence on PK/PD characteristics polymyxin B (PMB) patients with extensively drug-resistant Gram-negative (XDR-GN) bacterial nosocomial pneumonia. Methods: Serial blood and/or bronchoalveolar lavage fluid (BALF) samples were collected at specified time points analyzed...
Abstract The deep integration of information technology and process industry production systems makes system failure increasingly multi‐source multi‐scale. In contrast to conventional hazard methods, theoretic analysis (STPA) can analyze the hazards in control processes from perspective interactions among components. Theoretically, this method offers advantages that are better suited for modern systems. However, as now, between STPA industrial is still lacking. To address issue, study...
Little is known about the influence of extracorporeal membrane oxygenation (ECMO) on pharmacokinetics (PK) caspofungin. The aim this study was to describe population PK caspofungin in patients with and without ECMO during postoperative period lung transplantation (LTx) investigate covariates influencing PK. We compared non-ECMO patients, before after weaning as self-controls, analyzed changes Eight serial blood samples were collected from each patient for analysis. described using nonlinear...
Considering the growing emphasis on safety issues in mainland China, it is essential to identify hurdles development of disciplines and promote alignment between society. To understand current state science engineering we conducted a study while considering geographical distribution level, as well power gap universities. In terms distribution, spatial characteristics institutions with enrollment China were mapped out. illustrate existing discipline problems, situation economic production...
Pulmonary endarterectomy (PEA) is the standard treatment for chronic thromboembolic pulmonary hypertension. However, it poses risks of perioperative vascular complications, which can lead to serious clinical outcomes. This study introduces a novel noninvasive and radiation-free imaging tool, electrical impedance tomography (EIT), real-time bedside assessment lung perfusion after PEA. It identifies ventilation-perfusion mismatches arising from postoperative particularly valuable patients with...
The presence of extracorporeal membrane oxygenation (ECMO) is suggested to further exacerbate the pharmacokinetics (PK) alterations that occur during critical illness. objectives this study were determine population PK model polymyxin B in critically ill patients with or without ECMO support investigated influence on variability and identify an optimal dosing strategy.Forty-four enrolled, including eight support. Eight serial serum samples collected from each patient at steady state. was...
Abstract Objectives We aimed to assess the effectiveness and nephrotoxicity of polymyxin B in critically ill patients with nosocomial pneumonia evaluate utility its therapeutic drug monitoring (TDM). Methods retrospectively analyzed who received treatment for ≥48 h since establishment TDM a 26‐bed tertiary referral intensive care unit. Univariate multivariate analyses were conducted variables associated nephrotoxicity. Results A total 62 enrolled. Most (56.5%) performed TDM, 54.3% them...
Abstract In the petroleum and petrochemical industries, oil–water flow is widespread inside pipes. The existence of water often results in internal corrosion horizontal–vertical downward pipe when contacts wall. Surface wetting behavior wall shear stress (WSS) are two important factors affecting procedure, which governed by patterns. With propose to mitigate corrosion, focus shall be concentrated on impact pattern toward corrosion. this work, regime with investigated computational fluid...
Introduction: The most common physiological and psychological disorders associated with critical care patients are pain anxiety. Sedatives analgesics commonly used to relieve these symptoms. However, the adverse effects of sedatives inevitable. As a new type sedative drug, limited number trials available evaluate Remimazolam Besylate's availability safety compared propofol. Methods: This study is single center, randomized, open-label, controlled trial. A total 84 who meet ERAS criteria...