A5021011713- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Marine and coastal ecosystems
- Microbial Community Ecology and Physiology
- Corneal surgery and disorders
- Neuroendocrine Tumor Research Advances
- Adaptive optics and wavefront sensing
- Neuroblastoma Research and Treatments
- Optical Systems and Laser Technology
- Advanced Measurement and Metrology Techniques
- Esophageal Cancer Research and Treatment
- DNA Repair Mechanisms
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Glaucoma and retinal disorders
- Genetic factors in colorectal cancer
- Retinal Diseases and Treatments
- Gastric Cancer Management and Outcomes
- Marine and coastal plant biology
- MicroRNA in disease regulation
Second Institute of Oceanography
2025
Ministry of Natural Resources
2025
First Affiliated Hospital Zhejiang University
2021-2024
First People's Hospital of Nanning
2019-2022
Zhejiang University
2022
First Hospital of Xi'an
2019
Background Defects in replication repair-associated DNA polymerases often manifest an ultra-high tumor mutational burden (TMB), which is associated with higher probabilities of response to immunotherapies. The functional and clinical implications different polymerase variants remain unclear. Methods Targeted next-generation sequencing using a 425-cancer gene panel, covers all exonic regions three genes ( POLE , POLD1 POLH ), was conducted cohort 12,266 patients across 16 types from January...
Background: Esophageal cancer (EC) is an aggressive malignant tumor with poor prognosis and high incidence. It the sixth leading cause of cancer-related death in world, 5-year overall survival (OS) rate only 12–20%. The rapid development next-generation sequencing (NGS) has provided powerful help for treatment management EC patients.
Invasive mucinous adenocarcinoma (IMA) of the lung is a distinct histological subtype with unique clinical and pathological features. Despite previous genomic studies on IMA, genetic characteristics prognosis-related biomarkers in Chinese surgically resected IMA remain unclear.We collected 76 primary tumors invasive adenocarcinoma, including 51 25 non-mucinous adenocarcinomas (non-IMA). was further divided into pure-IMA (mucinous features≥90%) mixed-IMA subgroups. Comprehensive profiling...
Large cell neuroendocrine carcinoma (LCNEC) and classic large (LCC) are two distinct entities with different histological biological characteristics. However, the mutational profiles clinical behavior of subtypes lung cancer remain to be explored. Pathological diagnoses all screened patients were finally confirmed by three or four experienced pathologists. Patients uncertain pathological excluded. Finally, we genetically profiled ten LCNEC seven LCC. ALL subjected next-generation sequencing...
The aim of this study was to investigate the expression platelet-derived growth factor-C in aqueous humor patients with neovascular glaucoma and its correlation vascular endothelial factor.This involved 62 eyes advanced requiring transscleral cyclophotocoagulation. Aqueous collected through paracentesis. Samples from 11 age-related cataract were as control. Concentrations factor quantified by enzyme-linked immunosorbent assay. Meanwhile, correlations between concentrations analyzed. elements...
Programmed cell death 1 ligand (PD-L1) has been approved as predictive biomarker for non-small-cell lung cancer (NSCLC) patients treated with PD-(L)1 blockade therapy. The clinical/genomic features associated PD-L1 are not well studied. Genomic profiling of tumor biopsies from 883 Chinese NSCLC was performed by targeted next-generation sequencing. Immunohistochemical analysis conducted to evaluate expression levels using antibodies Dako 22C3 and 28-8, respectively. Our study showed distinct...