A5101548369- Spectroscopy and Quantum Chemical Studies
- Glaucoma and retinal disorders
- Lipid Membrane Structure and Behavior
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Surfactants and Colloidal Systems
- Angiogenesis and VEGF in Cancer
- Traumatic Ocular and Foreign Body Injuries
- Ophthalmology and Eye Disorders
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- Electrostatics and Colloid Interactions
- Retinopathy of Prematurity Studies
- Cardiovascular Health and Disease Prevention
- Intraocular Surgery and Lenses
- Corneal Surgery and Treatments
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Nanopore and Nanochannel Transport Studies
- Global Maternal and Child Health
- Antimicrobial Peptides and Activities
- Retinal and Macular Surgery
- Mass Spectrometry Techniques and Applications
- Healthcare Systems and Reforms
- Cancer-related Molecular Pathways
Shanghai Jiao Tong University
2016-2025
Shanghai University of Traditional Chinese Medicine
2022-2025
Seventh People's Hospital of Shanghai
2025
Tianjin Medical University
2025
Tianjin Medical University Eye Hospital
2025
Institute of Natural Science
2024
Sichuan University
2011-2024
Fujian Provincial Cancer Hospital
2022-2024
Fujian Medical University
2024
West China Hospital of Sichuan University
2024
Although the brain comprises only 2% of body weight, it receives 15% cardiac output and consumes 20% total oxygen delivered through its blood vasculature. The vasculature consists a highly branched vessel network that is tailored to efficiently deliver nutrients each region. However, little known about how develops. Using in vivo long-term serial confocal imaging zebrafish larvae, we analyze this process find developing midbrain undergoes not growth but also flow-driven pruning. We show...
It has been hypothesized that topological structures of biological transport networks are consequences energy optimization. Motivated by experimental observation, we propose adaptation dynamics may underlie this In contrast to the global nature optimization, our responds only local information and can naturally incorporate fluctuations in flow distributions. The minimizes consumption produce optimal networks, which possess hierarchical loop presence strong distribution. We further show there...
Abstract Many antimicrobial peptides (AMPs) selectively target and form pores in microbial membranes. However, the mechanisms of membrane targeting, pore formation function remain elusive. Here we report an experimentally guided unbiased simulation methodology that yields mechanism spontaneous assembly for AMP maculatin at atomic resolution. Rather than a single pore, forms ensemble structurally diverse temporarily functional low-oligomeric pores, which mimic integral protein channels...
Abstract Background Metformin, which is widely used as an antidiabetic agent, has recently been reported to reduce cancer risk and improve prognosis in certain malignancies. However, the specific mechanisms underlying effect of metformin on development progression several cancers including oral squamous cell carcinoma (OSCC) remain unclear. In present study, we investigated effects OSCC cells vitro vivo . Methods treated with or without were counted using a hemocytometer. The clonogenic...
Surface tension (ST) has been the most important measure of a molecule's surface activity. However, in many cases complex behaviors ST are challenging to interpret. For example, aqueous solutions sodium docecyl sulfate (SDS) and poly(diallyldimethylammonium chloride) (PDADMAC) show dramatic changes when concentration SDS varies. Although surfactants generally described as "substances that reduce tension", new evidence shows may have little significant amount is present at water surface. The...
Abstract Drug development for the treatment of central nervous system (CNS) diseases is extremely challenging, in large part due to difficulty crossing blood-brain barrier (BBB). Here we develop and experimentally validate a new silico method predict quantitatively BBB permeability small-molecule drugs. We show accurate prediction solute permeabilities at physiological temperature using high-temperature unbiased atomic detail molecular dynamics simulations spontaneous drug diffusion across...
To assess the endothelial toxicity and microbiological efficacy of voriconazole (100 microg/mL) as an antimicrobial additive to Optisol GS.A total 533 donor rims were studied. One half each rim was placed in standard GS other fortified with microg/mL). All refrigerated for 24 hours at 3 degrees C thioglycolate broth incubated 37 7 days. A pair buttons not used transplantation stored 2 days solution examined changes electron microscopy (EM). second cornea by staining 0.3% trypan blue 0.2%...
Interactions of the polyelectrolyte partially hydrolyzed polyacrylamide (HPAM) with water and cations at air/liquid interfaces were studied using phase-sensitive sum frequency generation (SFG) vibrational spectroscopy. In contrast to conventional SFG spectroscopy which measures only amplitude second-order susceptibility |χ(2)|, heterodyne-detected complex χ(2) contains information about absolute orientation surface molecules. While OH groups near a neat air/water interface mostly pointed...
<i>Background:</i> Vascular endothelial growth factor (VEGF) is upregulated by hypoxia and a major stimulatory for choroidal neovascularization. The upregulation of VEGF expression in response to occurs through hypoxia-inducible 1 (HIF-1), which transcription that regulates genes involved the hypoxia. HIF-1α inducible subunit HIF-1. <i>Aims:</i> To further define HIF-1 function angiogenesis explore novel approaches modulate neovascularization age-related macular...
Small ubiquitin-like modifier (SUMO) modification is an important post-translational protein that can be reversed by SUMO-specific proteases (SENPs); however, the physiological function of SENPs remains largely unexplored, and little known about regulation themselves. As one crucial members SUMO system, SENP3 essential for rRNA processing cell proliferation. In present study, we analysed expression in human oral squamous carcinoma (OSCC) investigated correlation between its...
We carried out a combined study using surface tension, phase-sensitive frequency generation (SFG) vibrational spectroscopy, and MD simulations to investigate the industrially relevant zwitterionic surfactant N-dodecyl-N, N-dimethyl-3-ammonio-1-propanesulfonate (DDAPS) on water surface. The SFG Im(χ(2)) spectra showed that interaction between DDAPS was different from those biologically phospholipids water. While were found be anionic-like flipped molecules with their OHs pointing toward air,...
In the modeling of pulse wave in systemic arterial tree, it is necessary to truncate small crowns representing networks arteries and arterioles. Appropriate boundary conditions at truncation points are required represent reflection effects truncated crowns. this work, we provide a systematic method extract parameters three-element Windkessel model from impedance tree or experimental measurements blood pressure flow rate inlet crown. addition, propose an improved with complex capacitance...
Throughout the life of animals and human beings, blood vessel systems are continuously adapting their structures – diameter lumina, thickness walls, number micro-vessels to meet changing metabolic demand tissue. The competition between an ever decreasing tendency luminal diameters increasing stimulus from wall shear stress plays a key role in adaptation diameters. However, it has been shown previous studies that dynamics based only on these two effects is unstable. In this work, we propose...
It is common knowledge that surfactants lower the surface tension of water. The typical textbook explanation this phenomenon force attraction between surfactant and water molecules less than two molecules; hence contraction decreases in presence surfactants; however, description, based on strength intermolecular interactions, overly simplified because it ignores an important thermodynamic function: entropy Here we report separate measurements water’s enthalpy nonionic, zwitterionic, anionic,...
To analyze the effects of neuroendoscopic minimally invasive surgery and small bone window craniotomy hematoma clearance through comparing clinical indicators two operation modes to provide a reference for selection proper surgery.One hundred twenty-six patients with hypertensive cerebral hemorrhage who received diagnosis treatment in our hospital between December 2015 2017 were selected grouped into an observation group (n=63) control using random number table. Patients treated by surgery,...
Objective This study aimed to investigate the prevalence of glaucoma with associated factors in rural populations 10 provinces China. Design A population-based cross-sectional study. Methods All participants aged 6 years or older from completed visual acuity testing, slit-lamp examination, ophthalmoscopy and non-contact tonometry. Glaucoma suspects underwent fundus photography, Goldmann applanation tonometry, field testing gonioscopy. was determined according International Society...
Background Since 2010, China has implemented a national programme to train general practitioners for rural areas. The enrolled medical students with background who signed contract 6 years' compulsory service after graduation. is transitioning its COVID-19 strategies in view of the features coronavirus Omicron variant, vaccination coverage, and need socioeconomic development. Strengthening primary health care, especially workforce areas, should be an important consideration during policy...