A5044416117- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Cancer Genomics and Diagnostics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Immune cells in cancer
- Neuroendocrine Tumor Research Advances
- Esophageal Cancer Research and Treatment
- Circadian rhythm and melatonin
- Immune Cell Function and Interaction
- AI in cancer detection
- Ferroptosis and cancer prognosis
- Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Quinazolinone synthesis and applications
Shanghai Chest Hospital
2019-2025
Shanghai Jiao Tong University
2021-2025
Lishui City People's Hospital
2024
Fudan University
2016
Shanghai Medical College of Fudan University
2012
Abstract An immunosuppressive microenvironment enriched with regulatory CD4 + T lymphocytes (Tregs) facilitates the progression of lung adenocarcinoma (LUAD). This study aims to investigate cellular mechanism underlying formation in LUAD. LUAD samples ( n = 12) and normal 3) were obtained from patients different pathological stages Single-cell RNA sequencing was performed classify components analyze transcriptomes, including transcription factors/targets chemokine ligands/receptors, followed...
Background. The risk of atherosclerosis is elevated in abnormal lipid metabolism and circadian rhythm disorder. We investigated whether lighting condition would have influenced the expression clock genes clock-controlled metabolism-related ApoE-KO mice. Methods. A mouse model with disorder was established using mice (ApoE-KO LD/DL mice) by altering exposure to light. C57 BL/6J (C57 exposed normal day night diet served as control According zeitgeber time samples were acquired, test...
Lung adenocarcinoma (LUAD) is a heterogeneous disease. Our study aimed to understand the unique molecular features of preinvasive invasive LUAD subtypes. We retrospectively analyzed clinical, histopathological, and data 3,254 Chinese patients with lesions (n = 252), minimally adenocarcinomas 479), 2,523). Molecular were elucidated using targeted 68-gene next-generation sequencing panel. findings revealed four lesion-predominant gene mutations, including MAP2K1 insertion-deletions (indels),...
To describe the histologic features of bronchiolar adenoma/ciliated muconodular papillary tumors (BA/CMPTs) and analyze pitfalls in diagnosis from frozen sections. A total 208 permanent sections BA/CMPTs Shanghai Chest Hospital July 2018 to 2021 were retrospectively analyzed. The median age BA/CMPT patients was 65 years (15 79 y), women accounted for 61.62% (122/198). size 0.6 cm (range 0.2 2 cm), which 88.94% small (≤1 cm, 185/208). In terms location, right lower lobe 44.23% (92/208), left...
Abstract The molecular profile of neurotrophic tyrosine kinase receptor ( NTRK ) gene fusions in lung adenocarcinoma (LUAD) is not fully understood. Next‐generation sequencing (NGS) and pan‐tyrosine (TRK) immunohistochemistry (IHC) are powerful tools for fusion detection. In this study, a total 4,619 LUAD formalin‐fixed, paraffin‐embedded tissues were collected from patients who underwent biopsy or resection at the Shanghai Chest Hospital during 2017–2019. All specimens screened NTRK1...
Abstract The genomic origin and development of the biphasic lung adenosquamous carcinoma (ASC) remain inconclusive. Here, we derived potential evolutionary trajectory ASC through whole-exome sequencing, Stereo-seq, patient-derived xenografts. We showed that EGFR MET activating mutations were main drivers in ASCs. Phylogenetically, these passenger found both components trunk clonal events, confirming monoclonal origination. Comparison multiple lesions also revealed closer distance between...
The growing application of immune checkpoint inhibitors (ICIs) in cancer immunotherapy has underscored the critical need for reliable methods to identify patient populations likely respond ICI treatments, particularly lung treatment. Currently, tumor proportion score (TPS), a crucial biomarker selection, relies on manual interpretation by pathologists, which often shows substantial variability and inconsistency. To address these challenges, we innovatively developed multi-instance learning...
e20030 Background: Tumoral heterogeneity has been widely acknowledged to influence clinical outcome of lung adenocarcinoma (LUAD). This study investigated spatial gene profiling different pathological subtypes early-stage invasive LUAD with Stereo-seq transcriptomics technique. The tumor microenvironment (TME) was decoded cellular and molecular events at perspectives tumoral activities immune activities. Methods: We collected RNA profiles nine chips (captured area 1 x1 cm) from 4 patients....
Abstract Background Dysregulation of circadian rhythms can contribute to diseases lipid metabolism. NAD-dependent deacetylase sirtuin-1(SIRT1) is an important hub which links metabolism with clock by its deacetylation activity depends on intracellular NAD + /NADH content ratio. Hydrogen sulfide (H 2 S) endogenous reductant affect the redox state. Therefore, we hypothesized that exogenous H S expression genes mediated sirt1 thereby affecting body's And also because liver a typical peripheral...
An increasing number of small pulmonary nodules are being screened by CT, and an intraoperative diagnosis is necessary for preventing excessive treatment. However, there limited literature on the frozen sclerosing pneumocytomas (SPs). In particular, tumours smaller than 1 cm challenging pathologists performing diagnosis.In total, 230 cases SP were surgically resected between January 2015 March 2019 at Shanghai Chest Hospital, them, 76 cm. The histology clinical information these (33.0%,...
Background Different pathological subtypes of lung adenocarcinoma lead to different treatment decisions and prognoses, it is clinically important distinguish invasive from preinvasive (adenocarcinoma in situ minimally adenocarcinoma). This study aims investigate the performance deep learning approach based on high-resolution computed tomography (HRCT) images classification tumor invasiveness compare with performances currently available approaches. Methods In this study, we used a 3D...
Abstract The authors have requested that this preprint be removed from Research Square.
In recent years, there have been numerous studies using Quality Intima-Media Thickness (QIMT) and Quantitative Arterial Stiffness (QAS) technology to evaluate various related factors disease-induced changes in carotid artery (CA) elasticity. However, is still a lack of research on the relationship between non-alcoholic fatty liver disease (NAFLD) indicators CA. This study aimed investigate clinical significance QIMT QAS techniques for comprehensive evaluation CA intima-media thickness (IMT)...
Abstract Background: Anti-programmed cell death protein 1/programmed ligand 1 (anti-PD1/PDL1) based immunotherapy is the standard first-line treatment for advanced NSCLC patients without targetable driver mutations, but PDL1 immunohistochemistry (IHC) shows limited predictive value as companion diagnostics. Recent studies have elucidated a strong relationship between efficacy and tumor immune microenvironment (TIME) using single-cell multi-omics technology. In this study, we aim to develop...
To investigate the clinicopathological features and differential diagnosis of primary pulmonary hyalinizing clear cell carcinoma (HCCC), as well its diagnostic pitfalls in assessing biopsy specimens.
9051 Background: Lung adenocarcinoma (LUAD) is further classified into several histological subtypes with in situ (AIS), minimally invasive (MIA), and (IAC) as the three major according to extent of invasion. AIS has been considered a precursor IAC. Considering significantly higher mutation burden among IAC tumors than tumors, it seems likely that undergo process accumulating various somatic mutations gain ability. To understand gene involved this transformation, we compared mutational...
Abstract Background: Different pathological subtypes of lung adenocarcinoma lead to different treatment decisions and prognoses, it is clinically important distinguish invasive from preinvasive (adenocarcinoma in situ minimally adenocarcinoma). This study aims investigate the performance deep learning approach on classification tumor invasiveness compare with performances currently available approaches. Methods: In this study, we propose a based 3D conventional networks automatically predict...
Abstract Background Different pathological subtypes of lung adenocarcinoma lead to different treatment decisions and prognoses, it is clinically important distinguish invasive from preinvasive (adenocarcinoma in situ minimally adenocarcinoma). This study aims investigate the performance deep learning approach on classification tumor invasiveness compare with performances currently available approaches. Methods In this study, we propose a based 3D conventional networks automatically predict...