A5023550857- ZnO doping and properties
- Gas Sensing Nanomaterials and Sensors
- Ga2O3 and related materials
- Copper-based nanomaterials and applications
- Bacterial Genetics and Biotechnology
- Bacterial biofilms and quorum sensing
- Semiconductor materials and devices
- Advancements in Battery Materials
- Corrosion Behavior and Inhibition
- Silicon Carbide Semiconductor Technologies
- Thin-Film Transistor Technologies
- Catalytic Processes in Materials Science
- Supercapacitor Materials and Fabrication
- Transition Metal Oxide Nanomaterials
- Advanced Fiber Optic Sensors
- Vibrio bacteria research studies
- Advanced Fiber Laser Technologies
- Advanced Photocatalysis Techniques
- MXene and MAX Phase Materials
- Metal and Thin Film Mechanics
- Silicon and Solar Cell Technologies
- Magnesium Alloys: Properties and Applications
- Microbial Community Ecology and Physiology
- Catalysts for Methane Reforming
- Advancements in Solid Oxide Fuel Cells
Peking University
2025
Peking University Cancer Hospital
2025
Northeastern University
2022-2024
Xi'an Technological University
2007-2024
China University of Geosciences
2023
China University of Petroleum, East China
2022
657 Oslo
2020-2021
Enrico Fermi Center for Study and Research
2020-2021
CeNTI (Portugal)
2021
University of Oslo
2014-2021
Phages are the most abundant entity in biosphere and outnumber bacteria by a factor of 10. Phage DNA may also constitute 20% bacterial genomes; however, its role is ill defined. Here, we explore impact cryptic prophages on cell physiology precisely deleting all nine prophage elements (166 kbp) using Escherichia coli. We find that contribute significantly to resistance sub-lethal concentrations quinolone β-lactam antibiotics primarily through proteins inhibit division (for example, KilR rac...
This open-label phase II trial (NCT04542837) aimed to evaluate the efficacy and safety of KN046 combined with lenvatinib in patients advanced hepatocellular carcinoma (HCC), explore potential response biomarkers. Participants received 5 mg/kg every 3 weeks 12 or 8 mg once daily. The primary endpoints were safety, tolerability, dose-limiting toxicity (DLT), objective rate (ORR) according RECIST v1.1. A total fifty-five participants enrolled. results meet pre-specified endpoints. No DLT was...
The roles of toxin-antitoxin (TA) systems in bacteria have been debated. Here, the role five TA regard to biofilm development was investigated (listed as toxin/antitoxin: MazF/MazE, RelE/RelB, ChpB, YoeB/YefM, and YafQ/DinJ). Although these multiple were reported previously not impact bacterial fitness, we found that deletion decreased formation initially (8 h) on three different surfaces then increased (24 by decreasing dispersal. Whole-transcriptome profiling revealed induced expression a...
Summary Previously we discovered that OmpA of Escherichia coli increases biofilm formation on polystyrene surfaces ( González Barrios et al ., Biotechnol Bioeng , 93:188–200, 2006a ). Here show influences differently hydrophobic and hydrophilic since it represses cellulose production which is hydrophilic. increased polystyrene, polypropylene, polyvinyl while decreased glass surfaces. Sand column assays corroborated decreases attachment to The ompA mutant formed sticky colonies, the...
Summary Bacteria prefer to grow attached themselves or an interface, and it is important for array of applications make biofilms disperse. Here we report simultaneously the discovery protein engineering BdcA (formerly YjgI) biofilm dispersal using universal signal 3,5‐cyclic diguanylic acid (c‐di‐GMP). The bdcA deletion reduced dispersal, production increased wild‐type level. Since increases motility extracellular DNA while decreasing exopolysaccharide, cell length aggregation, reasoned that...
The specific monitoring of physiological highly reactive oxygen species (hROS) using fluorescent gold nanoclusters (AuNCs) remains a challenge for scientists. Herein, SLB-AuNC was first synthesized via an ecofriendly one-pot method starch as template, l-3,4-dihydroxyphenylalanine (l-DOPA) reducing and capping agent, boric acid protecting agent the catechol moiety l-DOPA. ingenious introduction enhanced dispersibility, quantum yield, photostability SLB-AuNCs. obtained SLB-AuNCs possessed good...
ABSTRACT Differential gene expression in biofilm cells suggests that adding the derepressed conjugative plasmid R1 drd 19 increases formation by affecting genes related to envelope stress ( rseA and cpxAR ), bssR cstA energy production glpDFK acid resistance gadABCEX hdeABD cell motility csgBEFG, yehCD, yadC , yfcV ); encoding outer membrane proteins ompACF phage shock pspABCDE cold cspACDEG phage-related genes. To investigate link between identified upon addition of 19, 40 isogenic mutants...
Previously we showed that BdcA controls Escherichia coli biofilm dispersal by binding the ubiquitous bacterial signal cyclic diguanylate (c-di-GMP); upon reducing concentration of c-di-GMP, cell shifts to planktonic state increasing motility, decreasing aggregation, and production adhesins.Here report also increases in other Gram-negative bacteria including Pseudomonas aeruginosa, fluorescens, Rhizobium meliloti. binds c-di-GMP these strains thereby reduces effective concentrations as...