A5101979343- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Climate Change and Health Impacts
- Protein Structure and Dynamics
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Chromatin Remodeling and Cancer
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- RNA and protein synthesis mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Research Studies
- Patient Satisfaction in Healthcare
- Lung Cancer Diagnosis and Treatment
- Sphingolipid Metabolism and Signaling
- Erythrocyte Function and Pathophysiology
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Patient-Provider Communication in Healthcare
- Colorectal Cancer Screening and Detection
- Inertial Sensor and Navigation
- GNSS positioning and interference
- Indoor Air Quality and Microbial Exposure
- Enzyme Structure and Function
- Air Quality and Health Impacts
Beijing Institute of Technology
2025
Capital University
2025
Capital Medical University
2025
First Hospital of Lanzhou University
2024
Hangzhou Normal University
2022-2024
Huazhong University of Science and Technology
2005-2024
Lanzhou University
2024
Fujian Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Peking Union Medical College Hospital
2024
Tumor cell-derived extracellular vesicles (tEVs) have garnered significant attention as promising antigen delivery vehicles for the development of cancer vaccines. However, their practical applications are hindered by weak immunogenicity and inadequate lymph node targeting. In this study, we engineered tEVs into "self-adjuvant" multiantigenic nanovaccines that simultaneously accumulate in tumors nodes (LNs), effectively triggering innate adaptive immunity capable recognizing both tumor cells...
Background FBXW7 is recognized as a critical tumor suppressor gene and component of the ubiquitin-proteasome system, mediating degradation multiple oncogenic proteins, including c-MYC, Cyclin E, c-Jun, Notch, p53. Around 16% colorectal cancer (CRC) patients carried somatic mutations, while comprehensive characterization mutations in CRC still lacking. Methods Colorectal with samples matching white blood cell past five years were screened DNA sequenced. sequencing data MSK MetTropism cohort...
ROS1 fusion-positive (ROS1+) nonsmall cell lung cancer (NSCLC) patients are highly sensitive to tyrosine kinase inhibitor (TKI) treatments. However, acquired TKI resistance remains the major hurdle preventing from experiencing prolonged benefits.
Background Metagenomic next-generation sequencing (mNGS) is a powerful method for pathogen detection in various infections. In this study, we assessed the value of mNGS diagnosis and microbiome analysis pneumonia pediatric intensive care units (PICU) using bronchoalveolar lavage fluid (BALF) samples. Methods A total 104 patients with who were admitted into PICU between June 2018 February 2020 retrospectively enrolled. Among them, 101 subjects had intact clinical information subject to...
<title>Abstract</title> Background Hypertension is a leading modifiable risk factor for stroke, which important the Group of 20 (G20) countries facing heavy hypertension and stroke prevalence. This study aims to quantify hypertension-related burden subtypes, including ischemic (IS), intracerebral hemorrhage (ICH), subarachnoid (SAH) across G20 from 1990 2021 project trends 2050. Methods The utilized data GBD assess disability-adjusted Life years (DALYs) deaths IS, ICH, SAH. future was...
Abstract The micropapillary (MIP) pattern is a high‐grade histological subtype of lung adenocarcinoma (LUAD) with poor prognosis. In this study, surgically resected tumor samples from 101 patients stage I–III MIP–LUAD (MIP ≥30%) were microdissected to separate MIP components non‐MIP components, all which underwent RNA and DNA whole‐exome sequencing (WES). genomic transcriptomic landscapes within MIP‐enriched tissues demonstrated remarkable similarities, notably marked by high epidermal...
Abstract Background: TP53 gain-of-function (GOF) effects lead to cellular responses beyond the capabilities of wild-type and are known promote cancer progression tumor growth. Clinical studies linked GOF mutations poorer outcomes in high-methylated metastatic colorectal advanced pancreatic ductal adenocarcinoma, while their impact on lung remains unclear. Methods: A total 486 patients diagnosed with non-small cell (NSCLC) baseline DNA sequencing data were enrolled. from external two NSCLC...
Introduction In this study, we investigated the differences in clinical outcomes following endovascular thrombectomy among ischemic stroke subtypes caused by large artery atherosclerosis (LAA) versus cardioembolism (CE) and time-dependent nature of these based on subtypes. Methods: Study participants were selected from Endovascular Treatment Key Technique Emergency Workflow Improvement Acute Ischemic Stroke Registry to conduct a post-hoc analysis prospective, observational study. We included...
Recent studies have reported an increasing incidence of ischemic stroke, particularly in younger age groups. Dental pulp stem cells (DPSCs) and periodontal ligament (PDLSCs) are the most common acquired from teeth adults, even elderly people. However, there no detailed reports on whether DPSCs or PDLSCs suitable for treatment stroke. In this study, vitro differentiation into neuron-like was evaluated. Then, we established a rat model cerebral ischemia. were administered to animals,...
SMARCA4-deficient undifferentiated uterine sarcoma (SDUS) is a highly invasive single-gene malignant tumor caused by mutations in the SMARCA4 gene. SDUS has poor prognosis, with no established treatment strategy at present. Further, there lack of relevant research on role immune microenvironment worldwide. Here, we report case that was diagnosed and analysed using morphological, immunohistochemical, molecular detection techniques, along analysis microenvironment. By immunohistochemistry,...
Deep learning methods, especially convolutional neural network (CNN), which have made breakthroughs in many fields of computer vision, and one the most prominent features deep is that large-scale dataset with annotations should be used. However, obtaining such a medical field really challenge due to scarcity annotated data. In our work, based framework proposed generate more real data from existing Generative Adversarial Networks (GAN) classify suspicious lesions CNN. The method applied on...
Cancer is one of the leading causes death in world. Various drugs have been developed to eliminate it but no avail because a tumor can go into dormancy avoid therapy. In past few decades, has become popular topic cancer Recently, there an important breakthrough study dormancy. That is, cells enter reversible drug-tolerant persister (DTP) state therapy, exact mechanism found. The link between DTP and diapause seems provide opportunity for correct understanding state. Completely treating...
Patient satisfaction reflects the social benefits of hospitals and is an important indicator hospital performance. This study explores mechanism through which inpatients' trust in physicians, self-efficacy, participation medical decision-making impact their with services.
The incidence of multiple primary lung cancer (MPLC) is increasing, with some our surgical patients exhibiting numerous lesions. We defined five or more lesions as super MPLCs. Elucidating the genomic characteristics this special MPLC subtype can help reduce disease burden and understand tumor evolution. In cohort synchronous early-stage MPLCs (PUMCH-ssesMPLC), whole-exome sequencing on 130 resected malignant specimens from 18 provided comprehensive super-MPLC landscapes. Mutations are...
We investigated the effects of cold and hot seasons on hospital admissions for acute myocardial infarction (AMI) at junction tropical subtropical climate zones. The hospitalization data 6897 AMI patients from January 1997 to December 2011 were obtained database National Health Insurance, including date admission, gender, age, comorbidities hypertension, diabetes mellitus (DM), dyslipidemia. A comparison prevalence between association season-related occurrences with individual variables...
Gastric cancer is one of the most common and deadly types worldwide, which brings millions dollars economic loss each year. Patients diagnosed with early-onset gastric were reported to have a worse prognosis compared other patients, while mechanisms behind such phenomenon are unknown. To identify age-dependent somatic alternations in cancer, next-generation sequencing targeting 425 genes was performed on 1688 tumor tissues corresponding plasma samples. In our study, microsatellite...
Lung cancer is the deadliest and most diagnosed type of worldwide. The 5-year survival rate lung adenocarcinoma (LUAD) dropped significantly when tumor stages advanced. Patients who received surgically resecting at pre-invasive stage had a nearly 100%. However, study on differences in gene expression profiles immune microenvironment among LUAD patients still lacking.In this study, three were compared using RNA-sequencing data 10 situ (AIS) samples, 12 minimally invasive (MIA) (IAC)...
Abstract Here, we first report a case of neoadjuvant ceritinib for locally advanced lung adenosquamous carcinoma. In this study, carcinoma (ASC) patient with EML4‐ALK fusion who achieved partial response treatment after cycle chemotherapy did not show significant efficacy. A complete surgical resection was performed mild adhesions and small amount bleeding intraoperatively. The detected by targeted next‐generation sequencing (NGS) in both pretreatment biopsy the postoperative tissue...
Background Patient-centered care (PCC) is globally recognized as a high-quality and high-value healthcare service. It emphasizes the broad participation of patients families in health-related decision-making provision services that cater to patients' needs, preferences, values. However, mechanisms driving workers' PCC are yet be fully uncovered. Methods Using stratified random sampling, we recruited 1,612 workers from different levels public hospitals Hangzhou. We conducted survey interviews...