A5102990560- Metal and Thin Film Mechanics
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- SARS-CoV-2 and COVID-19 Research
- Intermetallics and Advanced Alloy Properties
- Electrochemical Analysis and Applications
- Graphene research and applications
- Plant tissue culture and regeneration
- Advanced ceramic materials synthesis
- Thermochemical Biomass Conversion Processes
- Insect Resistance and Genetics
- Nosocomial Infections in ICU
- Advancements in Battery Materials
- Carbon Nanotubes in Composites
- Transgenic Plants and Applications
- Electrocatalysts for Energy Conversion
- Chronic Kidney Disease and Diabetes
- Carbon and Quantum Dots Applications
- GaN-based semiconductor devices and materials
- Conducting polymers and applications
- Plant Stress Responses and Tolerance
Children's Hospital of Fudan University
2021-2025
First Affiliated Hospital of Zhengzhou University
2021-2025
Chang'an University
2024
Ministry of Water Resources of the People's Republic of China
2024
Zhongyuan University of Technology
2022-2024
Shanghai University of Engineering Science
2019-2024
Center for Children
2024
Chinese Academy of Sciences
2011-2023
Beijing Normal University
2023
Peking University
2018-2023
Abstract Chronic kidney disease (CKD) has historically been a significant global health concern, profoundly impacting both life and well-being. In the process of CKD, with gradual loss renal function, incidence various life-threatening complications, such as cardiovascular diseases, cerebrovascular accident, infection stroke, is also increasing rapidly. Unfortunately, existing treatments exhibit limited ability to halt progression injury in emphasizing urgent need delve into precise...
Abstract Background Antimicrobial resistance (AMR) is a major threat to children’s health, particularly in respiratory infections. Accurate identification of pathogens and AMR crucial for targeted antibiotic treatment. Metagenomic next-generation sequencing (mNGS) shows promise directly detecting microorganisms genes clinical samples. However, the accuracy prediction through mNGS testing needs further investigation practical decision-making. Methods We aimed evaluate performance predicting...
In plants, CuZn superoxide dismutase (CuZnSOD, EC l.15.1.1), ascorbate peroxidase (APX, 1.11.1.11), and catalase (CAT, l.11.1.6) are important scavengers of reactive oxygen species (ROS) to protect the cell from damage. present study, we isolated three homologous genes (GhSOD1, GhAPX1, GhCAT1) Gossypium hirsutum. Overexpressing cassettes containing chimeric GhSOD1, or GhCAT1 were introduced into cotton plants by Agrobacterium transformation, overexpressed products these transported...
Bloodstream infection is a life-threatening complication in critically ill patients. Multi-drug resistant bacteria or fungi may increase the risk of invasive infections hospitalized children and are difficult to treat intensive care units. The purpose this study was use metagenomic next-generation sequencing (mNGS) understand bloodstream microbiomes with suspected sepsis pediatric unit (PICU). mNGS were performed on microbial cell-free nucleic acid from 34 admitted PICU, potentially...
This study aimed to understand the epidemiological and clinical characteristics of pediatric SARS-CoV-2 infection during early stage Omicron variant outbreak in Shanghai.This included local COVID-19 cases <18 years Shanghai referred exclusively designated hospital from March 7 31, 2022. Clinical data, exposure, vaccination status were collected. Relative risks (RRs) calculated assess effect on symptomatic febrile disease.A total 376 (median age: 6.0 ± 4.2 years) hospital, including 257...
Background Severe pneumonia due to lower respiratory tract infections (LRTIs) is a significant cause of morbidity and mortality in children. Noninfectious syndromes resembling LRTIs can complicate the diagnosis may also make targeted therapy difficult because difficulty identifying LRTI pathogens. In present study, highly sensitive metagenomic next-generation sequencing (mNGS) approach was used characterize microbiome bronchoalveolar lavage fluid (BALF) children with severe identify...
Background Metagenomic next-generation sequencing (mNGS) is a powerful method for pathogen detection in various infections. In this study, we assessed the value of mNGS diagnosis and microbiome analysis pneumonia pediatric intensive care units (PICU) using bronchoalveolar lavage fluid (BALF) samples. Methods A total 104 patients with who were admitted into PICU between June 2018 February 2020 retrospectively enrolled. Among them, 101 subjects had intact clinical information subject to...
Abstract Background and Objectives Diabetic kidney disease (DKD) is one of the most common microvascular complications diabetes. It has always been difficult to explore novel biomarkers therapeutic targets DKD. We aimed identify new further their functions in Methods The weighted gene co-expression network analysis (WGCNA) method was used analyze expression profile data DKD, obtain key modules related clinical traits perform enrichment analysis. Quantitative real-time polymerase chain...
Objectives This study aimed to identify novel, non-invasive biomarkers for lupus nephritis (LN) through serum proteomics. Methods Serum proteins were detected in patients with LN and healthy control (HC) groups liquid chromatography-tandem mass spectrometry. The key networks associated screened out using Cytoscape software, followed by pathway enrichment analysis. best candidate selected machine learning models, further validated a larger independent cohort. Finally, the expression of these...
Study on the clinical pathogen diagnosis in large cohort of critically ill children using metagenomic next-generation sequencing (mNGS) with different enrichment strategies has been limited. 763 samples were enrolled and we summarized compared performance between mNGS microbial tests (CMTs) sample types, as well shotgun-based (S-mNGS) hybrid capture-based (C-mNGS). A total 93 diagnosed pathogens identified from763 suspected infections, a positive rate 60.16 %. Respiratory specimens had...
The development of high reflection loss and broad frequency bandwidth for electromagnetic wave absorbing materials has been pursued a long time.
Plant genetic transformation has arguably been the core of plant improvement in recent decades. Efforts have made to develop planta systems due limitations present tissue-culture-based methods. Herein, we report an improved system, and provide evidence reporter gene expression pollen tube, embryos stable transgenicity plants following pollen-mediated with optimized sonication treatment pollen. The results showed that aeration at 4°C grains sucrose prior significantly viability leading kernel...
Abstract Supercritical water gasification of lignite with KOH was investigated in a batch autoclave on wide range conditions, that is residence time (5–30 min), mass ratio H 2 O to (0.5–10), temperature (400–600°C) and (0–20%). Although difficult be gasified supercritical water, the results indicated efficiency about 47% achieved at 30 min, 550°C 10% KOH. Higher can lead higher gas yields GE. It also observed solid residue dispersed low feed concentration consolidated high concentration....
What is known and Objective Meropenem, a broad-spectrum carbapenem, frequently used to treat severe bacterial infections in critically ill children. Recommendations for meropenem doses adult are available; however, few studies have been published regarding the use of children with sepsis, especially those receiving continuous renal replacement therapy (CRRT) extracorporeal membrane oxygenation (ECMO). We aimed investigate pharmacokinetic (PK) parameters sepsis life support (ECLS). Methods...