A5017330670- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Genetic factors in colorectal cancer
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Advanced Radiotherapy Techniques
- Neuroscience and Neuropharmacology Research
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Extracellular vesicles in disease
- RNA modifications and cancer
- Cancer Diagnosis and Treatment
- Electric Vehicles and Infrastructure
- Head and Neck Cancer Studies
iCo Therapeutics (Canada)
2025
Peking University
2010-2023
Peking University Cancer Hospital
2010-2023
China Electric Power Research Institute
2022-2023
North China Electric Power University
2022
Northeastern University
2022
Changsha Central Hospital
2022
Genesee Community College
2022
EY Technologies (United States)
2022
University of Science and Technology of China
2012-2019
Background Immunotherapy has become an important treatment option for patients with advanced non-small cell lung cancer (NSCLC). At present, none of these existing biomarkers can effectively stratify true responders and there is urgent need identifying novel biomarkers. Exosomes derived from the serum have been proven to be reliable markers diagnosis. Here, we explored possibility using plasma-derived exosomal microRNAs as potential optimal selection EGFR/ALK negative NSCLC immunotherapy....
The present study aimed to prospectively evaluate the role of metagenomic next-generation sequencing (mNGS) in etiological diagnosis patients with perioperative infective endocarditis (IE).From May 1st, 2019 December 31st, 2020, a total 99 IE were enrolled according modified Duke criteria, etiological, and pathological results. 11 non-IE undergoing heart valve surgery same period selected as control group. A blood culture test was performed immediately after admission, valves harvested...
Abstract Background Gastric cancer (GC) is confronted with limited options for precision medicine. Human epidermal growth factor receptor 2 (HER2) the principal druggable target of GC, yet proper biomarkers response/resistance prediction remain unveiled. Methods From 40 GC patients received HER2‐targeted therapy, a total 327 peripheral blood plasma specimens was collected including baseline and treatment time points. Circulating tumor DNA (ctDNA) extracted sequenced panel 425 genes....
Histone methylation performs multiple functions such as DNA replication, transcription regulation, heterochromatin formation, and chromatin condensation. How this gradient is orchestrated in the centromere during chromosome segregation not known. Here we examine temporal dynamics of protein by SUV39H1 methyltransferase, a key mitotic regulator, using fluorescence resonance energy transfer-based sensors living HeLa cells immunofluorescence native substrates. A quantitative analysis dynamics,...
20-40% of lung cancer patients develop bone metastasis (BM) with significantly decreased overall survival. Currently, BM is mainly diagnosed by computerized tomography (CT) scan or magnetic resonance imaging (MRI) when symptom develops. Novel biomarkers higher prediction value are needed. Plasma-derived exosomal microRNAs had been isolated and sequenced total 30 non-small cell (NSCLC) including 16 14 without metastasis. Hierarchical clustering based on the miRNA profile can clearly separate...
Abstract Background One of the major challenges in managing invasive breast cancer (BC) is lack reliable biomarkers to track response. Circulating tumor DNA (ctDNA) from liquid biopsy, as a candidate biomarker, provides valuable assessment BC patients. In this retrospective study, we evaluated utility ctDNA reflect efficacy treatment and monitor resistance mechanisms. Methods Targeted next‐generation sequencing (NGS) 416 cancer‐relevant genes was performed on 41 plasma biopsy samples 19...
Introduction: Platelet glycoprotein (GP) Ibα is a key receptor for thrombosis. Under high shear conditions, GPIbα-VWF interactions are required initiating platelet adhesion and vessel occlusion. GPIbα also an important checkpoint thrombo-inflammation in acute ischemic stroke. It has been considered as desirable target against stroke decades, but no anti-GPIbα drug successfully developed. Methods: CA1001 was humanized from our unique mAb crossing different species, manufactured under GMP-like...
3044 Background: Stereotactic ablative radiotherapy (SABR) is the preferred curative treatment for inoperable patients with stage I/IIA non–small-cell lung cancer (NSCLC). In cases where tumor inaccessible or biopsy carries a high risk of complications, SABR offered even in absence tissue diagnosis, based on likelihood malignancy as calculated by validated predictive models. these situations, blood liquid detecting circulating DNA (ctDNA) can serve an aide to confirm and allow molecular...
Faithful segregation of mitotic chromosomes requires bi-orientation sister chromatids, which relies on the sensing correct attachments between spindle microtubules and kinetochores. Although mechanisms underlying PLK1 activation have been extensively studied, regulatory that couple activity to accurate chromosome are not well understood. In particular, is implicated in stabilizing kinetochore-microtubule attachments, but how kinetochore regulated avoid hyperstabilized...
The effect of chronic 5 alpha-pregnane-3 alpha-ol-20-one (5 alpha 3 alpha; neurosteroid) treatment was investigated on the gamma-aminobutyric acid (GABA), alpha, and ligands that bind to benzodiazepine (BZ) site GABA-induced [36Cl-]influx in intact cultured mammalian cortical neurons. Chronic (1 microM; days) decreased efficacy GABA, because its Emax (maximal response) value decreased, whereas EC50 (potency) not altered. also BZ agonists like diazepam potentiate [36Cl-] influx, -Emax...
SUMMARY CD4+ T lymphocytes play an important role in the pathogenesis of systemic lupus erythematosus (SLE). To characterize clonal expansion cells murine models, we analysed cell clonality various organs young and nephritic MRL/lpr NZB/W F1 mice using reverse transcription–polymerase chain reaction (RT-PCR) subsequent single-strand conformation polymorphism (SSCP) analysis. We demonstrated that some identical clonotypes expanded accumulated different (the bilateral kidneys, brain, lung...
Circulating cell-free DNA (cfDNA) level has been demonstrated to be associated with efficacy in first generation EGFR TKIs non-small cell lung cancer (NSCLC). However, the role of dynamic cfDNA analysis using next-generation sequencing (NGS) patients subsequent third-generation remains unclear.From 2016 2019, 81 NSCLC T790M mutation either tissue or plasma who received treatment were enrolled. CfDNA sequenced by NGS a 425-gene panel. The association clinical characteristics, pretreatment,...
With the incorporation of more renewable energy sources, distribution networks are shifting from passive to active. The interconnection transmission and will increase tidal currents become bidirectional, affecting stable operation networks. This paper proposes a multi-timescale risk dispatch study for that have high proportion distributed access meet rising demand coupling between two types First, day-ahead scheduling model takes into account various operational risks is developed with goal...
Immunotherapy is currently approved for CRC whose tumors have high MSI-H. To find additional biomarkers immunotherapy in CRC, targeted sequencing was performed on tumor tissues from a discovery cohort of 161 patients. Validation cohorts the cBioPortal were also used survival and cell infiltration analyses. The FAT1-mutated group often co-occurred with MSI events displayed higher mutational burden compared to FAT1 wild-type CRC. Overall patients mutations than wild type FAT1. altered PI3K-AKT...
Abstract Objectives Pancreatic cancer (PC) is one of the most lethal malignancies with an increasing death rate over years. We performed targeted sequencing and survival analyses on 90 Chinese pancreatic patients, hoping to identify genomic biomarkers associated clinical outcomes therapeutic options. Method Genomic DNA was extracted from formalin‐fixed paraffin‐embedded (FFPE) tissue specimens patients sequenced. The associations clinicopathological factors were analyzed. Result High...
Esophageal squamous cell carcinoma (ESCC) is the major type of EC in China. Chemoradiotherapy a standard definitive treatment for early-stage and significantly improves local control overall survival late-stage patients. However, chemoradiotherapy resistance, which limits therapeutic efficacy treatment-induced toxicity, still leading problem break. To optimize selection ESCC patients chemoradiotherapy, we retrospectively analyzed clinical features genome landscape Chinese cohort 58 TP53 was...